ABSTRACT Indole and thiazole derivatives have garnered significant attention due to their potent antitumor activities. Encapsulation of such derivatives into polymeric nanoparticles offers several advantages, including improved molecular stability and targeted delivery to tumor sites, thereby enhancing their antineoplastic potential.
José Cleberson Santos Soares +4 more
wiley +1 more source
Cellular Delivery of Functional AntimiR Conjugated to Bio-Produced Gold Nanoparticles. [PDF]
Pourali P, Benson V.
europepmc +1 more source
Pathogenic Gαo Mutants Drive Dominant GPCR Coupling in GNAO1 Encephalopathies
Mutations in GNAO1, the gene encoding Gαo, are associated with a wide range of neurodevelopmental disorders. In this study, we show that Gαo variants linked to the most severe patient phenotypes fail to disengage from activated Gi/o‐coupled GPCRs, thereby blocking GRK‐mediated receptor phosphorylation and internalization.
Yonika A. Larasati +4 more
wiley +1 more source
Cargo-selective regulation of clathrin-mediated endocytosis by AMP-activated protein kinase. [PDF]
Orofiamma LA +14 more
europepmc +1 more source
Bovine coronavirus enters HRT-18 cells via membrane fusion and clathrin-mediated endocytosis in a low pH-, dynamin-, cholesterol-, microtubule-, Rab7-, and Rab11-dependent manner. [PDF]
Chen C +6 more
europepmc +1 more source
Molecular Physiology of the Neuronal Synapse. [PDF]
Ramírez-Expósito MJ +2 more
europepmc +1 more source
Selective Endocytosis-Mediated Omicron S1-RBD Internalization Revealed by Reconstitution of ACE2-S1-RBD Interaction on Micropatterned Membrane Substrates. [PDF]
Philip AM +4 more
europepmc +1 more source
Focal adhesion assembly and cell migration require myoferlin in PDAC cell lines. [PDF]
Gullo C +11 more
europepmc +1 more source
Super-Resolution Microscopy Reveals Alterations in Clathrin Structure in Human Cancer Tissue. [PDF]
Greig A +5 more
europepmc +1 more source

