Results 291 to 300 of about 134,599 (345)

A Hypoxia‐Responsive Near‐Infrared Phosphorescence Nanoprobe for High‐Sensitive Detection of Tumor Cells and Imaging of Colorectal Cancer In Situ

open access: yesAggregate, Volume 7, Issue 1, January 2026.
We have successfully developed a hypoxia‐responsive near‐infrared phosphorescent probe, Ir‐PEG. This nanoprobe demonstrates high sensitivity, water solubility, and deep‐tissue penetration. It remains specifically activatable even in the hypoxic intestinal environment, facilitating high‐contrast imaging of orthotopic colon cancer.
Jian Chen   +5 more
wiley   +1 more source

Virus infection and vesicle trafficking. [PDF]

open access: yesFront Immunol
Cao GX   +5 more
europepmc   +1 more source

Nanobiotechnology‐Based Approaches for Targeted Glioma Therapy

open access: yesAdvanced NanoBiomed Research, Volume 6, Issue 1, January 2026.
Nanoparticle systems cross the blood–brain barrier to deliver drugs precisely to glioma cells. Lipid, polymeric, and magnetic carriers enable controlled release, tumor targeting, and microenvironment modulation. These nanoplatforms enhance chemotherapy, radiotherapy, and immunotherapy, improving therapeutic efficacy while reducing systemic toxicity ...
Jinwei Li   +11 more
wiley   +1 more source

Visualization of lysosomal membrane proteins by cryo electron tomography. [PDF]

open access: yesNat Commun
McVeigh BM   +7 more
europepmc   +1 more source

New Quinoline Kinase Inhibitors With Good Selectivity for NAK Kinases and Anti‐Tumor Activity Against Ewing Sarcoma

open access: yesArchiv der Pharmazie, Volume 359, Issue 1, January 2026.
Focusing on the discovery of new therapeutics for childhood cancer, novel quinoline derivatives were synthesized and demonstrated activity against Ewing sarcoma. A target search was performed against a panel of kinases, and the compounds showed selectivity for the NAK family, mainly GAK, which was confirmed by enzyme kinetic assays.
Caroline de Bem Gentz   +17 more
wiley   +1 more source

Glutamate Receptors and Synaptic Plasticity in Health and Disease: A Personal Journey

open access: yesHippocampus, Volume 36, Issue 1, January 2026.
ABSTRACT I describe my progress in understanding synaptic plasticity in the hippocampus. Over the decades my lab has focused on the roles of glutamate receptors (AMPARs, NMDARs, mGluRs and KARs) and associated signaling molecules in LTP and LTD. Most of our studies have been conducted in area CA1 (Schaffer collateral—commissural pathway) with some ...
Graham L. Collingridge
wiley   +1 more source

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