Results 321 to 330 of about 126,267 (387)

Macrophage Efferocytosis as a Therapeutic Strategy in Intervertebral Disc Degeneration

Cell Proliferation, EarlyView.
Macrophages, integral to degenerated intervertebral discs, play a critical role in disc degeneration. By performing efferocytosis, they clear apoptotic cells. This article explores the process of efferocytosis, its molecular mechanisms, potential therapeutic implications for intervertebral disc degeneration and future strategies for targeted treatments.
Shijie Chen, Haijun Zhang, Zhaoheng Wang, Daxue Zhu, Yanhu Li, Yizhi Zhang, Dongxin Wang, Shuwei Chen, Huan Liu, Xuewen Kang   +9 more
wiley   +1 more source

Potential mechanisms of epigenetic regulation in diabetic retinopathy from the perspectives of multi-omics. [PDF]

Diabetol Metab Syndr
Luo X, Xue D.
europepmc   +1 more source

Extracellular vesicles in multiple myeloma: pathogenesis and therapeutic application

The FEBS Journal, EarlyView.
Multiple myeloma is characterised by the clonal proliferation of plasma cells in the bone marrow. Extracellular vesicles (EVs) are a key component of cell‐to‐cell communication within the bone marrow microenvironment, promoting tumour growth, bone remodelling, immune modulation, angiogenesis and therapeutic resistance.
Chloe Wylie, Rebecca Rowan, Dessi Malinova, Lisa Crawford   +3 more
wiley   +1 more source

Revisiting Pathogen Exploitation of Clathrin-Independent Endocytosis: Mechanisms and Implications. [PDF]

Cells
Goldmann O, Medina E.
europepmc   +1 more source

Wnt signalosome assembly is governed by conformational flexibility of Axin and by the AP2 clathrin adaptor. [PDF]

Nat Commun
Gammons MV, Franco-Echevarría E, Li TM, Rutherford TJ, Renko M, Batters C, Bienz M.   +6 more
europepmc   +1 more source

Multi‐omics analysis reveals discordant proteome and transcriptome responses in larval guts of Frankliniella occidentalis infected with an orthotospovirus

Insect Molecular Biology, EarlyView.
Tomato spotted wilt virus modulated the abundance of gut proteins in larval thrips, most notably manifested as a predominant down‐regulation in first instar larvae. Gut‐expressed protein and cognate transcript abundance were moderately correlated across the tissue system; however, the virus effect varied widely at transcriptional and translational ...
Jinlong Han, Dorith Rotenberg
wiley   +1 more source

Harnessing 3D cell models and high-resolution imaging to unveil the mechanisms of nanoparticle-mediated drug delivery. [PDF]

Front Bioeng Biotechnol
Chalkley AS, Lopez MT, Mysior MM, Brink MC, Kelly S, Simpson JC.   +5 more
europepmc   +1 more source

A comparison of super‐resolution microscopy techniques for imaging tightly packed microcolonies of an obligate intracellular bacterium

Journal of Microscopy, EarlyView.
Abstract Conventional optical microscopy imaging of obligate intracellular bacteria is hampered by the small size of bacterial cells, tight clustering exhibited by some bacterial species and challenges relating to labelling such as background from host cells, a lack of validated reagents, and a lack of tools for genetic manipulation.
Alison J. North, Ved P. Sharma, Christina Pyrgaki, John Lim S.Y., Sharanjeet Atwal, Kittirat Saharat, Graham D. Wright, Jeanne Salje   +7 more
wiley   +1 more source

Mannose-modified hemocyanin enhances pathogen endocytosis by crustacean hemocytes. [PDF]

J Biol Chem
Li J, Aweya JJ, Zhao M, Zhao Y, Lin Z, Chen X, Zheng Z, Li P, Yao D, Zhang Y.   +9 more
europepmc   +1 more source

Anatomy of a bioengineered human pigmented skin equivalent to provide fundamental insights into skin tone melanin dynamics

Journal of Anatomy, EarlyView.
Human pigmented skin equivalents can be created in vitro to resemble alternative skin tones. Such models can be used to study skin pigmentation processes, structural changes and defined patterns among different skin tones, which correlate with the diversity of pigmentation in native skin.
Paola De Los Santos Gomez, Ranjit Rai, Pamela Ritchie, Lucy Smith, Amy Simpson, Kirsty Goncalves, Stefan Przyborski   +6 more
wiley   +1 more source