Results 41 to 50 of about 958,954 (239)
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
Clean Ocean Advocate, March 2008
, 2008 The monthly Clean Ocean Advocate newsletter informs citizens about critical ocean pollution issues, important meeting dates, proposed legislation, special events, and other notes of interest.
core +1 more source
FEBS Letters, EarlyView.Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley +1 more source
CyTA - Journal of FoodUltrasound technology has gained increasing attention as a green, nonthermal approach for poultry meat processing; however, its industrial applicability remains limited by variability in reported outcomes and challenges in process standardization.
Fatma Al +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Пищевые системыGluten-free breads typically exhibit rapid firming and limited natural color diversity, which issues are usually addressed through multiple additives. This study evaluated the properties of adding fresh elderberry (Sambucus nigra) and spinach (Spinacia ...
R. Siminiuc, D. Țurcanu
doaj +1 more source
Clean label fresh sausage: characteristics throughout its shelf life [PDF]
Scientia AgricolaConsumers are increasingly demanding meat products that are natural and synthetic additive-free. This study aimed to develop a fresh pork sausage without synthetic additives and to evaluate the effects of this formulation on its physicochemical ...
Paula Regina Rabelo Sbardelotto +4 more
doaj +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Clean Ocean Advocate, October 2008
, 2008 The monthly Clean Ocean Advocate newsletter informs citizens about critical ocean pollution issues, important meeting dates, proposed legislation, special events, and other notes of interest.
core +2 more sources
Silent Killer: A Stealthy, Clean-Label, Black-Box Backdoor Attack
, 2023 Backdoor poisoning attacks pose a well-known risk to neural networks. However, most studies have focused on lenient threat models. We introduce Silent Killer, a novel attack that operates in clean-label, black-box settings, uses a stealthy poison and ...
Lederer, Tzvi +2 more
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