Results 91 to 100 of about 14,551 (299)

Study design requirements for RNA sequencing-based breast cancer diagnostics [PDF]

, 2016
Sequencing-based molecular characterization of tumors provides information required for individualized cancer treatment. There are well-defined molecular subtypes of breast cancer that provide improved prognostication compared to ...
Grönberg, Henrik, Klevebring, Daniel, Mer, Arvind Singh, Rantalainen, Mattias   +3 more
core   +1 more source

Esthetic perception of clear aligner therapy attachments using eye-tracking technology

American Journal of Orthodontics and Dentofacial Orthopedics, 2020
The purpose of this research was to assess and compare esthetic perceptions of clear aligner therapy with attachments and esthetic brackets by measuring differences in eye fixations using eye-tracking technology.The sample involved 250 adult subjects.
Jessica Kimberly Thai, Eustaquio Araujo, Julie McCray, Patricia Pigato Schneider, Ki Beom Kim   +4 more
openaire   +3 more sources

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

The Effect of Initial Orthodontic Therapy with Clear Aligners and Fixed Appliances on Microbial Profiles and Clinical Parameters

Journal of the California Dental Association
Background Orthodontic appliances hinder proper oral hygiene, leading to plaque retention and biofilm formation which can cause dental diseases. This study investigates the initial impact of orthodontic treatment with fixed appliances versus clear ...
Megan Haug, Andrew Hopkins, Emily Duong, Kim-Sa Kelly, Julia Esfandi, Bhumika Shokeen, Tingxi Wu, Renate Lux   +7 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Nanopipettes as Monitoring Probes for the Single Living Cell: State of the Art and Future Directions in Molecular Biology. [PDF]

, 2018
Examining the behavior of a single cell within its natural environment is valuable for understanding both the biological processes that control the function of cells and how injury or disease lead to pathological change of their function.
Bulbul, Gonca, Chaves, Gepoliano, Olivier, Joseph, Ozel, Rifat Emrah, Pourmand, Nader   +4 more
core   +2 more sources

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Evaluation of Awareness and Perception of Clear Aligner Orthodontic Treatment Among Students of Hawler Medical University.

Erbil Dental Journal
Background and Objectives: The growing emphasis on appearance has led to an increased   interest in orthodontic treatment among adults, particularly those who are highly self-conscious about their looks.
Maryam Fouad Bilal, Ahmed Qesim Ali, Layard Khalil Ibrahim   +2 more
doaj  

Evaluation of Tooth Movement Accuracy with the F22 Aligner System: A Retrospective Study

Applied Sciences
Background: To investigate the accuracy of an F22 Aligner system, considering the amount of prescribed movement, tooth type, grip points, sex and age. Methods: Digital models of 120 patients (64 females and 56 males; mean age 35.2 years ± 7.4) affected ...
Palone Mario, Silvia Squeo de Villagomez, Pellitteri Federica, Francesca Cremonini, Renato Salvatore, Luca Lombardo   +5 more
doaj   +1 more source

Consanguinity and rare mutations outside of MCCC genes underlie nonspecific phenotypes of MCCD. [PDF]

, 2015
Purpose3-Methylcrotonyl-CoA carboxylase deficiency (MCCD) is an autosomal recessive disorder of leucine catabolism that has a highly variable clinical phenotype, ranging from acute metabolic acidosis to nonspecific symptoms such as developmental delay ...
Barshop, Bruce A, Baumgartner, Matthias R, Frazer, Kelly A, Hansen, John-Bjarne, Jepsen, Kristen, Shepard, Peter J, Smith, Erin N   +6 more
core   +1 more source