Results 91 to 100 of about 1,602,450 (278)
Effect of frequent hemodialysis on residual kidney function. [PDF]
, 2013 Frequent hemodialysis can alter volume status, blood pressure, and the concentration of osmotically active solutes, each of which might affect residual kidney function (RKF).
Chertow, Glenn M +11 more
core +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Measured and estimated glomerular filtration rate. Numerous methods of measurements (Part I)
Revista de Nefrología, Diálisis y Trasplante, 2017 The loss of half the renal mass does not necessarily imply half the Glomerular Filtration Rate (GFR), meaning that there is not an exact correlation between renal mass reduction and renal function loss.
Jaime Pérez Loredo +2 more
doaj
Use of Estimating Equations for Dosing Antimicrobials in Patients with Acute Kidney Injury Not Receiving Renal Replacement Therapy. [PDF]
, 2018 Acute kidney injury (AKI) can potentially lead to the accumulation of antimicrobial drugs with significant renal clearance. Drug dosing adjustments are commonly made using the Cockcroft-Gault estimate of creatinine clearance (CLcr). The Modified Jelliffe
Awdishu, Linda +5 more
core +2 more sources
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
SEED QUALITY PARAMETERS OF PURPLE HORSEMINT FOR ELABORATION OF STANDART
Овощи России, 2016 Purple horsemint (Monarda citriodora L.) is a perennial plant belonging to Lamiaceae family and being cultivated as aromatic and ornamental crop in many countries of Europe and America. Last years this plant actively gains popularity among gardeners.
L. V. Pavlov +4 more
doaj +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
, 2011 News from the San Jose State University Record Clearance ...
San Jose State University, Department of Justice Studies,
core +1 more source
In Vivo Renal Clearance, Biodistribution, Toxicity of Gold nanoclusters
, 2012 Gold nanoparticles have shown great prospective in cancer diagnosis and therapy, but they can not be metabolized and prefer to accumulate in liver and spleen due to their large size.
Fan, Fei-Yue +5 more
core +1 more source