Results 91 to 100 of about 1,545,869 (342)
Evolutionary interplay between viruses and R‐loops
FEBS Letters, EarlyView.Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi +4 more
wiley +1 more source
Modified face seal for positive film stiffness [PDF]
, 1981 The film stiffness of a face seal is improved without increasing the sealing and dam area by using an apparatus which includes a primary seal ring in the form of a nose piece. A spring forces a sealing surface on the seal ring into sealing contact with a
Etsion, I., Lipshitz, A.
core +1 more source
Disruption of SETD3‐mediated histidine‐73 methylation by the BWCFF‐associated β‐actin G74S mutation
FEBS Letters, EarlyView.The β‐actin G74S mutation causes altered interaction of actin with SETD3, reducing histidine‐73 methylation efficiency and forming two distinct actin variants. The variable ratio of these variants across cell types and developmental stages contributes to tissue‐specific phenotypical changes. This imbalance may impair actin dynamics and mechanosensitive
Anja Marquardt +8 more
wiley +1 more source
Phenotyping of CYP3A by Oral Midazolam in Healthy Mazandarani Volunteers (Iran)
Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, 2011 BACKGROUND AND OBJECTIVE: CYP3A is responsible for hepatic microsomal metabolism of more than 50% of drugs which are its specific substrate. Metabolic activity of this enzyme depends on several factors.
MR Shiran +7 more
doaj
Numerical Analysis of the Influence of Clearance on Stress State and Contact Pressure in Plain Bearings [PDF]
Robotica & Management, 2017 In the analysis of plain bearings by finite element method it is important to model as closely to real state the aspects that influence the stress and contact pressure: the loading mode, the properties of the materials, the lubrication system, the ...
Vasile Cojocaru +1 more
doaj
Translational and Clinical Pharmacology, 2018 Adding to the complexity of caring for critically ill patients is the fact that many of them have a creatinine clearance that exceeds 130 mL/min/1.73 m2. This phenomenon, termed augmented renal clearance (ARC), has only recently been widely recognized and its pathogenesis remains incompletely understood.
openaire +3 more sources
Effect of monosodium glutamate additive on the performance of dialysis membrane [PDF]
, 2007 A novel dialysis membrane with monosodium glutamate (MSG) as an additive has been fabricated and its performance evaluated in terms of urea clearance.
Ahmed, Iqbal +2 more
core
Circulating histones as clinical biomarkers in critically ill conditions
FEBS Letters, EarlyView.Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez +17 more
wiley +1 more source
FEBS Letters, EarlyView.This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao +7 more
wiley +1 more source
Single‐cell insights into the role of T cells in B‐cell malignancies
FEBS Letters, EarlyView.Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley +1 more source