Results 151 to 160 of about 316,097 (341)

Endocytic Control of Cell‐Autonomous and Non‐Cell‐Autonomous Functions of p53

Advanced Science, EarlyView.
NUMB Ex3‐containing isoforms localize to the plasma membrane, where they recruit p53 through SNX9 and direct it to multivesicular bodies and exosomes. Exported p53 is taken up by neighboring cells and activates nuclear programs, revealing an intercellular, exosome‐based pathway that might help establish a tumor‐suppressive microenvironment.
Roberta Cacciatore, Andrea Basile, Stefano Freddi, Irene Schiano Lomoriello, Carlo Ribelle Zucca, Giuseppe Ciossani, Luigi Scietti, Alessandro Cuomo, Simona Ronzoni, Simone Pelicci, Mario Faretta, Elena Zaccheroni, Giuliana Pelicci, Vittoria Matafora, Angela Bachi, Rosalind Helen Gunby, Salvatore Pece, Sara Sigismund, Letizia Lanzetti, Ivan Nicola Colaluca, Pier Paolo Di Fiore   +20 more
wiley   +1 more source

Cell-intrinsic mechanical regulation of plasma membrane accumulation at the cytokinetic furrow

Proceedings of the National Academy of Sciences of the United States of America
Significance The actomyosin-based machinery that drives cell division is widely studied, but how actomyosin impacts the plasma membrane during cytokinesis is poorly understood.
Roberto Alonso-Matilla, Alice R. Lam, Teemu P. Miettinen   +2 more
semanticscholar   +1 more source

AI‐Based D‐Amino Acid Substitution for Optimizing Antimicrobial Peptides to Treat Multidrug‐Resistant Bacterial Infection

Advanced Science, EarlyView.
This study constructed the first D‐amino acid antimicrobial peptide dataset and developed an AI model for efficient screening of substitution sites, with 80% of candidate peptides showing enhanced activity. The lead peptide dR2‐1 demonstrated potent antimicrobial activity in vitro and in vivo, high stability, and low toxicity.
Yinuo Zhao, Qingzhou Kong, Haifan Gong, Lixiang Li, Jialu Fu, Boyao Wan, Peizhu Wang, Xiaojuan Li, Yue Wang, Jinghui Zhang, Yanbo Yu, Xiaoyun Yang, Xiuli Zuo, Haina Wang, Yanqing Li   +14 more
wiley   +1 more source

Biphasic targeting and cleavage furrow ingression directed by the tail of a myosin II

Journal of Cell Biology, 2010
The tail of yeast myosin II is localized to the division site by two distinct molecular pathways and sufficient for promoting actomyosin ring assembly, furrow ingression, and guidance in ECM remodeling.
X. Fang, Jianying Luo, R. Nishihama, C. Wloka, C. Dravis, Mirko Travaglia, Masayuki Iwase, E. Vallen, E. Bi   +8 more
semanticscholar   +1 more source

Central spindle self-organization and cytokinesis in artificially activated sea urchin eggs [PDF]

, 2016
Author Posting. © Marine Biological Laboratory, 2016. This article is posted here by permission of Marine Biological Laboratory for personal use, not for redistribution.
Buckley, Mary W., Henson, John H., Shuster, Charles B., Simerly, Calvin R., Weeks, Richard M., Yeterian, Mesrob   +5 more
core  

Bloodstream form trypanosoma brucei depend upon multiple metacaspases associated with RAB11-positive endosomes [PDF]

, 2006
Trypanosoma brucei possesses five metacaspase genes. Of these, MCA2 and MCA3 are expressed only in the mammalian bloodstream form of the parasite, whereas MCA5 is expressed also in the insect procyclic form.
Ambit, Audrey, Appleton, Paul, Coombs, Graham H., Helms, Matthew J., Mottram, Jeremy C., Tetley, Laurence   +5 more
core   +1 more source

Efficient Preservation of Perishable Fruits by Erasable Metal‐Organic Frameworks

Advanced Science, EarlyView.
This study presents an erasable Pickering emulsion‐based coating stabilized by metal‐organic frameworks. This washable coating significantly extends fruit shelf life by scavenging ethylene and inhibiting foodborne pathogens, offering a sustainable solution for postharvest.
Liying Yang, Jia Kong, Haoran Bai, Xiaojie Wu, Douxin Xiao, Ming Du, Peng Yang, Alideertu Dong   +7 more
wiley   +1 more source

Alpha-actinin localization in the cleavage furrow during cytokinesis

Journal of Cell Biology, 1978
We used antibodies against alpha-actinin and myosin labeled directly with contrasting fluorochromes to localize these contractile proteins simultaneously in dividing chick embryo cells.
K. Fujiwara, Mary E. Porter, Mary E. Porter, Thomas D. Pollard, Thomas D. Pollard   +4 more
semanticscholar   +1 more source

Identification of a putative germ plasm in the amphipod Parhyale hawaiensis [PDF]

, 2014
Background: Specification of the germ line is an essential event during the embryonic development of sexually reproducing animals, as germ line cells are uniquely capable of giving rise to the next generation.
Extavour, Cassandra G, Gupta, Tripti
core   +1 more source

Disrupting Lipid Raft Microdomains to Block Polyploid Giant Cancer Cell Budding and Enhance Radiotherapy Response

Advanced Science, EarlyView.
Radiation induces polyploid giant cancer cells (PGCCs) that regenerate tumors through virus‐like budding. This process depends on a SNCG–FLOT2–CHMP4B signaling axis functioning in lipid raft microdomains. Disrupting these domains using statins or anti‐PCSK9 antibodies blocks PGCC budding, suppresses tumor repopulation, and enhances radiotherapy ...
Zheng Deng, Haoran Sun, Jin Cheng, Ruyi Zhao, Jianzhu Xie, Yanwei Song, Yucui Zhao, Chenwei Lin, Binjie Hu, Yanping Gong, Jun Lin, Sijia He, Yuntao Luo, Minghui Zhao, Yiwei Wang, Ming Jiao, Yuqin Yang, Jikun Li, Shujie Xia, Chuanyuan Li, Qian Huang   +20 more
wiley   +1 more source