Mitochondria localize to the cleavage furrow in mammalian cytokinesis. [PDF]
PLoS ONE, 2013 Mitochondria are dynamic organelles with multiple cellular functions, including ATP production, calcium buffering, and lipid biosynthesis. Several studies have shown that mitochondrial positioning is regulated by the cytoskeleton during cell division in ...
Elizabeth J Lawrence, Craig A Mandato
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Delivery of ceramide phosphoethanolamine lipids to the cleavage furrow through the endocytic pathway is essential for male meiotic cytokinesis. [PDF]
PLoS Biology, 2022 Cell division, wherein 1 cell divides into 2 daughter cells, is fundamental to all living organisms. Cytokinesis, the final step in cell division, begins with the formation of an actomyosin contractile ring, positioned midway between the segregated ...
Govind Kunduri +11 more
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Specific detection of fission yeast primary septum reveals septum and cleavage furrow ingression during early anaphase independent of mitosis completion. [PDF]
PLoS Genetics, 2018 It is widely accepted in eukaryotes that the cleavage furrow only initiates after mitosis completion. In fission yeast, cytokinesis requires the synthesis of a septum tightly coupled to cleavage furrow ingression.
Juan Carlos G Cortés +9 more
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IFT proteins spatially control the geometry of cleavage furrow ingression and lumen positioning [PDF]
Nature Communications, 2017 Cytokinesis relies on central spindle organization and provides a spatial landmark for lumen formation. Here, the authors show that intraflagellar transport proteins are required for the localization of the cytokinetic regulator Aurora B and subsequent ...
Nicolas Taulet +8 more
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A lipid regulator working at the cleavage furrow. [PDF]
Cell Cycle, 2016 Cytokinesis occurs during the last phase of cell division and distributes the cytoplasm of one parent cell into 2 daughter cells.
Eto K, Denda H, Funato K.
europepmc +6 more sources
Membrane compartmentalization of Ect2/Cyk4/Mklp1 and NuMA/dynein regulates cleavage furrow formation. [PDF]
J Cell Biol, 2022 Chromosome separation is coupled with cleavage furrow formation during anaphase. Sana, Rajeevan, et al. demonstrate that the mutually exclusive localization of NuMA and Ect2/Cyk4/Mklp1 ensures dynein/dynactin and RhoA at distinct membrane zones to ...
Sana S, Rajeevan A, Kotak S.
europepmc +4 more sources
CLIC4 is a cytokinetic cleavage furrow protein that regulates cortical cytoskeleton stability during cell division. [PDF]
J Cell Sci, 2020 During mitotic cell division, the actomyosin cytoskeleton undergoes several dynamic changes that play key roles in progression through mitosis. Although the regulators of cytokinetic ring formation and contraction are well established, proteins that ...
Peterman E, Valius M, Prekeris R.
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Role of the Hof1-Cyk3 interaction in cleavage-furrow ingression and primary-septum formation during yeast cytokinesis. [PDF]
Mol Biol Cell, 2018 In Saccharomyces cerevisiae, it is well established that Hof1, Cyk3, and Inn1 contribute to septum formation and cytokinesis. Because hof1∆ and cyk3∆ single mutants have relatively mild defects but hof1∆ cyk3∆ double mutants are nearly dead, it has been ...
Wang M +3 more
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Focal adhesions control cleavage furrow shape and spindle tilt during mitosis. [PDF]
Sci Rep, 2016 The geometry of the cleavage furrow during mitosis is often asymmetric in vivo and plays a critical role in stem cell differentiation and the relative positioning of daughter cells during development.
Taneja N +6 more
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Agent-based modeling: case study in cleavage furrow models. [PDF]
Mol Biol Cell, 2016 The number of studies in cell biology in which quantitative models accompany experiments has been growing steadily. Roughly, mathematical and computational techniques of these models can be classified as “differential equation based” (DE) or “agent based”
Mogilner A, Manhart A.
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