Positioning the cleavage furrow: All you need is Rho. [PDF]
J Cell Biol, 2016 RhoA controls cleavage furrow formation during cell division, but whether RhoA suffices to orchestrate spatiotemporal dynamics of furrow formation is unknown. In this issue, Wagner and Glotzer (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201603025)
Liu Z, Weiner OD.
europepmc +5 more sources
Genetic suppression of a phosphomimic myosin II identifies system-level factors that promote myosin II cleavage furrow accumulation. [PDF]
Mol Biol Cell, 2014 Genetic interaction analysis is used to identify new cytokinesis proteins involved in myosin II cleavage furrow accumulation and to demonstrate how different pathways collaborate to drive myosin II to the cleavage furrow.
Ren Y +4 more
europepmc +4 more sources
A spindle-independent cleavage furrow positioning pathway. [PDF]
Nature, 2010 The mitotic spindle determines the cleavage furrow site during metazoan cell division, but whether other mechanisms exist remains unknown. Here we identify a spindle-independent mechanism for cleavage furrow positioning in Drosophila neuroblasts. We show
Cabernard C, Prehoda KE, Doe CQ.
europepmc +7 more sources
Unilateral Cleavage Furrows in Multinucleate Cells [PDF]
Cells, 2020 Multinucleate cells can be produced in Dictyostelium by electric pulse-induced fusion. In these cells, unilateral cleavage furrows are formed at spaces between areas that are controlled by aster microtubules.
Julia Bindl +5 more
doaj +7 more sources
Orbit/CLASP is required for myosin accumulation at the cleavage furrow in Drosophila male meiosis. [PDF]
PLoS ONE, 2014 Peripheral microtubules (MTs) near the cell cortex are essential for the positioning and continuous constriction of the contractile ring (CR) in cytokinesis.
Daishi Kitazawa +5 more
doaj +3 more sources
PH Domain-Arf G Protein Interactions Localize the Arf-GEF Steppke for Cleavage Furrow Regulation in Drosophila. [PDF]
PLoS ONE, 2015 The recruitment of GDP/GTP exchange factors (GEFs) to specific subcellular sites dictates where they activate small G proteins for the regulation of various cellular processes.
Donghoon M Lee +4 more
doaj +3 more sources
Arv1 promotes cell division by recruiting IQGAP1 and myosin to the cleavage furrow. [PDF]
Cell Cycle, 2016 Sundvold H +5 more
europepmc +4 more sources
IFT proteins accumulate during cell division and localize to the cleavage furrow in Chlamydomonas. [PDF]
PLoS ONE, 2012 Intraflagellar transport (IFT) proteins are well established as conserved mediators of flagellum/cilium assembly and disassembly. However, data has begun to accumulate in support of IFT protein involvement in other processes elsewhere in the cell.
Christopher R Wood +5 more
doaj +3 more sources
Fission yeast TRP channel Pkd2p localizes to the cleavage furrow and regulates cell separation during cytokinesis. [PDF]
Mol Biol Cell, 2019 Force plays a central role in separating daughter cells during cytokinesis, the last stage of cell division. However, the mechanism of force sensing during cytokinesis remains unknown.
Morris Z +4 more
europepmc +2 more sources
Phospholipase C-related catalytically inactive protein regulates cytokinesis by protecting phosphatidylinositol 4,5-bisphosphate from metabolism in the cleavage furrow. [PDF]
Sci Rep, 2019 Cytokinesis is initiated by the formation and ingression of the cleavage furrow. Phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2] accumulation followed by RhoA translocation to the cleavage furrow are prerequisites for cytokinesis progression.
Asano S +7 more
europepmc +2 more sources