Results 1 to 10 of about 1,174,566 (116)

ABR Features in Ski-Slope Hearing Loss for Hearing Threshold Estimation: A Comparative Clinical Study of Click and CE-Chirp Stimuli [PDF]

Children
Background: Auditory brainstem responses (ABRs) are widely used for objective hearing threshold estimation in both adults and children. Click and CE-Chirp stimuli differ substantially in cochlear activation and neural synchrony, yet their relative ...
Davide Brotto, Giuseppe Impalà, Elisa Lovato, Elena Mazzaro, Marco Maculan, Elisabetta Zanoletti, Nicole Galoforo, Patrizia Trevisi   +7 more
doaj   +2 more sources

Site‐Specific Surface Modification via Chemoselective Click Reactions on Cyclobutene‐Functionalized Monolayers [PDF]

ChemistryOpen
We report the first example of self‐assembled monolayers (SAMs) incorporating a cyclobutene‐substituted alkanethiol on a gold surface and the efficient modification of these monolayers via inverse electron‐demand Diels–Alder (IEDDA) cycloadditions. Mixed
Boone W. Evans, Kenneth N. Hipp, William D. Lambert, Wantanee Sittiwong, Rebecca Y. Lai, Patrick H. Dussault   +5 more
doaj   +2 more sources

Appropriate controls for digital therapeutic clinical trials: A narrative review of control conditions in clinical trials of digital therapeutics (DTx) deploying psychosocial, cognitive, or behavioral content

Frontiers in Digital Health, 2022
Digital therapeutics (DTx) are software programs that treat a disease or condition. Increasingly, DTx are part of medical care, and in the US healthcare system they are regulated by the FDA as Software as a Medical Device (SaMD).
Jacqueline Lutz, Emanuela Offidani, Emanuela Offidani, Laura Taraboanta, Shaheen E. Lakhan, Shaheen E. Lakhan, Timothy R. Campellone   +6 more
doaj   +1 more source

Preparing Children for an Unpredictable World in the Middle of a Crisis: La Aldea's Approach

Journal on Education in Emergencies, 2023
No one was prepared when COVID-19 hit. While education systems all over the world turned to distance learning, countries like Colombia faced a significant challenge: only 75 percent of Colombian teachers had received training in online teaching, 64 ...
Ana María Restrepo-Sáenz, Emmanuel Neisa Chateauneuf   +1 more
doaj   +1 more source

Development of oxaalkyne and alkyne fatty acids as novel tracers to study fatty acid beta-oxidation pathways and intermediates

Journal of Lipid Research, 2022
Fatty acid beta-oxidation is a key process in mammalian lipid catabolism. Disturbance of this process results in severe clinical symptoms, including dysfunction of the liver, a major beta-oxidizing tissue.
Lars Kuerschner, Philipp Leyendecker, Kristina Klizaite, Maria Fiedler, Jennifer Saam, Christoph Thiele   +5 more
doaj   +1 more source

Tracing Lipid Metabolism by Alkyne Lipids and Mass Spectrometry: The State of the Art

Frontiers in Molecular Biosciences, 2022
Lipid tracing studies are a key method to gain a better understanding of the complex metabolic network lipids are involved in. In recent years, alkyne lipid tracers and mass spectrometry have been developed as powerful tools for such studies.
Lars Kuerschner, Christoph Thiele
doaj   +1 more source

Biocompatible nanoreactors of catalase and nanozymes for anticancer therapeutics

Nano Select, 2021
Significant progress has laid the groundwork in understanding the fundamental role of catalase enzyme and catalase‐like nanozymes, notably with the emergence of nano‐bioreactors which are promoting nanomaterials‐based antitumor therapeutic strategies ...
Tanya Munjal, Saikat Dutta
doaj   +1 more source

Design, Synthesis and Biological Evaluation of Syn and Anti-like Double Warhead Quinolinones Bearing Dihydroxy Naphthalene Moiety as Epidermal Growth Factor Receptor Inhibitors with Potential Apoptotic Antiproliferative Action

Molecules, 2022
Our investigation includes the synthesis of new naphthalene-bis-triazole-bis-quinolin-2(1H)-ones 4a–e and 7a–e via Cu-catalyzed [3 + 2] cycloadditions of 4-azidoquinolin-2(1H)-ones 3a–e with 1,5-/or 1,8-bis(prop-2-yn-1-yloxy)naphthalene (2) or (6).
Essmat M. El-Sheref, Mohamed A. Ameen, Kamal M. El-Shaieb, Fathy F. Abdel-Latif, Asmaa I. Abdel-naser, Alan B. Brown, Stefan Bräse, Hazem M. Fathy, Iqrar Ahmad, Harun Patel, Hesham A. M. Gomaa, Bahaa G. M. Youssif, Asmaa H. Mohamed   +12 more
doaj   +1 more source

Three types of pulsed signal trains emitted by Indo-Pacific humpback dolphins (Sousa chinensis) in Beibu Gulf, South China Sea

Frontiers in Marine Science, 2022
Pulsed signal trains comprising clicks, buzzes, and burst-pulses play important roles in the life activities of odontocetes, but they have not been distinguished in Indo-Pacific humpback dolphins.
Xiao-yan Wang, Xiao-yan Wang, Ying Jiang, Ying Jiang, Ying Jiang, Zong-wei Liu, Zong-wei Liu, Zong-wei Liu, Chun-mei Yang, Chun-mei Yang, Chun-mei Yang, Bing-yao Chen, Lian-gang Lü, Lian-gang Lü, Lian-gang Lü   +14 more
doaj   +1 more source

Design and Implementation of Virtual Security Function Based on Multiple Enclaves

Future Internet, 2021
Network function virtualization (NFV) provides flexible and scalable network function for the emerging platform, such as the cloud computing, edge computing, and IoT platforms, while it faces more security challenges, such as tampering with network ...
Juan Wang, Yang Yu, Yi Li, Chengyang Fan, Shirong Hao   +4 more
doaj   +1 more source