Results 111 to 120 of about 3,191,477 (292)

A Novel Potent Nicotinamide Phosphoribosyltransferase Inhibitor Synthesized via Click Chemistry

, 2009
The inhibition of NAD synthesis or salvage pathways has been proposed as a novel target for antitumoral drugs. Two molecules with this mechanism of action are at present undergoing clinical trials. In searching for similar novel molecules, we exploited
G. COLOMBANO, A. CALDARELLI, CHINI, MARIA GIOVANNA, G. C. TRON, A. A. GENAZZANI, C. TRAVELLI, U. GALLI, P. L. CANONICO, BIFULCO, Giuseppe, G. SORBA, Bifulco G, GALLI, Ubaldina, COLOMBANO, GIAMPIERO, Galli U., CANONICO, Pier Luigi, Tron G. C., Giuseppe Bifulco (186812), Armando A. Genazzani (133336), Giampiero Colombano (2322544), Canonico P. L., Bifulco G., Gian Cesare Tron (1520005), Ubaldina Galli (1656103), GENAZZANI, Armando, Maria Giovanna Chini (186796), SORBA, Giovanni, Antonio Caldarelli (2180200), TRAVELLI, Cristina, Travelli C., Colombano G., TRON, Gian Cesare, Giovanni Sorba (1656118), Chini MG, Chini M. G., Pier Luigi Canonico (1656112), CALDARELLI, ANTONIO, Sorba G., Genazzani A. A., Caldarelli A., Cristina Travelli (1656115), Maria Giovanna Chini, Giampiero Colombano, Ubaldina Galli, Giovanni Sorba, Cristina Travelli, Gian Cesare Tron, Armando A. Genazzani, Antonio Caldarelli, Pier Luigi Canonico, Giuseppe Bifulco   +49 more
core   +1 more source

A Critical Review on the Evolution of Chitosan‐Based Injectable Hydrogels in Bone Regeneration

Advanced Materials Interfaces, EarlyView.
The graphical illustration depicts hydrogel formulation using chitosan and biocompatible cross‐linkers, major advantages, and incorporation of cells, osteoinductive factors, and therapeutic drugs. Following injection, pH‐responsive gelation enables controlled drug release, promotes cell recruitment and osteogenic differentiation, enhances extracellular
Shivani Santosh Sakhrani, Abu ul Hassan S. Rana, S. Sudheer Khan   +2 more
wiley   +1 more source

Programmable Variable‐Stiffness Multilayer Elastomer Composites With High‐Aspect‐Ratio Low‐Melting‐Point Alloy Inclusions

Advanced Materials Technologies, EarlyView.
High‐aspect‐ratio low‐melting‐point alloy inclusions are embedded within multilayer silicone laminates to create thermally programmable stiffness. Sequential activation of alloy‐rich layers produces four distinct mechanical states and reconfigures tendon‐driven actuator trajectories under the same load.
Palpolage Don Shehan Hiroshan Gunawardane, Gyan Edbert Zesiro, Hao Zhou, Gursel Alici, Mu Chiao   +4 more
wiley   +1 more source

Synthesis and properties of new fluorescent dyes and dye-labelled oligonucleotides

, 2012
Fluorescence is widely used in DNA sequencing and genetic analysis. Novel fluorescence techniques for studying nucleic acids and other biologically important molecules are constantly being developed.
Gerowska, Marta
core   +1 more source

Extrusion‐Based Bioprinting of Living Bioinks for Tissue and Organ Engineering

Advanced Materials Technologies, EarlyView.
Extrusion‐based bioprinting is presented as the most versatile route for fabricating living, heterogeneous tissues. Its ability to combine diverse bioinks, support matrices, and advanced printhead geometries transforms familiar constraints into powerful biofabrication opportunities.
Eric Silberman, Ester Sapir Baruch, Roni Cohen, Assaf Shapira, Tal Dvir   +4 more
wiley   +1 more source

Autonomous Navigation of Pollen‐Inspired Magnetic Microrobots for Biomedical Applications

Advanced Robotics Research, EarlyView.
A sunflower pollen‐inspired magnetic microrobot enables controlled rolling navigation in vessel‐like environments. Its open geometry reduces hydrodynamic drag, while vision‐based closed‐loop control, shortest‐path planning, and reinforcement learning support target‐reaching and maze navigation with microrobot‐scale accuracy, highlighting a route toward
Ali Anil Demircali, Abdurrahim Yilmaz, Meysam Keshavarz, Jinshi Zhao, Ara Darzi, Eric Yeatman, Burak Temelkuran   +6 more
wiley   +1 more source

cat-ELCCA: catalyzing drug discovery through click chemistry

, 2018
Click chemistry-based amplification assays provide enabling tools for chemical probe and drug discovery.
Amanda L. Garner
core   +1 more source

Cell‐Based Biohybrid Micro/Nanorobots for Biotherapy

Advanced Robotics Research, EarlyView.
This review systematically evaluates cell‐based biohybrid micro/nanorobots (CB‐BMRs), highlighting their cell selection criteria, fabrication strategies, and diverse actuation modes. Furthermore, it surveys the promising therapeutic applications of CB‐BMRs in targeted cancer, thrombosis, and inflammation treatments, while comprehensively discussing ...
Lin Wang, Chenlu Liu, Yu Zhao, Chuanhua Li, Xuyang Chen, Shixiao Ding, Lizhou Dai, Guokun Wang, Tianlong Li, Jiaxin Li, Xuejia Liu, Haocheng Wang   +11 more
wiley   +1 more source

Syntheses of Sulfo-Glycodendrimers Using Click Chemistry and Their Biological Evaluation

Molecules, 2012
A series of novel glycol-clusters containing sulfonated N-acetyl-D-glucosamine (GlcNAc) have been synthesized using click chemistry. Three dendrimers with aromatic dendrons were synthesized using chlorination, azidation and click chemistries.
Tomohiro Fukuda, Yoshiko Miura, Shunsuke Onogi   +2 more
doaj   +1 more source

Consensus Formation and Change are Enhanced by Neutrality

Advanced Science, EarlyView.
Neutral agents are shown to enhance both the formation and overturning of consensus in collective decision‐making. A general mathematical model and experiments with locusts and humans reveal that neutrality enables robust consensus via simple interactions and accelerates consensus change by reducing effective population size.
Andrei Sontag, Janina A. Hoffmann, Tim Rogers, Christian A. Yates   +3 more
wiley   +1 more source