Results 211 to 220 of about 319,759 (300)

Dynamic Self‐Clickable Decellularized Matrix Hydrogels for Regulating Vascularity and Enhancing Muscle Regeneration

Advanced Science, EarlyView.
Dynamic decellularized hydrogels are prepared using bovine decellularized small intestine submucosa (SIS) norbornene (dSIS‐NB). Bovine dSIS contained significant amounts of disulfide‐rich fibrillin‐I, enabling ‘self‐clickable’ thiol‐norbornene gelation and spatiotemporal tuning of hydrogel physicochemical properties.
Van Thuy Duong, Tuba Marjan, Ngoc Ha Luong, Taimoor H. Qazi, Chien‐Chi Lin   +4 more
wiley   +1 more source

Development of programmable RNA imaging with RNA-guided GFP via click chemistry. [PDF]

Nucleic Acids Res
Nakamura J, Shiraishi M, Yamamoto J, Suzuki K.   +3 more
europepmc   +1 more source

Rational Design of Broad‐Spectrum Anti‐Enteroviral Molecular Glues Targeting Enteroviral RNAi Suppressors

Advanced Science, EarlyView.
By leveraging this homodimerization mechanism, molecular glues were rationally designed to induce dysfunctional 3A dimerization, thereby restoring antiviral RNAi. The optimal molecular glue, VTP‐32, demonstrated potent and pan‐enterovirus (groups A, B, D) antiviral effects.
Yuan Fang, Xiong Xie, Huidi Fan, Botao Wu, An Wang, Wenhao Dai, Zezhong Liu, Jian Li, Huoyan Tong, Jianan Li, Yujie Ren, Jinlin Wang, Xi Zhou, Hong Liu   +13 more
wiley   +1 more source

Microfluidic Assembly of Poly(glutamic acid) Nanogels Through SPAAC Click Chemistry. [PDF]

Pharmaceutics
Mastella P, Luin S.
europepmc   +1 more source

Optimization of SWCNT‐FET Biosensors by Aptamer Engineering and Toehold‐Mediated Strand Displacement

Advanced Science, EarlyView.
Aptamer‐based single‐walled carbon nanotube (SWCNT) field‐effect transistor (FET) biosensors are developed for label‐free, real‐time biomarker detection. Truncated DNA aptamers enhance sensitivity through improved conformational switching. A toehold‐mediated strand displacement (TMSD) strategy optimizes functionalization and simplifies fabrication. The
Haosen Miao, Tingting Zheng, Houlin Yu, Gririraj Manoharan, Gustavo Sant'Anna, Nicholas Bedfrod, Jorge L. Chávez, Chang‐Seuk Lee, Matteo Palma   +8 more
wiley   +1 more source

Model-Assisted Process Optimization for Trivalent Ligand-siRNA Conjugation via CuAAC Click Chemistry. [PDF]

ACS Omega
Pan F, Yang S, Zhang R, Li J, Liu G, Chen J.   +5 more
europepmc   +1 more source

Injectable Hydrogel with Rapid Coagulation, Low Swelling, and High Burst Pressure Tolerance Properties for Long‐Term Management of Bleeding Wound

Advanced Science, EarlyView.
An injectable PACmC hydrogel with “rigid island‐flexible chain” architecture is developed, featuring low swelling (49.2% within 7 d), strong wet adhesion (46.5 kPa), and high burst pressure (701 mm Hg), which can achieve rapid hemostasis and long‐term sealing in rabbit and porcine models of hepatic and splenic hemorrhage.
Yang Ouyang, Wenfeng Qiu, Weiwen Liang, Xin Zhang, Weijie Liu, Zixin Chen, Yifei Li, Hui Wang, Youchen Tang, Min Li, Rongkang Huang, Zijian Chen, Binghua Ma   +12 more
wiley   +1 more source

Engineering Alloxazines by Boron Coordination and Click Chemistry toward Small-molecule Fluorescent Probes. [PDF]

Chemistry
Charpentier O, Mouhanna A, Nikolopoulos E, Guenet A, Gourlaouen C, Desage-El Murr M.   +5 more
europepmc   +1 more source

Paternal Caffeine Exposure Programs Offspring Stress Vulnerability via Sperm Dlk1‐Dio3 Imprinting‐Directed Remodeling of a Novel Neural Circuit

Advanced Science, EarlyView.
The study elucidates that paternal preconception stress can drive offspring hyperresponsivity of the stress system via hypomethylation of a specific DNA region in sperm. This key link is confirmed in a cohort of prospective fathers: the epigenetic alteration is associated with elevated stress hormone levels.
Mengxi Lu, Gaole Dai, Sen Zhu, Shuai Zhang, Tingting Wang, Yuan Meng, Fang Yang, Xiaoyi Han, Hui Wang, Hao Kou, Dan Xu   +10 more
wiley   +1 more source

Click Chemistry-Based Bioconjugation of Iron Oxide Nanoparticles. [PDF]

Small
Asad S, Ahl D, Suárez-López YDC, Erdélyi M, Phillipson M, Teleki A.   +5 more
europepmc   +1 more source