Results 261 to 270 of about 1,290,910 (349)

Self‐Assembled Dictamni Cortex Nanoparticles Ameliorate Psoriasis by Epigenetic Modulation of HSP90AB1 and Suppression of the Inflammatory Response

Advanced Science, EarlyView.
This study develops self‐assembled Dictamni Cortex (BXP)‐Fe(III) infinite coordination polymer nanoparticles (NB) to improve BXP's solubility and bioavailability for psoriasis. NB transdermally treats psoriasis by targeting the epigenetic regulator CTCF (CCCTC‐binding factor), suppressing HSP90AB1 (heat shock protein 90 alpha family class B member 1 ...
Zhengyi Zhang, Wenqian Du, Xiaojiang Zhang, Hongbo Cui, Baochen Cheng, Xiao Han, Ke He, Tingyi Yin, Xinyi Liu, Ningyi Xian, Ziyang Wang, Meng Liu, Dan Han, Jiankang Liu, Yan Zheng, Ya Wang   +15 more
wiley   +1 more source

Expanding the DNA Damaging Potential of Artificial Metallo-Nucleases with Click Chemistry

Kellett A, Gibney A, Sidarta M, KK S, Aning O, Arrué L, Figueiredo F, Mesdom P, Cariou K, Johansson P, Bhattacharya S, Thompson D, McKee V, Wenzel M, Gasser G, Westerlund F.   +15 more
europepmc   +1 more source

Design and Biosynthesis of Ornithine 8-Containing Semaglutide Variants with a Click Chemistry-Modifiable Position 26. [PDF]

ACS Synth Biol
Xu Y, Kuipers OP.
europepmc   +1 more source

RNA G‐Quadruplex RIBOTAC‐Mediated Targeted Degradation of lncRNA TERRA

Advanced Science, EarlyView.
This study introduces a selective RNA degradation strategy targeting long noncoding RNA (lncRNA) TERRA, upregulated in ALT (alternative lengthening of telomeres) cancer cells. Using ribonuclease‐targeting chimeras (RIBOTACs), RNase L is recruited to catalytically degrade TERRA, uncovering a novel approach to affect a disease associated lncRNA in ALT ...
Elias Khaskia, Dipak Dahatonde, Raphael I. Benhamou   +2 more
wiley   +1 more source

Efficient and Selective Biosynthesis of a Precursor-Directed FK506 Analogue: Paving the Way for Click Chemistry. [PDF]

J Nat Prod
Goranovič D, Jenko B, Ramšak B, Podgoršek Berke A, Bedrač L, Horvat J, Šala M, Makuc D, Carriche GM, Silva L, Lopez Krol A, Pšeničnik A, Durán Alonso MB, Avbelj M, Stavber S, Plavec J, Sparwasser T, Müller R, Kosec G, Fujs Š, Petković H.   +20 more
europepmc   +1 more source

Prolonged Cell Encapsulation and Gravity‐independent Filamented Light Biofabrication of Muscle Constructs

Advanced Science, EarlyView.
A gravity‐independent filamented light (G‐FLight) projection method is presented for rapid biofabrication of anisotropic tissues, demonstrated with muscle constructs as a target application. Specialized photocrosslinkable resins enable refrigeration or cryopreservation with encapsulated cells.
Michael Winkelbauer, Jakub Janiak, Johannes Windisch, Hao Liu, Maria Bulatova, Max Von Witzleben, Hugo Oliveira, Sophie Dani, Richard Frank Richter, Nicolas L’Heureux, Ori Bar‐Nur, Michael Gelinsky, Marcy Zenobi‐Wong, Parth Chansoria   +13 more
wiley   +1 more source

inCu-click: DNA-enhanced ligand enables live-cell, intracellular click chemistry reaction with copper catalyst. [PDF]

Nat Commun
Nian K, Liu Y, Qiu Y, Zhang Z, Brigandi L, Wanunu M, Rouhanifard SH.   +6 more
europepmc   +1 more source

Acidogenesis‐Propelled Coordination Transition in Light‐Triggered Fe‐Polyphenol Polymer for Reactive Oxygen Species‐Augmented Antitumor Therapy

Advanced Science, EarlyView.
A novel iron‐polyphenol‐photoacid coordination polymer (FeBPs) is designed to achieve red light‐triggered external acidification and internal coordination regulation, where this light‐controlled acidification induces coordination changes that enhance Fe active site exposure and provide H+ for beneficial Fe3+/Fe2+ conversion, thereby accelerating ROS ...
Ying Wan, Hui Liu, Lin Gao, Guanyu Tan, Kailin Li, Qiwei Tian, Shiping Yang, Lu An   +7 more
wiley   +1 more source

Targeting Fibrotic Scarring by Mechanoregulation of Il11ra1+/Itga11+ Fibroblast Patterning Promotes Axon Growth after Spinal Cord Injury

Advanced Science, EarlyView.
This study demonstrates that a hydrogel with mechanical properties matching the spinal cord directs fibroblast alignment, reshaping fibrotic scars into parallel matrices. A specific fibroblast subset mediates extracellular matrix remodeling through mechanotransduction, promoting axonal regeneration and neural reconnections, revealing potential ...
Longyou Xiao, Kaixi Shi, Wen Li, Jialin Liu, Pengfei Xie, Zijun Hu, Yu Dai, Haiyan Weng, Qiuju Yuan, Wutian Wu, Limin Rong, Liumin He   +11 more
wiley   +1 more source

Click/transclick reactions in combination with CRP: 'TAD's the spirit' [PDF]

, 2014
Billiet, Stijn, De Bruycker, Kevin, Driessen, Frank, Du Prez, Filip, Goossens, Hannelore, Van Speybroeck, Veronique, Winne, Johan   +6 more
core