Results 241 to 250 of about 3,191,477 (292)

Chemical Inhibition of Pyocyanin Biosynthesis Attenuates Virulence of Pseudomonas aeruginosa

Angewandte Chemie, EarlyView.
Anti‐virulence strategies disarm pathogens rather than killing them directly. A β‐lactone reduces pyocyanin production without affecting growth. Chemical proteomics identified PqsC as the primary target via binding to Cys129. Crystallography revealed the binding mode, and SAR yielded a chloroacetamide inhibitor with improved enzymatic potency and anti ...
Wei Ding, Sebastian R. Borgert, Wulf Blankenfeldt, Stephan A. Sieber   +3 more
wiley   +1 more source

Diels-Alder Click Chemistry as a Dynamic-Covalent Crosslinking Method in Spheroid-Encapsulating Hydrogels for Cartilage Engineering. [PDF]

Adv Healthc Mater
van de Looij SM, Vasilopoulou AG, Spauwen L, van den Dikkenberg A, Korpershoek JV, de Ruijter M, Malda J, van Ravensteijn BGP, Vermonden T.   +8 more
europepmc   +1 more source

Site‐Specific Protein Bioconjugation Through Cellular Incorporation of Noncanonical Amino Acids

Angewandte Chemie, EarlyView.
Genetic code expansion (GCE) enables site‐specific installation of noncanonical amino acids containing bioorthogonal conjugation handles, allowing precise, homogeneous protein modification. This review examines the principles of orthogonal translation, surveys the chemistries available for chemoselective labeling, and highlights emerging multi‐site ...
Rahul Sarkar, Manas Joshi, Abhishek Chatterjee   +2 more
wiley   +1 more source

Advancing Bioconjugated Quantum Dots with Click Chemistry and Artificial Intelligence to Image and Treat Glioblastoma. [PDF]

Cells
Kalaga P, Ray SK.
europepmc   +1 more source

Aktivierung von Metallkomplexen durch Ultraschallwellen für eine gezielte Krebstherapie

Angewandte Chemie, EarlyView.
Ultrasound enables non‐invasive activation of metal‐based therapeutics deep within tumors. Acoustic cavitation can drive sonodynamic reactive oxygen species generation or mechanochemical metal–ligand bond dissociation, enabling controlled release of bioactive payloads.
Félix Grosjean, Nicolás Montesdeoca, Gilles Berger, Johannes Karges   +3 more
wiley   +1 more source

Click-chemistry hydrogel for blood vessel organoids self-sustaining delivery to enhance flap survival. [PDF]

Mater Today Bio
Ju Y, Hsiung N, Yang P, Yang L, Pei J, Yang K, Zhao H, Zou P, Liu X, Qiao Z, Wang B, Wang X.   +11 more
europepmc   +1 more source

Ein Ruthenium(CAAC‐5)‐Olefin‐Metathese‐Katalysator für die Biokonjugation

Angewandte Chemie, EarlyView.
Die Instabilität von Rutheniumkatalysatoren in wässrigen Lösungen schränkt die Olefinmetathese in biologischen Medien ein. Es wird über einen Ru(CAAC‐5)‐Komplex berichtet, der unter biologisch relevanten Bedingungen aktiv bleibt und die Biokonjugation mit Proteinen, Peptiden und einem künstlichen Metalloenzym ermöglicht.
Damian Alexander Graf, Mikhail Boym, María Álvarez, Tsvetan Kardashliev, Thomas R. Ward   +4 more
wiley   +1 more source

Click Chemistry Mediated Immune Synapse Augmentation in Natural Killer Cell-Cancer Membrane Engagement and Facilitated Anticancer Efficacies of Natural Killer Cell Therapy. [PDF]

Biomater Res
Noh KM, Jangid AK, Kim E, Kim K.
europepmc   +1 more source

Functionalization and Metal Ion Encapsulation Within a Triaxial Supramolecular Weave

Angewandte Chemie, EarlyView.
The functionalization of a triaxially woven supramolecular weave was achieved. Pre‐assembly modification of the peptide‐perylene monoimide building block enabled facile and homogeneous introduction of acetyl, pivaloyl and thiophene moieties throughout the assembly without disrupting the woven structure.
Andreas Herdlitschka, Tatiana Da Silva‐Ferreira, Joseph F. Woods, Man Him Chak, Elisabeth Engelsberger, Bartosz Lewandowski, Helma Wennemers   +6 more
wiley   +1 more source

An Amino-Yne Click Chemistry Approach for Multi-Responsive Liquid Crystal Elastomer Actuators. [PDF]

Small
Bescós-Ramo S, Turriani M, Parmeggiani C, Piñol M, Oriol L, Martella D.   +5 more
europepmc   +1 more source