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Ultrafast Click Chemistry with Fluorosydnones
Angewandte Chemie International Edition, 2016AbstractWe report the synthesis and reactivity of 4‐fluorosydnones, a unique class of mesoionic dipoles displaying exquisite reactivity towards both copper‐catalyzed and strain‐promoted cycloaddition reactions with alkynes. Synthetic access to these new mesoionic compounds was granted by electrophilic fluorination of σ‐sydnone PdII precursors in the ...
Liu, Hui +13 more
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Click Bioconjugation: Modifying Proteins Using Click‐Like Chemistry
ChemBioChem, 2022AbstractBioconjugation deals with the chemical modification of proteins. The reactions used exploit either the intrinsic chemical reactivity of the biomolecule or introduce functionalities that can then be subsequently reacted without interfering with other functional groups of the biological entity.
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DNA Methyltransferase-Moderated Click Chemistry
Organic Letters, 2005[reaction: see text]. Biological methylation plays a vital role in regulatory mechanisms of gene transcription. Methylation of both promoter sequences within the genome, as well as protein substrates, has a profound impact upon gene transcription. Yet, few tools exist by which to identify sites of biological methylation in complex biological mixtures ...
Rachel L, Weller, Scott R, Rajski
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Hydrogel‐Based Macroscopic Click Chemistry
Angewandte Chemie, 2023AbstractThe click reaction has found good utility across various fields due to the characteristics of high efficiency, atom economy, simple and mild reaction conditions. Click chemistry is usually utilized for connecting components of microscopic level, while it is still unable for joining macroscopic building blocks.
Qingyun Li, Ziqing Hu, Xiaofan Ji
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Visible‐Light‐Induced Click Chemistry
Angewandte Chemie International Edition, 2015AbstractA rapid and catalyst‐free cycloaddition system for visible‐light‐induced click chemistry is reported. A readily accessible photoreactive 2H‐azirine moiety was designed to absorb light at wavelengths above 400 nm. Irradiation with low‐energy light sources thus enables efficient small‐molecule synthesis with a diverse range of multiple‐bond ...
Mueller, Jan O. +3 more
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Protein Iodination by Click Chemistry
ChemBioChem, 2009AbstractTwo steps to click iodine: We have developed a two‐step reaction for protein iodination using click chemistry. With this method, which is summarized in the scheme, covalent attachment of a stable iodine‐containing aromatic azide moiety to an alkyne‐containing protein was achieved.magnified ...
Dong, S., Moroder, L., Budisa, N.
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When Cyclodextrins Meet Click Chemistry
European Journal of Organic Chemistry, 2012AbstractCyclodextrins are important building blocks in organic chemistry. This review deals with the role of click chemistry in this family of cyclic oligosaccharides, focusing on the different areas of chemistry, including chromatography, biological applications, the elaboration of superstructures, and metal detection, that benefit from this reaction.
Faugeras, Pierre-Antoine +6 more
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Click chemistry in sphingolipid research
Chemistry and Physics of Lipids, 2018The term "click chemistry" was firstly coined by K. B. Sharpless in 2001 to refer to reactions that are high yielding, wide in scope, produce only easily removable byproducts and are stereospecific and simple to perform. Since then, this concept has been further developed and a large number of chemical reactions that fulfil totally or partially these ...
Eduardo Izquierdo, Antonio Delgado
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Click chemistry at the microscale
The Analyst, 2019This manuscript reviews recent developments in click chemistry in microscale systems.
Tingting Hong +3 more
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A Hitchhiker’s Guide to Click-Chemistry with Nucleic Acids
Chemical Reviews, 2021Nicolo Zuin Fantoni +2 more
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