Results 311 to 320 of about 328,516 (352)

Unnatural Triggers Converted From Tetrazine‐Attached Sialic Acid for Activation of Optoacoustic Imaging‐Guided Cancer Theranostics

Angewandte Chemie, EarlyView.
Tetrazine precursors (SiaTz) based on a nonO‐acetylated sialic acid scaffold are rationally designed and synthesized, which can be efficiently converted into unnatural tetrazine (Tz) triggers on cancer cell surfaces via metabolic glycoengineering. These Tz triggers activate theranostic agents for multispectral optoacoustic tomographic (MSOT) imaging ...
Yinglong Wu, Lihe Sun, Xiaodong Zhang, Wenbin Zhong, Xiaokai Chen, Shihuai Wang, Yun Chen, Dongdong Wang, Ting He, Hongzhong Chen, Jingjing Guo, Fang Zeng, Menghuan Li, Zhong Luo, Shuizhu Wu, Yanli Zhao   +15 more
wiley   +1 more source

Frontiers in DNA Synthesis: Click Chemistry [PDF]

, 2018

core   +1 more source

Gag HIV-1 Virus-like Particles and Extracellular Vesicles Functionalization with Spike Epitopes of SARS-CoV-2 Using a Copper-Free Click Chemistry Approach. [PDF]

Bioconjug Chem
García-Trujillo M, Lavado-García J, Boix-Besora A, Gòdia F, Cervera L.   +4 more
europepmc   +1 more source

Nanoparticle‐Mediated Targeted Protein Degradation: An Emerging Therapeutics Technology

Angewandte Chemie, EarlyView.
Targeted protein degradation (TPD) has emerged as a powerful therapeutic approach, with numerous candidates molecules now advancing into clinical development. Recent innovations have incorporated nanoparticles to facilitate and enhance these degradation processes, yielding synergistic effects.
Andrew G. Baker, Adrian Pui Ting Ho, Laura S. Itzhaki, Ljiljana Fruk   +3 more
wiley   +1 more source

SO₂F₂ mediated click chemistry enables modular disulfide formation in diverse reaction media. [PDF]

Nat Commun
Li H, Peng M, Li J, Wang L, Do H, Ni K, Wang M, Yuan Z, Zhao T, Zhang X, Zhang X, Hu Z, Ren F, An J.   +13 more
europepmc   +1 more source

Kontrolliertes Wachstum von Oligophenylen‐Strukturen auf Graphen und deren sekundäre Funktionalisierung

Angewandte Chemie, EarlyView.
Durch thermische Zersetzung verschiedener Peroxide auf BPO‐Basis mit unterschiedlichen Substituenten wurden dendrimere Oligophenylenstrukturen mit einer Dicke von bis zu 10 nm kontrolliert auf Graphen gezüchtet. Diese neu eingeführten Strukturen bieten aktive Stellen für eine weitere Funktionalisierung, da sie eine höhere Reaktivität als das Graphen ...
Christian E. Halbig, Felix Fels, Shenquan Wei, Robert Schusterbauer, Ievgen Donskyi, Markus R. Heinrich, Siegfried Eigler   +6 more
wiley   +1 more source

Small Extracellular Vesicles Engineered Using Click Chemistry to Express Chimeric Antigen Receptors Show Enhanced Efficacy in Acute Liver Failure. [PDF]

J Extracell Vesicles
Lu YT, Chen TY, Lin HH, Chen YW, Lin YX, Le DC, Huang YH, Wang AH, Lee CC, Ling TY.   +9 more
europepmc   +1 more source

closo‐Carboranylanaloga von β‐Arylethylaminen: Direkte Synthese aus Alkenen mittels EnT‐Katalyse

Angewandte Chemie, EarlyView.
Eine Strategie zur direkten Synthese von closo‐Carboranylanaloga medizinisch relevanter β‐Arylethylamine aus Alkenen wird vorgestellt. Die Reaktion basiert auf der erstmaligen Erzeugung von closo‐Carboranylradikalen mittels Energietransfer‐(EnT)‐Katalyse und ihren besonderen mechanistischen Merkmalen.
Fritz Paulus, Corinna Heusel, Marc Jaspers, Lilli M. Amrehn, Florian Schreiner, Debanjan Rana, Constantin G. Daniliuc, Michael Ryan Hansen, Frank Glorius   +8 more
wiley   +1 more source

Intramolecular chalcogen bonding activated SuFEx click chemistry for efficient organic-inorganic linking. [PDF]

Nat Commun
Wang M, Hou J, Do H, Wang C, Zhang X, Du Y, Dong Q, Wang L, Ni K, Ren F, An J.   +10 more
europepmc   +1 more source

Structural Basis for the Catalytic Mechanism of ATP‐Dependent Diazotase CmaA6

Angewandte Chemie, EarlyView.
Several diazotases have been reported in recent years, but the detailed catalytic mechanism is unclear. From X‐ray crystallography and Cryo‐EM analysis, we obtained the structure of a diazotase CmaA6, which synthesizes 3‐diazocoumaric acid. Kinetic analysis and computational analysis indicated that CmaA6 catalyzes diazotization via an unprecedented ...
Seiji Kawai, Masayuki Karasawa, Yoshitaka Moriwaki, Tohru Terada, Yohei Katsuyama, Yasuo Ohnishi   +5 more
wiley   +1 more source