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Analytical Chemistry, 2021
Alkaline phosphatase (ALP) has been used as a diagnostic index of clinical diseases since its expression level is closely related to many pathological processes. In this work, a highly sensitive electrochemiluminescence (ECL) method for the determination
Xiaocui Huang +5 more
semanticscholar +1 more source
Alkaline phosphatase (ALP) has been used as a diagnostic index of clinical diseases since its expression level is closely related to many pathological processes. In this work, a highly sensitive electrochemiluminescence (ECL) method for the determination
Xiaocui Huang +5 more
semanticscholar +1 more source
Click chemistry to functionalise peptidomimetics
Tetrahedron Letters, 2006Sharpless modified Huisgen's [2+3] cycloaddition of azide and acetylenic derivatives was employed as an efficient and simple method to conjugate azabicycloalkane amino acids, mimics of a homoSer-Pro dipeptide, with biologically relevant partners.
Leonardo Manzoni +5 more
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2014
This chapter describes the development of various methods used in the visualization of the glycosylation process in animals and in living cells, with particular focus on the development of reporter groups and molecular probes for use to monitor the posttranslational glycosylation event in normal and disease states in order to understand the process and
Chi-Hui Wong, Chung-Yi Wu
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This chapter describes the development of various methods used in the visualization of the glycosylation process in animals and in living cells, with particular focus on the development of reporter groups and molecular probes for use to monitor the posttranslational glycosylation event in normal and disease states in order to understand the process and
Chi-Hui Wong, Chung-Yi Wu
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Protein Iodination by Click Chemistry
ChemBioChem, 2009AbstractTwo steps to click iodine: We have developed a two‐step reaction for protein iodination using click chemistry. With this method, which is summarized in the scheme, covalent attachment of a stable iodine‐containing aromatic azide moiety to an alkyne‐containing protein was achieved.magnified ...
Shouliang Dong +2 more
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Click chemistry in sphingolipid research
Chemistry and Physics of Lipids, 2018The term "click chemistry" was firstly coined by K. B. Sharpless in 2001 to refer to reactions that are high yielding, wide in scope, produce only easily removable byproducts and are stereospecific and simple to perform. Since then, this concept has been further developed and a large number of chemical reactions that fulfil totally or partially these ...
Antonio Delgado +2 more
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Click chemistry-based biopolymeric hydrogels for regenerative medicine
Biomedical Materials, 2020Click chemistry is not a single specific reaction, but describes ways of generating products which emulate examples in nature. Click reactions occur in one pot, are not disturbed by water, generate minimal and inoffensive byproducts, and are ...
Ya Li +5 more
semanticscholar +1 more source
Injectable Click Chemistry-Based Bioadhesives for Accelerated Wound Closure
Acta Biomaterialia, 2020Tissue adhesives play a vital role in surgical processes as a substitute for sutures in wound closure. However, several existing tissue adhesives suffer from cell toxicity, weak tissue-adhesive strength, and high cost.
Shuxin Li +7 more
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Recent applications of click chemistry in drug discovery
Expert Opinion on Drug Discovery, 2019Introduction: Click chemistry has been exploited widely in the past to expedite lead discovery and optimization. Indeed, Copper-catalyzed azide-alkyne cycloaddition (CuAAC) click chemistry is a bioorthogonal reaction of widespread utility throughout ...
Xiangyi Jiang +6 more
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Transfer Printing of DNA by “Click” Chemistry
ChemBioChem, 2007AbstractThis paper describes a straightforward procedure to immobilize oligonucleotides on glass substrates in well‐defined micropatterns by microcontact printing with a dendrimer‐modified stamp. The oligonucleotides are efficiently immobilized by “click” chemistry induced by microcontact printing.
Rozkiewicz, DI +6 more
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Liquid Crystalline Elastomers Based on Click Chemistry.
ACS Applied Materials and Interfaces, 2022Yuzhan Li +6 more
semanticscholar +1 more source