Results 81 to 90 of about 1,290,910 (349)

Bioorthogonal Engineering of Cellular Microenvironments Using Isonitrile Ligations

Advanced Functional Materials, EarlyView.
Highly selective chemistries are required for fabrication and post‐cross–linking modification of cell‐encapsulating hydrogels used in tissue engineering applications. Isonitrile ligation reactions represent a promising class of bioorthogonal chemistries for engineering hydrogel‐based cellular microenvironments. Isonitrile‐based hydrogels are stable and
Ping Zhou, Lauren Brown, Christopher M. Madl   +2 more
wiley   +1 more source

Metabolic labelling of cholesteryl glucosides in Helicobacter pylori reveals how the uptake of human lipids enhances bacterial virulence. [PDF]

, 2016
Helicobacter pylori infects approximately half of the human population and is the main cause of various gastric diseases. This pathogen is auxotrophic for cholesterol, which it converts upon uptake to various cholesteryl α-glucoside derivatives ...
Chen, Yet-Ran, Chen, Yi-Chi, Gervay-Hague, Jacquelyn, Huang, Yu-Chen, Ingle, Arun B, Jan, Hau-Ming, Lin, Chun-Hung, Liu, Sheng-Wen, Mong, Kwok-Kong Tony, Shih, Yu-Yin, Tu, Zhijay, Wu, Ming-Shiang   +11 more
core   +1 more source

Advancing Electronic Application of Coordination Solids: Enhancing Electron Transport and Device Integration via Surface‐Mounted MOFs (SURMOFs)

Advanced Functional Materials, EarlyView.
The layer‐by‐layer (LbL) assembly of coordination solids, enabled by the surface‐mounted metal‐organic framework (SURMOF) platform, is on the cusp of generating the organic counterpart of the epitaxy of inorganics. The programmable and sequential SURMOF protocol, optimized by machine learning (ML), is suited for accessing high‐quality thin films of ...
Zhengtao Xu, Christof Wöll, Stefan Bräse   +2 more
wiley   +1 more source

Click-based synthesis and proteomic profiling of lipstatin analogues [PDF]

, 2010
Using click chemistry to enable both structural diversity and proteome profiling within a natural product derived library, two out of nineteen lipstatin analogues showed similar activity to Orlistat against fatty acid synthase (FAS), but with an improved
Adam, Brik, Browne, Carpita, Carvalho, Cheng, Evans, Garcia-Fandino, Guerciolini, Kai Liu, Kalesh, Kalesh, Keck, Knowles, Knowles, Kridel, Kridel, Little, Little, Ma, Markus R. Wenk, Martin J. Lear, Menendez, Menendez, Menendez, Mori, Morten Meldal, Mun H. Ngai, Pemble, Peng-Yu Yang, Pommier, Richardson, Shao Q. Yao, Sletten, Srinivasan, Srinivasan, Uttamchandani, Yang, Yuan Shen   +38 more
core   +1 more source

Fast Neutron Detector Based on Hybrid 2D Perovskite Thin Films

Advanced Functional Materials, EarlyView.
This work presents the direct detection of fast neutrons using flexible hybrid 2D perovskite (PEA2PbBr4) thin‐film detectors. Thanks to their high low‐Z elements content and good charge transport, these materials enable efficient neutron detection. The thin film configuration allowed the operation at low voltage, and offer scalability, flexibility, and
Ilaria Fratelli, Felix Pino, Laura Basiricò, Giulia Napolitano, Jessica Carolina Delgado, Sara Cepić, Andrea Ciavatti, Sandra Moretto, Gianluigi Maggioni, Marco Cinausero, Sara Maria Carturan, Beatrice Fraboni   +11 more
wiley   +1 more source

Metal Nanoclusters for Cancer Imaging and Treatment

Advanced Functional Materials, EarlyView.
This review aims to provide a comprehensive summary and discussion of the core–shell design capabilities of metal nanoclusters (NCs) at the atomic level for cancer imaging and treatment. It offers essential insights into the design principles of metal NCs while also encouraging the exploration of other nanomaterials and their potential theranostic ...
Haiguang Zhu, Ziping Wang, Qiaofeng Yao, Ping Zhang, Jianping Xie, Xun Yuan   +5 more
wiley   +1 more source

Triazole-Directed Pd-Catalyzed C(sp2)–H Oxygenation of Arenes and Alkenes [PDF]

, 2016
Selective Pd-catalyzed C(sp2)–H oxygenation of 4-substituted 1,2,3-triazoles is described. Unlike previous metal-catalyzed C–H functionalization events, which preferentially occur at the activated heterocyclic C–H bond, the regioselective oxygenation of ...
Aizpurua Iparraguirre, Jesús María, Correa Navarro, Arkaitz, Irastorza Epelde, Aitziber   +2 more
core   +2 more sources

Tunable Synthetic Hydrogel Modulates Hepatic Lineage Specification of Human Liver Organoid

Advanced Functional Materials, EarlyView.
In this study, a synthetic hydrogel is reported that supports the formation of hiPSC‐derived human liver organoids (HLOs). Hepatic lineage specification can be modulated via conjugation of RGD peptide to hydrogel: RGD‐conjugated hydrogels promote cholangiocyte differentiation, whereas RGD‐free hydrogels favor hepatocyte commitment of HLO cells.
Lei Wang, Lasse Riediger, Qi Rao, Xun Xu, Yan Nie, Yiduo Zhou, Junyao Zhang, Peng Tang, Weiwei Wang, Frank Tacke, Adrien Guillot, Ludovic Vallier, Irene Talon, Wenzhong Li, Yi‐An Yang, Rainer Haag, Nan Ma   +16 more
wiley   +1 more source

Poly(oxime-ester) Vitrimers with Catalyst-Free Bond Exchange. [PDF]

, 2019
Vitrimers are network polymers that undergo associative bond exchange reactions in the condensed phase above a threshold temperature, dictated by the exchangeable bonds comprising the vitrimer.
He, Changfei, Helms, Brett A, Russell, Thomas P, Shi, Shaowei, Wang, Dong   +4 more
core  

Engineering Topographical Cues to Enhance Neural Regeneration in Spinal Cord Injury: Overcoming Challenges and Advancing Therapies

Advanced Functional Materials, EarlyView.
Spinal cord injury (SCI) poses significant challenges for regeneration due to a series of secondary injury mechanisms. How to use biomaterial approach to target the failed regeneration after SCI remains a critical challenge. This review systematically evaluates current strategies to optimize biomaterial topographies for neurite outgrowth, axonal ...
Wei Xu, Fenghui Wang, Joshua Stein, Siqiao Wang, Pengfei Jiang, Letao Yang, Liming Cheng, Ki‐Bum Lee   +7 more
wiley   +1 more source