Results 161 to 170 of about 425,602 (258)

Genetic Encoding of Cyanopyridylalanine for In-Cell Protein Macrocyclization by the Nitrile-Aminothiol Click Reaction. [PDF]

Angew Chem Int Ed Engl, 2022
Abdelkader EH, Qianzhu H, George J, Frkic RL, Jackson CJ, Nitsche C, Otting G, Huber T.   +7 more
europepmc   +1 more source

Stiffness‐Activated Stellate Cells Drive Pancreatic Cancer Liver Colonization via GMFG‐TNS4 Signaling

Advanced Science, EarlyView.
Fibrotic liver stiffness activates hepatic stellate cells through Piezo1‐dependent calcium influx and ER stress, promoting EV‐associated GMFG release. Delivered GMFG engages TNS4 in pancreatic cancer cells, triggering FAK/AKT signaling, adhesion, and fatty acid synthesis.
Biwen Zhu, Jian Wan, Xue Zhang, Jiashuai Yan, Xi Chen, Xiaoqi Guan, Qianqian Ren, Tao Yang, Di Wu, Qingsong Guo, Yibing Guo, Yuhua Lu   +11 more
wiley   +1 more source

Lead free perovskite integrated metal organic framework as heterogeneous catalyst for efficient three component click reaction. [PDF]

Sci Rep
Kahkhaie LR, Oveisi AR, Sanchooli E, Daliran S, Khajeh M.   +4 more
europepmc   +1 more source

Amphiphilic Bowl-Shaped Janus Particles Prepared via Thiol-Ene Click Reaction for Effective Oil-Water Separation. [PDF]

Nanomaterials (Basel), 2023
Qi X, Du Y, Zhang Z, Zhang X.
europepmc   +1 more source

Revealing the Ion Regulation Effect of Zwitterionic All‐Solid‐State Electrolytes in Lithium Metal Batteries

Advanced Science, EarlyView.
This study investigates zwitterionic all‐solid‐state electrolytes, demonstrating strong carboxyl‐Li+ interaction that forms “ion‐enrichment pathway”‐like domains and manipulates Li+ deposition. Additionally, surface‐enriched zwitterions generate a dual‐layer SEI with an inner Li2O‐rich and outer LiF‐rich structure. Through ionic flux regulation and SEI
Wentao Xie, Yu Wu, Yierfan, Yuling Yang, Dongdong Gao, Liangbo Xu, Luoman Qin, Xingyu Lu, Yinjuan Chen, Changle Mu, Danyu Gu, Chunlei Wei, Yi He, Gang Cheng   +13 more
wiley   +1 more source

Preparation of Protein Lysates Using Biorthogonal Chemical Reporters for Click Reaction and in-Gel Fluorescence Analysis. [PDF]

Bio Protoc
Xu Y, Peng T.
europepmc   +1 more source

A Chemically Defined Four‐Component Self‐Adjuvanting Tn Vaccine Activating Mincle, FcγR, and CD206 for Enhanced Antitumor Immunity

Advanced Science, EarlyView.
A fully synthetic four‐component vaccine has been developed combining Tn antigen, vizantin (Mincle agonist), rhamnose (antibody recruitment), and mannose (CD206 targeting). By synergistically activating Mincle, FcγR, and CD206 pathways, it elicits strong IgG switching and cytotoxic T‐cells, significantly inhibiting tumors in mice.
Wenbo Ming, Renyu Zhang, Xiaohui Li, Guiqi Li, Yu Niu, Deying Yang, Xiang Luo, Jun Liao, Zhongqiu Liu, Guochao Liao   +9 more
wiley   +1 more source

Electrostatic catalysis of a click reaction in a microfluidic cell. [PDF]

Nat Commun
Sevim S, Sanchis-Gual R, Franco C, Aragonès AC, Darwish N, Kim D, Picca RA, Nelson BJ, Ruiz E, Pané S, Díez-Pérez I, Puigmartí-Luis J.   +11 more
europepmc   +1 more source

Biodegradable Acoustic Targeting for Ultrasound‐Supported Gene Therapy (BATUS) in Glioblastoma

Advanced Science, EarlyView.
ABSTRACT Glioblastoma (GBM) remains one of the most challenging brain malignancies due to the restrictive nature of the blood–brain barrier (BBB), which severely limits effective drug and gene delivery. To overcome this, we introduce Biodegradable Acoustic Targeting for Ultrasound‐Supported Gene Therapy (BATUS), a modular platform that enables safe ...
Gulsah Erel‐Akbaba, Jinyoung Park, Achal Duhoon, Cao Thuy Giang Nguyen, Nitu Bhaskar, Sumanta Kumar Karan, Hasan Akbaba, Parbeen Singh, Thi Bao Tram Tran, Yuhui Zhu, Zhiming Li, I'jaaz Muhammad, Xiaojun Zhang, Hoang Quan Truong, A. Daniel Davidar, Elizabeth Schmitzer, Vikas N. Vattipally, Angelica F. Lopez, Patrick Kramer, Victor M. Quiroz, Ben Bykov, Claire Hao, Amir Manbachi, Nicholas Theodore, Joshua C. Doloff, Thanh D. Nguyen   +25 more
wiley   +1 more source

Thiol-Specific Linkers for the Synthesis of Oligonucleotide Conjugates via Metal-Free Thiol-Ene Click Reaction. [PDF]

Bioconjug Chem
Malinowska AL, Huynh HL, Correa-Sánchez AF, Bose S.   +3 more
europepmc   +1 more source