Results 211 to 220 of about 436,100 (303)

Materials‐Guided Gene‐Ionizable Lipid Nanoparticles to Reverse Iron‐Associated Immune Resistance in Renal Cancer

Advanced Science, EarlyView.
ABSTRACT Iron overload is a common metabolic disturbance in cancer and contributes to poor outcomes in renal cell carcinoma (RCC), yet its effects on the tumour immune microenvironment remain unclear. Here we identify a previously unrecognized immunosuppressive axis in which iron overload downregulates the palmitoyltransferase ZDHHC12 in CD8+ T cells ...
Xin Jin, Yulong Hong, Chengliang Yin, Wanyang Guo, Yaxuan Wang, Ruijiang Zeng, Ruilin Liu, Zexian Ding, Xinlin Liu, Shangqing Ren, Qiyang Liang, Yaohui Wang, Xu Zhang, João Conde, Yuan Li, Xin Ma, Liangyou Gu   +16 more
wiley   +1 more source

Electrostatic catalysis of a click reaction in a microfluidic cell. [PDF]

Nat Commun
Sevim S, Sanchis-Gual R, Franco C, Aragonès AC, Darwish N, Kim D, Picca RA, Nelson BJ, Ruiz E, Pané S, Díez-Pérez I, Puigmartí-Luis J.   +11 more
europepmc   +1 more source

Manipulating Atomic Disorder and Mesoscale Architectures for High‐Efficiency Thermoelectric Modules

Advanced Science, EarlyView.
The in situ reaction of PbTiO3 precursor reacts in situ with the Bi0.5Sb1.5Te3 matrix, effectively enlarging the energy barrier for minority carrier excitation and suppressing bipolar diffusion, and predominantly scattering mid‐to‐low frequency phonons. Ultimately, a single thermoelectric module was fabricated to achieve a competitive efficiency of ∼7%
Jiwu Xin, Bo Wang, Chengyun Xu, Wang Li, Pengyu Zhang, Dongwang Yang, Yongke Wang, Jinfeng Dong, Lei Wei, Ting Zhang, Qinghui Jiang   +10 more
wiley   +1 more source

Thiol-Specific Linkers for the Synthesis of Oligonucleotide Conjugates via Metal-Free Thiol-Ene Click Reaction. [PDF]

Bioconjug Chem
Malinowska AL, Huynh HL, Correa-Sánchez AF, Bose S.   +3 more
europepmc   +1 more source

Nanocurvature‐Activated Dipolar Polarization in M–N4 Single‐Atom Sites for High‐Performance Electromagnetic Wave Absorption

Advanced Science, EarlyView.
Increasing nanocurvature effectively enriches the local electron density of the M–N4 motif, which facilitates electron transfer from the metal center to nitrogen atoms. This electronic behavior intensifies the localization and asymmetric distribution of charge, thereby significantly amplifying the dipole moment and polarizability.
Daohu Sheng, Siyao Cheng, Mengmeng Zhang, Jinglei Zhang, Xufei Zhu, Weijin Li, Bo Zhang, Aming Xie   +7 more
wiley   +1 more source

Click3D: Click reaction across deep tissues for whole-organ 3D fluorescence imaging. [PDF]

Sci Adv
Tamura I, Sakamoto DM, Yi B, Saito Y, Yamada N, Morimoto J, Takakusagi Y, Kuroda M, Kubota SI, Yatabe H, Kobayashi M, Harada H, Tainaka K, Sando S.   +13 more
europepmc   +1 more source

Enhanced Intracellular Stability and Translation Efficiency of mRNA Drugs by a 2‐arm mRNA Platform

Advanced Science, EarlyView.
We constructed a 2‐arm mRNA, characterized by a unique topology formed through the dimerization of two mRNA 3’ tails. The 2‐arm mRNA improves 3’ tail stability and resistance to nuclease degradation, resulting in an intracellular half‐life of up to 65 h. This method substantially enhances the translation capacity of mRNA drugs.
Xucong Teng, Jiahao Lin, Qiushuang Zhang, Xiangdong Zhang, Yicong Dai, Jinghong Li   +5 more
wiley   +1 more source

Time-Resolved Visualization of Cyanotoxin Synthesis via Labeling by the Click Reaction in the Bloom-Forming Cyanobacteria <i>Microcystis aeruginosa</i> and <i>Planktothrix agardhii</i>. [PDF]

Toxins (Basel)
Kurmayer R, Morón Asensio R.
europepmc   +1 more source

Dynamic Self‐Clickable Decellularized Matrix Hydrogels for Regulating Vascularity and Enhancing Muscle Regeneration

Advanced Science, EarlyView.
Dynamic decellularized hydrogels are prepared using bovine decellularized small intestine submucosa (SIS) norbornene (dSIS‐NB). Bovine dSIS contained significant amounts of disulfide‐rich fibrillin‐I, enabling ‘self‐clickable’ thiol‐norbornene gelation and spatiotemporal tuning of hydrogel physicochemical properties.
Van Thuy Duong, Tuba Marjan, Ngoc Ha Luong, Taimoor H. Qazi, Chien‐Chi Lin   +4 more
wiley   +1 more source

Protective Coatings Based on the Organosilicon Derivatives of Fatty Acids Obtained by the Thiol-Ene Click Reaction. [PDF]

Materials (Basel)
Szubert K, Liberski A.
europepmc   +1 more source