Results 191 to 200 of about 2,796,861 (304)

Isocyanate‐Modified Melatplatin(IV) Enhances Antitumor Efficacy via TCF4/COL6A3‐Mediated Extracellular Matrix Remodeling and cGAS‐STING Pathway Activation in Bladder Cancer

Advanced Science, EarlyView.
A series of melatonin‐conjugated platinum(IV) prodrugs was functionalized with isocyanate chains (compounds 5‒12). MP‐12C (compound 11) was identified as the lead candidate, with optimal potency and safety. MP‐12C exhibited greater efficacy than cisplatin by increasing intracellular uptake, reshaping the extracellular matrix, activating the cGAS‐STING ...
Linhui Wang, Xiaomeng Liu, Tao Zhu, Zirun Su, Ruiping Liu, Zhe Li, Kaixuan Du, Kaipeng Jia, Chong Fu, Yuda Lin, Zihan Xue, Zhe Zhang, Chong Shen, Yunkai Qie, Zhouliang Wu, Zhiheng Liu, Kangkang Liu, Jingyuan Xu, Hailong Hu   +18 more
wiley   +1 more source

Polymeric Micellar Nanocatalysts for CuAAC Click Reaction in Water. [PDF]

Langmuir
Sombat W, Padungros P, Hoven VP.
europepmc   +1 more source

On Click–Clip Reactions

CCS Chemistry
Jiantao Zhao, Huacheng Yu, Jiang-Fei Xu, Xi Zhang   +3 more
openaire   +1 more source

Plant Metabolites Screening Identifies 7‐epi‐10‐Deacetyltaxol Inhibiting Cell Division by Interfering With the Cell Cycle and Microtubule Organization

Advanced Science, EarlyView.
In this study, an efficient screening system is developed for plant metabolites to find a compound, 7‐epi‐10‐deacetyltaxol, inhibits tissue elongation. It suppresses plant growth through brassinosteroid and microtubule pathways. It is later applied to animal cells and human tumor organoids, resulting in similar cell division suppression. These findings
Yan‐Jie Zhang, Yu‐Xuan Bai, Geng G. Tian, Bin Zhang, Ding‐Yi Lu, Qing‐Ping Yao, Wen‐Hao Tian, Xiao‐Na Wei, Jing‐Ting Yang, Ze‐Yu Xiong, Yi Lu, Yu‐Tong Jiang, Chun‐Hui Cai, Yu‐Ming Lu, Xian‐Qing Jia, Li‐Li Jing, Bao‐Jun Yang, Ying‐Xin Qi, Xin‐Xin Han, Ji Wu, Wen‐Hui Lin   +20 more
wiley   +1 more source

Synthesis and Characterization of Natural Product-Based Steroid-Triazole Hybrids via Click Reaction and Evaluation of Their Anticancer and Antibacterial Activities. [PDF]

ACS Omega
Al-Awadhi FH, Mohamed AS, Habib OM, Al-Awadi NA.   +3 more
europepmc   +1 more source

"Click" Reaction-Mediated Silk Fibroin-Functionalized Thiol-Branched Graphene Oxide Quantum Dots for Smart Sensing of Tetracycline. [PDF]

ACS Omega, 2023
Goswami KJ, Sen Sarma N.
europepmc   +1 more source

A Gut‐Brain Axis Underlying Succinate‐Associated Compulsive‐Like Behavior

Advanced Science, EarlyView.
Gut‐derived succinate is associated with an excitatory‐inhibitory imbalance in dmPFC glutamatergic neurons, involving microglial SUCNR1 activation and vagal afferent signaling via upregulated gut 5‐HT4 receptors along the DVC‐CeA‐dmPFC circuit, changes that are linked to excessive compulsive‐like behavior.
Yi Li, Ying‐Dan Zhang, Wei Wang, Xin‐Yi Wu, Di Li, Xin Gong, Fei Tian, Meng‐Yu Dai, Jian Gao, Zi‐Feng Zheng, Zi‐Yang Bi, Dong‐Dong Shi, Zhen Wang   +12 more
wiley   +1 more source

Photopolymerization Using Thiol-Epoxy 'Click' Reaction: Anionic Curing through Photolatent Superbases. [PDF]

ACS Polym Au
Khan A.
europepmc   +1 more source

The thiol-sulfoxonium ylide photo-click reaction for bioconjugation. [PDF]

Chem Sci, 2023
Wan C, Hou Z, Yang D, Zhou Z, Xu H, Wang Y, Dai C, Liang M, Meng J, Chen J, Yin F, Wang R, Li Z.   +12 more
europepmc   +1 more source

Synthesis of Enantiopure Triazole-Modified Homoalanine Derivatives

Click reaction was applied to aminoacid derivatives with excellent ...
Streļņikova, Nataļja, Kumpiņš, Viktors, Kalējs, Udo, Otikovs, Mārtiņš, Turks, Māris   +4 more
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