Results 251 to 260 of about 2,673,237 (301)

Microglial TSPAN4‐Dependent Migrasomes Promote Pathological Retinal Neovascularization via Immune‐Vascular Crosstalk

Advanced Science, EarlyView.
Combined high‐glucose and hypoxic stress switches microglia into a TSPAN4‐dependent migrasome‐producing state. These migrasomes deliver pro‐angiogenic signals to endothelial cells, activating HIF‐1α/VEGF signaling, disrupting vascular junctions, and fueling pathological neovascularization. This work uncovers migrasome‐mediated immune‐vascular crosstalk
Jingyi Xu, Jingfan Wang, Pengfei Ge, Qinyuan Gu, Hongying Li, Yuanyuan Fan, Haiyue Xie, Yangyang Lu, Yifan Lin, Xinjing Wu, Chengkun Wang, Ping Xie, Zizhong Hu   +12 more
wiley   +1 more source

Plant Metabolites Screening Identifies 7‐epi‐10‐Deacetyltaxol Inhibiting Cell Division by Interfering With the Cell Cycle and Microtubule Organization

Advanced Science, EarlyView.
In this study, an efficient screening system is developed for plant metabolites to find a compound, 7‐epi‐10‐deacetyltaxol, inhibits tissue elongation. It suppresses plant growth through brassinosteroid and microtubule pathways. It is later applied to animal cells and human tumor organoids, resulting in similar cell division suppression. These findings
Yan‐Jie Zhang, Yu‐Xuan Bai, Geng G. Tian, Bin Zhang, Ding‐Yi Lu, Qing‐Ping Yao, Wen‐Hao Tian, Xiao‐Na Wei, Jing‐Ting Yang, Ze‐Yu Xiong, Yi Lu, Yu‐Tong Jiang, Chun‐Hui Cai, Yu‐Ming Lu, Xian‐Qing Jia, Li‐Li Jing, Bao‐Jun Yang, Ying‐Xin Qi, Xin‐Xin Han, Ji Wu, Wen‐Hui Lin   +20 more
wiley   +1 more source

Beyond Charge: Field‐Effect Transistors in Multimodal Biosensing Platforms for Biomolecular Interaction Studies

Advanced Electronic Materials, EarlyView.
This review summarizes the developments in field‐effect transistor (FET)‐based dual‐mode sensor platforms and what can be learned from them. It identifies charge as a crucial factor in biomolecular interactions at interfaces, outlines the challenges of hybrid systems, and highlights their benefits.
Roger Hasler, Ciril Reiner‐Rozman, Christoph Kleber, Jakub Dostalek, Wolfgang Knoll   +4 more
wiley   +1 more source

Synthesis of thermo-responsive polymer gels composed of star-shaped block copolymers by copper-catalyzed living radical polymerization and click reaction. [PDF]

Sci Technol Adv Mater
Gao G, Hara M, Seki T, Takeoka Y.
europepmc   +1 more source

Access to Artemisinin-Triazole Antimalarials via Organo-Click Reaction: High In Vitro/In Vivo Activity against Multi-Drug-Resistant Malaria Parasites. [PDF]

JACS Au
Herrmann L, Leidenberger M, Quadros HC, Grau BW, Hampel F, Friedrich O, Moreira DRM, Kappes B, Tsogoeva SB.   +8 more
europepmc   +1 more source

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A laccase-catalysed tyrosine click reaction

Organic & Biomolecular Chemistry, 2020
The tyrosine click reaction of peptides/proteins with the tyrosine modification reagent, N -methyl luminol, was catalysed by a laccase in the presence of molecular oxygen (O 2 ) at 37 °C.
Shinichi Sato, Keita Nakane, Hiroyuki Nakamura   +2 more
openaire   +2 more sources

Light‐Induced Click Reactions

Angewandte Chemie International Edition, 2013
AbstractSpatial and temporal control over chemical and biological processes, both in terms of “tuning” products and providing site‐specific control, is one of the most exciting and rapidly developing areas of modern science. For synthetic chemists, the challenge is to discover and develop selective and efficient reactions capable of generating useful ...
Mehmet Atilla, Tasdelen, Yusuf, Yagci
openaire   +2 more sources

A Photoinduced, Benzyne Click Reaction

Organic Letters, 2014
The [3 + 2] cycloaddition of azides and alkynes has proven invaluable across numerous scientific disciplines for imaging, cross-linking, and site-specific labeling among many other applications. We have developed a photoinitiated, benzyne-based [3 + 2] cycloaddition that is tolerant of a variety of functional groups as well as polar, protic solvents ...
Adam W, Gann, Jon W, Amoroso, Vincent J, Einck, Walter P, Rice, James J, Chambers, Nathan A, Schnarr   +5 more
openaire   +2 more sources

Click reactions with functional sphingolipids

Biological Chemistry, 2018
Abstract Sphingolipids and glycosphingolipids can regulate cell recognition and signalling. Ceramide and sphingosine-1-phosphate are major players in the sphingolipid pathways and are involved in the initiation and regulation of signalling, apoptosis, stress responses and infection.
Julian, Fink, Jürgen, Seibel
openaire   +2 more sources

Click Reactions with Nitroxides

Synthesis, 2009
Copper-catalyzed azide-alkyne 1,3-dipolar cycloadditions (CuAAC) with paramagnetic azide and alkyne building blocks are described. This method provides a route to the synthesis of complex spin-labeled molecules such as amino acids, carbohydrates, drug molecules and biradicals.
Kálmán Hideg, Tamás Kálai, Wayne Hubbell   +2 more
openaire   +1 more source