Results 251 to 260 of about 2,796,861 (304)

Histone Lactylation Drives WNK1 Expression to Promote Esophageal Squamous Cell Carcinoma Progression Through Histone H3 Ser10 Phosphorylation

Advanced Science, EarlyView.
In brief. Yan et al. demonstrated that the excess lactate produced by the enhanced glycolysis pathway in esophageal cancer can lactylate H3K23, H3K23la can be enriched in the WNK1 promoter region to promote WNK1 expression, thereby increasing the phosphorylation of the p‐H3 Ser10 site, and p‐H3S10 can be enriched in the AKT1 promoter region to promote ...
Mingyang Yan, Shaobo Fang, Yanming Song, Lei Zhang, Kexin Zhao, Zhenwei Wang, Yang Shao, Meng Liu, Xinyang Jia, Qinxin Guo, Mee‐Hyun Lee, Guoguo Jin, Zigang Dong   +12 more
wiley   +1 more source

Photoelectrocatalytic Diazidation of Olefins via Synergistic Dual Iron Species

Advanced Science, EarlyView.
We report a simple and general approach for 1,2‐diazidation of alkenes by a photoelectrochemical strategy using TMSN3 as an azide source. This transformation proceeds using earth‐abundant iron under mild reaction conditions. It displays broad functional group compatibility and accommodates diverse alkene types‐including unactivated, activated, electron‐
Zhi‐Peng Guan, Zhong‐Qi Yi, Ning Li, He‐Yi Li, Jun Yao, Hong‐Gui Huang, Zhi‐Bing Dong   +6 more
wiley   +1 more source

Phase‐Programmed Microneedles Enable Sequential Hydrogen and Quercetin Release for Scar‐Reduced Regeneration of Burn Wounds

Advanced Science, EarlyView.
A phase‐programmed microneedle patch, comprising a poly (lactic‐co‐glycolic acid) (PLGA) shell and a sulfobutylether‐β‐cyclodextrin (SBECD) core, is designed for sequential hydrogen and quercetin release for scar‐reduced regeneration of burn wounds. ABSTRACT Burn wounds complicated by bacterial infection and fibrotic scarring remain a major clinical ...
Yongnian Zeng, Zhigang Chu, Huiyuan Yang, Wen Zhang, Peng Jiang, Jiapeng Lei, Siyu Zhang, Qiongfang Ruan, Shuhua Liu, Wei Li   +9 more
wiley   +1 more source

DUSP26 Regulated by YY1 Lactylation Couples Osteogenesis and Angiogenesis by Dephosphorylating PMPCB at Y141 and Activating Mitophagy in BMSCs

Advanced Science, EarlyView.
p300‐associated YY1 lactylation promotes DUSP26 expression in BMSCs. By regulating PMPCB phosphorylation and PINK1 processing, DUSP26 supports mitophagy, osteogenic differentiation, and pro‐angiogenic factor secretion. BMSC‐derived exosomes carrying a RUNX2 promoter‐driven DUSP26 plasmid favor osteogenic‐lineage transgene expression, partially ...
Yunpeng Lv, Feng Wu, Xiongjie Liang, Chong Liu, Wenhui Guo, Kejian Zhang, Jiawen Niu, Wenjie Jiang, Hongjian Xu, Anlong Jiang, Yang Zheng, Enming Yu, Xintao Wang, Jinglong Yan, Jingjun Xia, Chengchao Song   +15 more
wiley   +1 more source

Disrupted Top‐Down Modulation as a Mechanism of Impaired Multisensory Processing in Autistic Children

Advanced Science, EarlyView.
In this work, we show that multisensory integration in autistic children is characterized by attenuated ERP responses and α‐band desynchronization, together with reduced theta‐band communication between parieto‐occipital and frontal regions. The intermediate neural profile observed in unaffected siblings raises the possibility that altered cortical ...
Theo Vanneau, John J. Foxe, Shlomit Beker, Sophie Molholm   +3 more
wiley   +1 more source

Synthesis of thermo-responsive polymer gels composed of star-shaped block copolymers by copper-catalyzed living radical polymerization and click reaction. [PDF]

Sci Technol Adv Mater
Gao G, Hara M, Seki T, Takeoka Y.
europepmc   +1 more source

Access to Artemisinin-Triazole Antimalarials via Organo-Click Reaction: High In Vitro/In Vivo Activity against Multi-Drug-Resistant Malaria Parasites. [PDF]

JACS Au
Herrmann L, Leidenberger M, Quadros HC, Grau BW, Hampel F, Friedrich O, Moreira DRM, Kappes B, Tsogoeva SB.   +8 more
europepmc   +1 more source

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Fluorogenic click reaction

Chem. Soc. Rev., 2010
Fluorogenic Cu(I)-catalyzed alkyne-azide cycloaddition (CuAAC) reactions have emerged as a powerful tool for bioconjugation, materials science, organic synthesis and drug discovery. This review highlights the design of the recent development of fluorogenic CuAAC reactions as well as their applications.
Céline, Le Droumaguet, Chao, Wang, Qian, Wang   +2 more
openaire   +2 more sources

A laccase-catalysed tyrosine click reaction

Organic & Biomolecular Chemistry, 2020
The tyrosine click reaction of peptides/proteins with the tyrosine modification reagent, N -methyl luminol, was catalysed by a laccase in the presence of molecular oxygen (O 2 ) at 37 °C.
Shinichi Sato, Keita Nakane, Hiroyuki Nakamura   +2 more
openaire   +2 more sources

Development of a Borane–(Meth)acrylate Photo-Click Reaction [PDF]

Angewandte Chemie - International Edition, 2021
The development of 3D printing fuels the need for new photoinitiating systems working under mild conditions and/or leading to polymers with new and/or enhanced properties.
Jan Blahut, Guido Pintacuda, Muriel Lansalot   +2 more
exaly   +2 more sources