Results 61 to 70 of about 2,411,722 (343)

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

How atmospheric humidity drives the outgoing longwave radiation–surface temperature relationship and inter-model spread

Environmental Research Letters, 2023
The Earth’s global radiation budget depends critically on the relationship between outgoing longwave radiation (OLR) and surface temperature ( $T_\mathrm{s}$ ).
Jing Feng, David Paynter, Chenggong Wang, Raymond Menzel   +3 more
doaj   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Multicentennial Variability Driven by Salinity Exchanges Between the Atlantic and the Arctic Ocean in a Coupled Climate Model

Journal of Advances in Modeling Earth Systems, 2021
The IPSL‐CM6‐LR atmosphere‐ocean coupled model exhibits a pronounced multicentennial variability of the Atlantic meridional overturning circulation (AMOC), driven by delayed freshwater accumulation and release in the Arctic.
Weimin Jiang, Guillaume Gastineau, Francis Codron   +2 more
doaj   +1 more source

Multivariate statistical modelling of future marine storms [PDF]

, 2017
Extreme events, such as wave-storms, need to be characterized for coastal infrastructure design purposes. Such description should contain information on both the univariate behaviour and the joint-dependence of storm-variables.
García León, Manuel, Gracia Garcia, Vicente, Lin Ye, Jue, Lionello, Piero, Ortego Martínez, María Isabel, Sánchez-Arcilla Conejo, Agustín   +5 more
core   +2 more sources

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Disaster risk management or adaptation to climate change; How to deal with climate issue in Colombia? Analysis from agenda setting and traveling model perspectives of the elaboration of climate policies. [PDF]

, 2019
The main purpose of this work is to understand, in an actor oriented perspective, the context in which climate policy are formulated in a country, Colombia.
Howland, Fanny, Le Coq, Jean-François
core  

Quantifying the impact of model inaccuracy in climate change impact assessment studies using an agro-hydrological model [PDF]

Numerical simulation models are frequently applied to assess the impact of climate change on hydrology and agriculture. A common hypothesis is that unavoidable model errors are reflected in the reference situation as well as in the climate change ...
Droogers, P., Immerzeel, W.W., Loon, A.F., van   +2 more
core   +1 more source

Predicting the Impact of Climate Change on Threatened Species in UK Waters [PDF]

, 2013
Global climate change is affecting the distribution of marine species and is thought to represent a threat to biodiversity. Previous studies project expansion of species range for some species and local extinction elsewhere under climate change.
Cheung, W, Dye, SR, Fernandes, JA, Frölicher, TL, Jones, MC, Pinnegar, JK   +5 more
core   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source