Results 71 to 80 of about 84,817 (240)

Climbing Your Way To Wellness: A Review

Quality in Sport
Background:  Bouldering is a rapidly growing sport with emerging evidence of health-promoting effects across physical, psychological, and social domains.
Martyna Woźniak, Marcela Słomianny, Karolina Kutnik, Karolina Kusibab, Gabriela Sikora, Michał Czechowski, Katarzyna Gunia, Karolina Koguc, Karolina Kolada, Małgorzata Sajda   +9 more
doaj   +1 more source

Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK/STAT1 signaling pathway

FEBS Open Bio, EarlyView.
We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan, Jingling Huang, Xiang Lin, Tingjiao Lan, Yuli Tang, Ling Sun, Guixuan Zhou   +6 more
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Pull-Up Performance Is Affected Differently by the Muscle Contraction Regimens Practiced during Training among Climbers

Bioengineering
Sport climbing performance is highly related to upper limb strength and endurance. Although finger-specific methods are widely analyzed in the literature, no study has yet quantified the effects of arm-specific training.
Laurent Vigouroux, Marine Devise
doaj   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Effect of an indoor climbing program on selective attention of children with autism spectrum disorder (ASD)

Human Movement
Purpose Children with autism spectrum disorder (ASD) focus their attention more easily through visual support. Indoor climbing requires focus and motor planning that enhance the cognitive functions and attention of children with ASD to follow specific ...
Alexandra Eleftheria Broupi, Dimitrios Kokaridas, Vasileios Tsimaras, Marios Goudas   +3 more
doaj   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

The art of falling: identifying the falls scenarios associated with bouldering injuries

Frontiers in Sports and Active Living
IntroductionBouldering has seen a significant rise in popularity, accompanied by an increase in related injuries, primarily caused by falls. To enhance prevention strategies and improve protective mats, it is crucial to understand the mechanisms behind ...
Erwan Beurienne, Erwan Beurienne, Nicolas Bailly, Maxime Luiggi, Maxime Luiggi, Cécile Martha, Claire Bruna-Rosso, Maxime Wylomanski, Michel Behr, Marine Dorsemaine   +9 more
doaj   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Comparison of Finger Flexor Strength and Muscle Quality Between Climbers and Non-Climbers: Influence of Sex and Grip Type

Applied Sciences
Climbing demands exceptional isometric finger flexor strength and neuromuscular efficiency. This study aimed to compare maximum isometric strength and muscle quality (MQ) between climbers and non-climbers and examine the influence of sex and specific ...
Diego González-Martín, Javier Santos-Pérez, Sergio Maroto-Izquierdo, José Antonio de Paz, Ángel Gallego-Selles   +4 more
doaj   +1 more source