A Pragmatic Approach to Susceptibility Classification of Yeasts without EUCAST Clinical Breakpoints [PDF]
Journal of Fungi, 2022 EUCAST has established clinical breakpoints for the six most common Candida species and Cryptococcus neoformans but not for less common yeasts because sufficient evidence is lacking. Consequently, the question “How to interpret the MIC?” for other yeasts
Karen Marie Thyssen Astvad +2 more
doaj +5 more sources
Radiology and Oncology, 2023 t(14;18)(q32;q21) translocation is an important genetic feature of follicular lymphoma resulting in antiapoptotic B-cell lymphoma 2 (BCL2) protein overexpression. On chromosome 18 breakpoint-site variation is high but does not affect BCL2.
Panjan Matej +4 more
doaj +3 more sources
Clinical Impact of Revised Ciprofloxacin Breakpoint in Patients with Urinary Tract Infections by Enterobacteriaceae [PDF]
Antibiotics, 2021 In 2018, the Clinical and Laboratory Standards Institute (CLSI) revised ciprofloxacin (CIP)-susceptible breakpoint for Enterobacteriaceae from ≤1 μg/mL to ≤0.25 μg/mL, based on pharmacokinetic-pharmacodynamic (PK-PD) analysis.
Ga Eun Park +8 more
doaj +3 more sources
Sequence homology at the breakpoint and clinical phenotype of mitochondrial DNA deletion syndromes. [PDF]
PLoS ONE, 2010 Mitochondrial DNA (mtDNA) deletions are a common cause of mitochondrial disorders. Large mtDNA deletions can lead to a broad spectrum of clinical features with different age of onset, ranging from mild mitochondrial myopathies (MM), progressive external ...
Bekim Sadikovic +8 more
doaj +6 more sources
Correction: Sequence Homology at the Breakpoint and Clinical Phenotype of Mitochondrial DNA Deletion Syndromes. [PDF]
PLoS ONE, 2017 [This corrects the article DOI: 10.1371/journal.pone.0015687.].
Bekim Sadikovic +8 more
doaj +4 more sources
Clinical Breakpoint of Apramycin to Swine Salmonella and Its Effect on Ileum Flora. [PDF]
Int J Mol Sci, 2022 The purpose of this study was to establish the clinical breakpoint (CBP) of apramycin (APR) against Salmonella in swine and evaluate its effect on intestinal microbiota. The CBP was established based on three cutoff values of wild-type cutoff value (COWT), pharmacokinetic-pharmadynamic (PK/PD) cutoff value (COPD) and clinical cutoff value (COCL).
Dai X +6 more
europepmc +4 more sources
Determination of Susceptibility Breakpoint for Cefquinome against Streptococcus suis in Pigs
Antibiotics, 2021 Streptococcus suis (S. suis), a zoonotic pathogen, causes severe diseases in both pigs and human beings. Cefquinome can display excellent antibacterial activity against gram-negative and gram-positive bacteria.
Kun Mi +9 more
doaj +1 more source
Establishing Antimicrobial Susceptibility Testing Methods and Clinical Breakpoints for Inhaled Antibiotic Therapy [PDF]
Open Forum Infectious Diseases, 2022 Abstract Inhaled antibiotics are a common and valuable therapy for patients suffering from chronic lung infection, with this particularly well demonstrated for patients with cystic fibrosis. However, in vitro tests to predict patient response to inhaled antibiotic therapy are currently lacking.
Miquel B Ekkelenkamp +5 more
openaire +6 more sources
Frontiers in Veterinary Science, 2021 Background: Data regarding antimicrobial pharmacokinetics (PK) in critically ill dogs are lacking and likely differ from those of healthy dogs. The aim of this work is to describe a population PK model for intravenous (IV) amoxicillin–clavulanic acid ...
Maria D. Vegas Cómitre +9 more
doaj +1 more source