Evidence for Establishing the Clinical Breakpoint of Cefquinome against Haemophilus Parasuis in China. [PDF]
Pathogens, 2021 Haemophilus parasuis can cause high morbidity and mortality in swine. Cefquinome possesses excellent antibacterial activity against pathogens causing diseases of the respiratory tract.
Mi K +7 more
europepmc +5 more sources
Exploration of Clinical Breakpoint of Danofloxacin for Glaesserella parasuis in Plasma and in PELF. [PDF]
Antibiotics (Basel), 2021 Background: In order to establish the clinical breakpoint (CBP) of danofloxacin against G. parasuis, three cutoff values, including epidemiological cutoff value (ECV), pharmacokinetic-pharmacodynamic (PK-PD) cutoff value (COPD) and clinical cutoff value (
Xu Z +12 more
europepmc +6 more sources
Optimal Regimens and Clinical Breakpoint of Avilamycin Against Clostridium perfringens in Swine Based on PK-PD Study. [PDF]
Front Pharmacol, 2022 Clostridium perfringens causes significant morbidity and mortality in swine worldwide. Avilamycin showed no cross resistance and good activity for treatment of C. perfringens.
Huang A +10 more
europepmc +2 more sources
Rational Use of Danofloxacin for Treatment of Mycoplasma gallisepticum in Chickens Based on the Clinical Breakpoint and Lung Microbiota Shift. [PDF]
Antibiotics (Basel), 2022 The study was to explore the rational use of danofloxacin against Mycoplasma gallisepticum (MG) based on its clinical breakpoint (CBP) and the effect on lung microbiota.
Wang S +11 more
europepmc +2 more sources
Prudent Use of Tylosin for Treatment of Mycoplasma gallisepticum Based on Its Clinical Breakpoint and Lung Microbiota Shift. [PDF]
Front Microbiol, 2021 The aim of this study was to explore the prudent use of tylosin for the treatment of chronic respiratory infectious diseases in chickens caused by Mycoplasma gallisepticum (MG) based on its clinical breakpoint (CBP) and its effect on lung microbiota. The
Huang A +10 more
europepmc +2 more sources
A Pragmatic Approach to Susceptibility Classification of Yeasts without EUCAST Clinical Breakpoints [PDF]
Journal of Fungi, 2022 EUCAST has established clinical breakpoints for the six most common Candida species and Cryptococcus neoformans but not for less common yeasts because sufficient evidence is lacking. Consequently, the question “How to interpret the MIC?” for other yeasts
Karen Marie Thyssen Astvad +2 more
doaj +5 more sources
Radiology and Oncology, 2023 t(14;18)(q32;q21) translocation is an important genetic feature of follicular lymphoma resulting in antiapoptotic B-cell lymphoma 2 (BCL2) protein overexpression. On chromosome 18 breakpoint-site variation is high but does not affect BCL2.
Panjan Matej +4 more
doaj +3 more sources
Clinical Impact of Revised Ciprofloxacin Breakpoint in Patients with Urinary Tract Infections by Enterobacteriaceae [PDF]
Antibiotics, 2021 In 2018, the Clinical and Laboratory Standards Institute (CLSI) revised ciprofloxacin (CIP)-susceptible breakpoint for Enterobacteriaceae from ≤1 μg/mL to ≤0.25 μg/mL, based on pharmacokinetic-pharmacodynamic (PK-PD) analysis.
Ga Eun Park +8 more
doaj +3 more sources
Sequence homology at the breakpoint and clinical phenotype of mitochondrial DNA deletion syndromes. [PDF]
PLoS ONE, 2010 Mitochondrial DNA (mtDNA) deletions are a common cause of mitochondrial disorders. Large mtDNA deletions can lead to a broad spectrum of clinical features with different age of onset, ranging from mild mitochondrial myopathies (MM), progressive external ...
Bekim Sadikovic +8 more
doaj +6 more sources
Assessment of long-read strategies for the enrichment of clinically relevant breakpoints in lymphomas: towards a diagnostic implementation. [PDF]
Ann HematolRecurrent chromosomal translocations are hallmarks of many hematological malignancies, including lymphomas and leukemias. Accurate breakpoint detection is essential for diagnostics, treatment optimization, and disease monitoring.
Pardy F +6 more
europepmc +2 more sources