Results 21 to 30 of about 67,375 (266)

Correction: Sequence Homology at the Breakpoint and Clinical Phenotype of Mitochondrial DNA Deletion Syndromes. [PDF]

PLoS ONE, 2017
[This corrects the article DOI: 10.1371/journal.pone.0015687.].
Bekim Sadikovic, Jing Wang, Ayman W El-Hattab, Megan Landsverk, Ganka Douglas, Ellen K Brundage, William J Craigen, Eric S Schmitt, Lee-Jun C Wong   +8 more
doaj   +4 more sources

Clinical Breakpoint of Apramycin to Swine Salmonella and Its Effect on Ileum Flora. [PDF]

Int J Mol Sci, 2022
The purpose of this study was to establish the clinical breakpoint (CBP) of apramycin (APR) against Salmonella in swine and evaluate its effect on intestinal microbiota. The CBP was established based on three cutoff values of wild-type cutoff value (COWT), pharmacokinetic-pharmadynamic (PK/PD) cutoff value (COPD) and clinical cutoff value (COCL).
Dai X, Gu Y, Guo J, Huang L, Cheng G, Peng D, Hao H.   +6 more
europepmc   +4 more sources

High-Dose Minocycline Improves Outcomes in Acinetobacter baumannii Group Pneumonia: A Propensity-Weighted Cohort Study with MIC-Based Insights for Breakpoint Revision. [PDF]

Infect Dis Ther
Introduction Optimal minocycline dosing for Acinetobacter baumannii group pneumonia remains unclear. We assessed the clinical impact of high-dose (HD) versus standard-dose (SD) minocycline and explored the predictive value of susceptibility breakpoints ...
Tseng YT, Chen YC, Lee YT, Liao PH, Chiang DH, Chen PL, Huang TW, Wang YC.   +7 more
europepmc   +2 more sources

Diagnostic utility of GenoType MTBDRsl assay for the detection of moxifloxacin-resistant mycobacterium tuberculosis, as compared to phenotypic method and whole-genome sequencing

International Journal of Mycobacteriology, 2022
Background: Recently, moxifloxacin (MFX)-resistant results of Mycobacterium tuberculosis (Mtb) obtained by GenoType MTBDRsl (second-line line probe assay [SL-LPA]) have been stratified to determine their resistance level; however, its accuracy has not ...
Raj Narayan Yadav, Manpreet Bhalla, Gavish Kumar, Grish C Sah, Ravindra Kumar Dewan, Ritu Singhal   +5 more
doaj   +1 more source

Determination of Susceptibility Breakpoint for Cefquinome against Streptococcus suis in Pigs

Antibiotics, 2021
Streptococcus suis (S. suis), a zoonotic pathogen, causes severe diseases in both pigs and human beings. Cefquinome can display excellent antibacterial activity against gram-negative and gram-positive bacteria.
Kun Mi, Mei Li, Lei Sun, Yixuan Hou, Kaixiang Zhou, Haihong Hao, Yuanhu Pan, Zhenli Liu, Changqing Xie, Lingli Huang   +9 more
doaj   +1 more source

Evaluations of Antifungal Susceptibilities Have to Be According to Reference Guidelines: CLSI and EUCAST

Van Tıp Dergisi, 2022
Editöre mektup olduğundan özet ...
Ali Korhan Sığ
doaj   +1 more source

Establishing Antimicrobial Susceptibility Testing Methods and Clinical Breakpoints for Inhaled Antibiotic Therapy [PDF]

Open Forum Infectious Diseases, 2022
Abstract Inhaled antibiotics are a common and valuable therapy for patients suffering from chronic lung infection, with this particularly well demonstrated for patients with cystic fibrosis. However, in vitro tests to predict patient response to inhaled antibiotic therapy are currently lacking.
Miquel B Ekkelenkamp, María Díez-Aguilar, Michael M Tunney, J Stuart Elborn, Ad C Fluit, Rafael Cantón   +5 more
openaire   +6 more sources

Clinical and genetic characterisation of dystrophin-deficient muscular dystrophy in a family of Miniature Poodle dogs [PDF]

, 2018
Four full-sibling intact male Miniature Poodles were evaluated at 4–19 months of age. One was clinically normal and three were affected. All affected dogs were reluctant to exercise and had generalised muscle atrophy, a stiff gait and a markedly elevated
A Aartsma-Rus, A McKenna, Alberta de Stefani, Anita Shea, AP Monaco, AV Winnard, BA Valentine, BF Smith, BJ Cooper, C Le Guiner, C Pichavant, CA Collins, CA Jenkins, CA Wetterman, Carlos E. Ambrósio, CT Caskey, DE Cole, DJ VanBelzen, Elsa Beltrán, EM Hoogerwaard, EM Hoogerwaard, EP Hoffman, F Daoud, G Anil, G Bulfield, G. Diane Shelton, GD Shelton, GD Shelton, GD Shelton, GD Shelton, GL Walmsley, H Li, JA Goldstein, JL Carpenter, JN Kornegay, JN Kornegay, JR Mendell, JW McGreevy, K Bushby, K Nakamura, KJ Livak, KJ Nowak, Ling T. Guo, Lluís Sánchez, Louise M. Burmeister, LT Guo, Luisa De Risio, M Koenig, N Klymiuk, N Winand, NJ Olby, NJ Sharp, PP Nghiem, S Atencia-Fernandez, S Pouwels, S Rozen, SJ Schatzberg, SJ Schatzberg, T Larcher, U Francke, V Dubowitz, V Ricotti, W El Nemer, WI Baltzer   +63 more
core   +11 more sources

Population Pharmacokinetics of Intravenous Amoxicillin Combined With Clavulanic Acid in Healthy and Critically Ill Dogs

Frontiers in Veterinary Science, 2021
Background: Data regarding antimicrobial pharmacokinetics (PK) in critically ill dogs are lacking and likely differ from those of healthy dogs. The aim of this work is to describe a population PK model for intravenous (IV) amoxicillin–clavulanic acid ...
Maria D. Vegas Cómitre, Stefano Cortellini, Marc Cherlet, Mathias Devreese, Beatrice B. Roques, Alain Bousquet-Melou, Pierre-Louis Toutain, Pierre-Louis Toutain, Ludovic Pelligand, Ludovic Pelligand   +9 more
doaj   +1 more source

Intronic Breakpoint Signatures Enhance Detection and Characterization of Clinically Relevant Germline Structural Variants [PDF]

The Journal of Molecular Diagnostics, 2021
The relevance of large copy number variants (CNVs) to hereditary disorders has been long recognized, and population sequencing efforts have chronicled many common structural variants (SVs). However, limited data are available on the clinical contribution of rare germline SVs.
Jeroen van den Akker, Lawrence Hon, Anjana Ondov, Ziga Mahkovec, Robert O'Connor, Raymond C. Chan, Justin Lock, Anjali D. Zimmer, Asha Rostamianfar, Jeremy Ginsberg, Annette Leon, Scott Topper   +11 more
openaire   +2 more sources