Intronic Breakpoint Signatures Enhance Detection and Characterization of Clinically Relevant Germline Structural Variants [PDF]
The Journal of Molecular Diagnostics, 2021 The relevance of large copy number variants (CNVs) to hereditary disorders has been long recognized, and population sequencing efforts have chronicled many common structural variants (SVs). However, limited data are available on the clinical contribution of rare germline SVs.
Jeroen van den Akker +11 more
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Updated EUCAST Clinical Breakpoints against Aspergillus, Implications for the Clinical Microbiology Laboratory [PDF]
Journal of Fungi, 2020 Azole resistance poses a problem for the management of patients with invasive aspergillosis. Former species are in fact groups of closely related species (or complexes); cryptic species frequently show high antifungal resistance. The European Committee on Antimicrobial Susceptibility Testing (EUCAST) Definitive Document (E.Def) 9.3.2 includes ...
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Understanding and Addressing CLSI Breakpoint Revisions: a Primer for Clinical Laboratories [PDF]
Journal of Clinical Microbiology, 2019 The Clinical and Laboratory Standards Institute (CLSI) has revised several breakpoints since 2010 for bacteria that grow aerobically. In 2019, these revisions include changes to the ciprofloxacin and levofloxacin breakpoints for the Enterobacteriaceae and Pseudomonas aeruginosa , daptomycin ...
Romney M, Humphries +2 more
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Cephalexin susceptibility breakpoint for veterinary isolates: Clinical Laboratory Standards Institute revision [PDF]
Journal of Veterinary Diagnostic Investigation, 2017 The Clinical and Laboratory Standards Institute (CLSI) uses cephalothin as the class representative for testing veterinary isolates for susceptibility to other first-generation cephalosporins, including cephalexin. We examined replacing cephalothin with cephalexin because cephalexin is used more often clinically.
Mark G, Papich, Cindy, Lindeman
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BMC Medicine, 2022 Background Diverse genomic breakpoints of fusions that localize to intronic, exonic, or intergenic regions have been identified by DNA next-generation sequencing (NGS), but the role of exonic breakpoints remains elusive.
Weihua Li +6 more
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Frontiers in Genetics, 2022 Expanded carrier screening (ECS) has become an increasingly common technique to assess the genetic risks of individuals in the prenatal or preconception period.
Ying Bai +9 more
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Pharmacodynamic Thresholds for Beta-Lactam Antibiotics: A Story of Mouse Versus Man
Frontiers in Pharmacology, 2022 Beta-lactams remain a critical member of our antibiotic armamentarium and are among the most commonly prescribed antibiotic classes in the inpatient setting.
Angela V. Berry, Joseph L. Kuti
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The continued value of disk diffusion for assessing antimicrobial susceptibility in clinical laboratories: Report from the Clinical and Laboratory Standards Institute Methods Development and Standardization Working Group [PDF]
, 2018 Expedited pathways to antimicrobial agent approval by the U.S. Food and Drug Administration (FDA) have led to increased delays between drug approval and the availability of FDA-cleared antimicrobial susceptibility testing (AST) devices.
Burnham, Carey-Ann D +6 more
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Clinical breakpoint meropenem concentration modulate outer membrane vesicle production in enterotoxigenic Bacteroides fragilis. [PDF]
Arch MicrobiolKozhakhmetova S +9 more
europepmc +2 more sources
Adding a reward increases the reinforcing value of fruit [PDF]
, 2017 Adolescents' snack choices could be altered by increasing the reinforcing value (RV) of healthy snacks compared with unhealthy snacks. This study assessed whether the RV of fruit increased by linking it to a reward and if this increased RV was comparable
Beullens, Kathleen +14 more
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