Results 31 to 40 of about 67,375 (266)

Updated EUCAST Clinical Breakpoints against Aspergillus, Implications for the Clinical Microbiology Laboratory [PDF]

Journal of Fungi, 2020
Azole resistance poses a problem for the management of patients with invasive aspergillosis. Former species are in fact groups of closely related species (or complexes); cryptic species frequently show high antifungal resistance. The European Committee on Antimicrobial Susceptibility Testing (EUCAST) Definitive Document (E.Def) 9.3.2 includes ...
openaire   +4 more sources

Understanding and Addressing CLSI Breakpoint Revisions: a Primer for Clinical Laboratories [PDF]

Journal of Clinical Microbiology, 2019
The Clinical and Laboratory Standards Institute (CLSI) has revised several breakpoints since 2010 for bacteria that grow aerobically. In 2019, these revisions include changes to the ciprofloxacin and levofloxacin breakpoints for the Enterobacteriaceae and Pseudomonas aeruginosa , daptomycin ...
Romney M, Humphries, April N, Abbott, Janet A, Hindler   +2 more
openaire   +2 more sources

Cephalexin susceptibility breakpoint for veterinary isolates: Clinical Laboratory Standards Institute revision [PDF]

Journal of Veterinary Diagnostic Investigation, 2017
The Clinical and Laboratory Standards Institute (CLSI) uses cephalothin as the class representative for testing veterinary isolates for susceptibility to other first-generation cephalosporins, including cephalexin. We examined replacing cephalothin with cephalexin because cephalexin is used more often clinically.
Mark G, Papich, Cindy, Lindeman
openaire   +2 more sources

Reliability analysis of exonic-breakpoint fusions identified by DNA sequencing for predicting the efficacy of targeted therapy in non-small cell lung cancer

BMC Medicine, 2022
Background Diverse genomic breakpoints of fusions that localize to intronic, exonic, or intergenic regions have been identified by DNA next-generation sequencing (NGS), but the role of exonic breakpoints remains elusive.
Weihua Li, Rui Wan, Lei Guo, Geyun Chang, Dong Jiang, Lin Meng, Jianming Ying   +6 more
doaj   +1 more source

Long-Read Sequencing Revealed Extragenic and Intragenic Duplications of Exons 56–61 in DMD in an Asymptomatic Male and a DMD Patient

Frontiers in Genetics, 2022
Expanded carrier screening (ECS) has become an increasingly common technique to assess the genetic risks of individuals in the prenatal or preconception period.
Ying Bai, Ju Liu, Jinghan Xu, Yue Sun, Jingjing Li, Yong Gao, Lina Liu, Cangcang Jia, Xiangdong Kong, Li Wang   +9 more
doaj   +1 more source

Pharmacodynamic Thresholds for Beta-Lactam Antibiotics: A Story of Mouse Versus Man

Frontiers in Pharmacology, 2022
Beta-lactams remain a critical member of our antibiotic armamentarium and are among the most commonly prescribed antibiotic classes in the inpatient setting.
Angela V. Berry, Joseph L. Kuti
doaj   +1 more source

The continued value of disk diffusion for assessing antimicrobial susceptibility in clinical laboratories: Report from the Clinical and Laboratory Standards Institute Methods Development and Standardization Working Group [PDF]

, 2018
Expedited pathways to antimicrobial agent approval by the U.S. Food and Drug Administration (FDA) have led to increased delays between drug approval and the availability of FDA-cleared antimicrobial susceptibility testing (AST) devices.
Burnham, Carey-Ann D, Ferrell, Andrea, Hsiung, Andre, Humphries, Romney M, Kircher, Susan, Krause, Kevin M, Malherbe, Rianna   +6 more
core   +2 more sources

Clinical breakpoint meropenem concentration modulate outer membrane vesicle production in enterotoxigenic Bacteroides fragilis. [PDF]

Arch Microbiol
Kozhakhmetova S, Bekbayeva A, Zholdybayeva E, Krivoruchko T, Dashevskaya N, Vinogradova E, Kamzayeva N, Khassenbekova Z, Kushugulova A, Kozhakhmetov S.   +9 more
europepmc   +2 more sources

Pharmacokinetic/pharmacodynamic integration and modelling of oxytetracycline for the porcine pneumonia pathogens Actinobacillus pleuropneumoniae and Pasteurella multocida [PDF]

, 2017
Pharmacokinetic–pharmacodynamic (PK/PD) integration and modelling were used to predict dosage schedules of oxytetracycline for two pig pneumonia pathogens, Actinobacillus pleuropneumoniae and Pasteurella multocida.
Aliabadi, Aliabadi, Blondeau, Brentnall, Brentnall, Cadwell, Dorey, Honeyman, Illambas, Illambas, Jong, Lees, Lees, Lees, Lees, Martinez, Mouton, Mouton, Nielsen, Nielsen, Nightingale, Nouws, Nouws, Nyberg, Papich, Potter, Rey, Sidhu, Sidhu, Toutain, Toutain, Toutain, Toutain, Vilalta, Yoshimura   +34 more
core   +2 more sources

Rapid mapping of chromosomal breakpoints: from blood to BAC in 20 days [PDF]

, 2009
Structural chromosome aberrations and associated segmental or chromosomal aneusomies are major causes of reproductive failure in humans. Despite the fact that carriers of reciprocal balanced translocation often have no other clinical symptoms or ...
Baumgartner, Adolf, Escudero, Tomas, Kwan, Johnson, Lu, Chun-Mei, Munné, Santiago, Wang, Mei, Weier, Heinz-Ulrich G., Weier, Jingly F.   +7 more
core   +2 more sources