Results 51 to 60 of about 517,662 (262)

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Navigating preanalytical challenges: a real-world study on single-tube pneumatic tube systems

Frontiers in Physiology
PurposePneumatic tube systems (PTS) accelerate the transport of samples in the laboratory but may lead to preanalytical hemolysis. Samples may rest before transport during busy times, but the effect on test accuracy is unclear.
Lisha Li, Xiaofei Zhang, Nannan Xu, Miaoli Shao, Binxuan Chen, Feng Wu, Qi Zhao, Wensheng Wang, Jianxin Yan, Zhiheng Wang, Renfang Zhou   +10 more
doaj   +1 more source

Porous Bead-Based Diagnostic Platforms: Bridging the Gaps in Healthcare

Sensors, 2012
Advances in lab-on-a-chip systems have strong potential for multiplexed detection of a wide range of analytes with reduced sample and reagent volume; lower costs and shorter analysis times.
John McDevitt, Ximena Sanchez, Pierre N. Floriano, Nicolaos Christodoulides, Jie Chou, Jorge Wong   +5 more
doaj   +1 more source

Accuracy in Clinical Chemistry

Clinical Chemistry, 1971
Abstract Improved accuracy of clinical laboratory measurements requires a broad range concept of quality control. Items considered include standardization, precision, specificity, recovery studies, interlaboratory comparisons, and long-range stability of laboratory performance.
openaire   +2 more sources

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Porcine Hepatic Response to Fumonisin B₁ in a Short Exposure Period: Fatty Acid Profile and Clinical Investigations

Toxins, 2019
Scarce studies have investigated the impact of fumonisin B1 (FB1) on the hepatic tissue fatty acid (FA) profile, and no study is available on piglets. A 10-day in vivo experiment was performed on seven piglets/group: control and FB1-fed animals (diet was
Omeralfaroug Ali, Judit Szabó-Fodor, Hedvig Fébel, Miklós Mézes, Krisztián Balogh, Róbert Glávits, Melinda Kovács, Arianna Zantomasi, András Szabó   +8 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Reference values of clinical pathology parameters in cynomolgus monkeys (Macaca fascicularis) used in preclinical studies

Laboratory Animal Research, 2016
Nonhuman primates are increasingly used in biomedical research since they are highly homologous to humans compared to other rodent animals. However, there is limited reliable reference data of the clinical pathology parameters in cynomolgus monkeys, and ...
Hyun-Kyu Park, Jae-Woo Cho, Byoung-Seok Lee, Heejin Park, Ji-Seok Han, Mi-Jin Yang, Wan-Jung Im, Do-Yong Park, Woo-Jin Kim, Su-Cheol Han, Yong-Bum Kim   +10 more
doaj   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source