Results 51 to 60 of about 8,108,152 (305)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Dynamic Combinatorial Libraries: From Exploring Molecular Recognition to Systems Chemistry [PDF]

, 2013
Dynamic combinatorial chemistry (DCC) is a subset of combinatorial chemistry where the library members interconvert continuously by exchanging building blocks with each other.
Otto, Sijbren,, Otto, Sijbren; id_orcid, Jianwei Li, Nowak, Piotr,, Li, Jianwei,, Piotr Nowak, Sijbren Otto, Otto, Sijbren, Li, Jianwei, Nowak, Piotr   +9 more
core   +1 more source

Differential organ responses to fumonisins in rabbits: kidney, liver, and spleen membrane fatty acid composition, oxidation markers, and histopathology

Frontiers in Veterinary Science
The study assessed the kidney, liver, and spleen of adult male rabbits (n = 10/group) in relation to fumonisin B series exposure (10 and 20 mg FB1 + FB2 + FB3/kg feed) over a period of 65 days.
Omeralfaroug Ali, Edward Agyarko, Zsolt Gerencsér, Krisztián Balogh, Miklós Mézes, Melinda Kovács, Melinda Kovács, Mohamed Maki, Noureddine Besselma, Haruna Gado Yakubu, András Szabó, András Szabó   +11 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Nutritional status in patients with cutaneous leishmaniasis and a study of the effects of zinc supplementation together with antimony treatment

Food & Nutrition Research, 2014
Background: The role of micronutrient status for the incidence and clinical course of cutaneous leishmaniasis is not much studied. Still zinc supplementation in leishmaniasis has shown some effect on the clinical recovery, but the evidence in humans is ...
Miguel Guzman-Rivero, Ernesto Rojas, Aleida Verduguez-Orellana, Henry Pardo, Mary Cruz Torrico, Lieselotte Cloetens, Björn Åkesson, Edgar Sejas   +7 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Themed series in organo-fluorine chemistry [PDF]

, 2008
Peer ...
David O'Hagan, O'Hagan, David
core   +1 more source

Beyond Lesions: Systemic Inflammatory and Metabolic Characterization of Swine Inflammation and Necrosis Syndrome

Animals
Swine Inflammation and Necrosis Syndrome (SINS) is characterized by multifocal inflammatory lesions in pigs of different ages and has been associated with systemic inflammatory processes.
Karien Koenders-van Gog, Eveline van Langen-Willems, Henriëtte Brouwer-Middelesch, Gerald Reiner   +3 more
doaj   +1 more source

Intracellular Clinical Chemistry

Clinical Chemistry, 1972
Abstract The plasma compartment, on which almost all routine analyses in clinical chemistry are performed, occupies only a small part of the body, most of which consists of cells. For most components the intracellular and extracellular compartments have a different composition in health, and change differently in disease.
openaire   +2 more sources

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source