Results 21 to 30 of about 198,253 (268)

Economic stress and condescending treatment in childhood and adult self-rated health: results from a population study in Sweden

open access: yesBMC Public Health, 2017
Background Even today, 12% of the children in Sweden live in poverty and many children are exposed to adverse experiences, such as being bullied, which may have long-term consequences on public health.
Fredrik Granström   +2 more
doaj   +1 more source

Cost analysis of informal care: estimates from a national cross-sectional survey in Sweden

open access: yesBMC Health Services Research, 2021
Background Over the past decades, informal care has increased in most OECD-countries. Informal care is costly to caregivers and to society in the form of lost income and direct costs of providing care.
Björn Ekman   +4 more
doaj   +1 more source

Pharmacokinetics of anti-infective agents during CytoSorb hemoadsorption

open access: yesScientific Reports, 2021
Cytokine hemoadsorption might be beneficial in patients with sepsis. However, its effect on anti-infective agents' disposition remains largely unknown.
Antoine G. Schneider   +6 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Assessment of Clinical Competence

open access: yesProgrammed Learning and Educational Technology, 1979
Abstract Current approaches to the examination of clinical competence at the undergraduate level are reviewed and differences in the approaches adopted in Australasia, Britain and North America are mentioned. The test methods used in these examinations are discussed critically and their separate strengths and weaknesses highlighted.
openaire   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Pilot study of safety and efficacy of polyprenols in combination with coenzyme Q10 in patients with statin-induced myopathy

open access: yesMedicina, 2016
Background and objective: Statin-induced myopathy (SIM) has been partially attributed to deficiency of dolichol and coenzyme Q10 (CoQ10). We aimed to test the safety and efficacy of plant polyprenols in combination with CoQ10 for alleviation of SIM ...
Gustavs Latkovskis   +6 more
doaj   +1 more source

The development of an evaluation tool to assess professional behavior and clinical competencies from the graduates’ perspective [PDF]

open access: yesKorean Journal of Medical Education, 2020
Purpose This study was designed to develop an evaluation tool for assessing professional behavior and clinical competencies from the graduates’ perspective. Methods This study employed mixed method in a sequential exploratory design.
Mia Kusmiati   +4 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

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