Results 101 to 110 of about 677,579 (283)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Continuous Vital Signs Monitoring with a Wireless and Wearable Earsensor in Surgical Patients: A Clinical Validation Study

Sensors
(1) Background: Evidence on the clinical accuracy of wireless photoplethysmography (PPG)-based vital sign monitoring is limited. This study evaluated the accuracy, technical performance, and patient comfort of a novel PPG-based earsensor for measuring ...
Patrick van den Berge, Kim van Loon, Lianne Zevenbergen, Pascalle A. van den Heuvel, Martine J. M. Breteler   +4 more
doaj   +1 more source

Excessive growth hormone expression in male GH transgenic mice adversely alters bone architecture and mechanical strength [PDF]

, 2015
Patients with acromegaly have a higher prevalence of vertebral fractures despite normal bone mineral density (BMD), suggesting that GH overexpression has adverse effects on skeletal architecture and strength. We used giant bovine GH (bGH) transgenic mice
Chavassieux, P, Chenu, C, Hopkinson, M, Javaheri, B, Kopchick, J, Korbonits, M, Lim, SV, List, E, Marenzana, M, Pereira, M, Roux, J   +10 more
core   +4 more sources

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Predicting Deterioration in Patients With Normotensive Acute Pulmonary Embolism Using Clinical‐Imaging Features: A Multicenter Prospective Cohort Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Prioritization of management strategies in patients with normotensive acute pulmonary embolism is based on the identification of individuals at risk for early deterioration.
Yizhuo Gao, Shibo Wei, Yuchen Liu, Zhenglun Yu, Shanshan Zhan, Binze Yang, Chuanxin Qi, Shougang Qi, Minggang Wang, Dong Jia   +9 more
doaj   +1 more source

Treatment dilemmas in a young man presenting with narcolepsy and psychotic symptoms. [PDF]

, 2011
Psychotic features can be present in both narcolepsy and psychosis, which can result in challenges in diagnosis and management. The prevalence of both conditions is low and the reports in young people are scarce. Our report illustrates the relevance of a
Davies, S, Fernandez, V, Walters, N
core   +2 more sources

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Predictors of in-hospital mortality in patients requiring transfer to the medical intensive care unit

Journal of the Pakistan Medical Association
Objective: To identify the factors associated with higher odds of in-hospital mortality among inpatients requiring transfer to the medical intensive care unit.
Huzefa Jibril, Muhammad Azhar, Ainan Arshad, Safia Awan, Syed Ahsan Ali, Muhammed Tariq   +5 more
doaj   +1 more source

The effects of short-term omission of daily medication on the pathophysiology of heart failure [PDF]

, 2016
Aims Pharmacological therapies for heart failure (HF) aim to improve congestion, symptoms, and prognosis. Failing to take medication is a potential cause of worsening HF.
Abraham, Abraham, Amir, Brunner-La Rocca, Buendia, Cleland, Cole, Cotter, Cotter, Dalen, Darling, DiMatteo, Dovancescu, Dovancescu, Galve, Good, Grinstead, Gundersen, Ho, Hope, Inglis, Kraaij, Maisel, Mentz, O'Connor, Osterberg, Pellicori, Pellicori, Platz, Shochat, Wal, Weyer   +31 more
core   +4 more sources

MRI Deterioration in Herpes Simplex Encephalitis Despite Clinical Recovery

The Neurologist, 2009
Herpes simplex virus type 1 is a sporadic cause of viral encephalitis. Relapse of encephalitis occurs in up to 10% of patients, manifested by recurrent symptoms, clinical and MRI findings, and the presence of herpes simplex virus type 1 DNA in the cerebrospinal fluid (CSF).We describe the clinical features, MRI findings and outcome in 2 patients with ...
Markoula, S., Giannopoulos, S., Pelidou, S. H., Argyropoulou, M., Lagos, G., Kyritsis, A. P.   +5 more
openaire   +3 more sources