Results 121 to 130 of about 677,579 (283)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Quality of life and symptom intensity over time in people with cancer receiving palliative care : results from the international European Palliative Care Cancer Symptom study [PDF]

, 2019
Background People with advanced cancer experience multiple symptoms during their illness trajectory, which can fluctuate in intensity. Aim To describe the course of self-reported quality of life, emotional functioning, physical functioning and symptom ...
Deliens, Luc, Hjermstad, Marianne J, Kaasa, Stein, Pardon, Koen, Van Belle, Simon, Verkissen, Mariette   +5 more
core   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Interleukin-22 predicts severity and death in advanced liver cirrhosis: a prospective cohort study [PDF]

, 2012
Background: Interleukin-22 (IL-22), recently identified as a crucial parameter of pathology in experimental liver damage, may determine survival in clinical end-stage liver disease.
Bachmann, Malte, Brunner, Friederike, Filmann, Natalie, Herrmann, Eva, Kapper, Lisa, Kronenberger, Bernd, Mühl, Heiko, Pfeilschifter, Josef Martin (Prof. Dr.), Piiper, Albrecht, Rudloff, Ina, Waidmann, Oliver, Zeuzem, Stefan   +11 more
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Setting the Next Vital Sign Observation Interval as a Learning Objective in Simulation-Based Nursing Education: A Prospective Exploratory Observational Study

Nursing Reports
Background/Objectives: Abnormal vital signs often precede in-hospital clinical deterioration, but little is known about how nurses decide when to recheck vital signs.
Keisuke Endo, Kazumi Kubota, Kenji Karino, Rie Sato, Seiko Miura, Yasunori Ueda, Yoshiaki Iwashita   +6 more
doaj   +1 more source

Is 24 hour observation in hospital after stopping intravenous antibiotics in neonates justified? [PDF]

, 2009
Background: Antibiotics are given empirically for suspected sepsis in up to 75% of neonates on the Neonatal and Paediatric Intensive Care Unit (NPICU), after completion of a septic screen. Treatment is discontinued on day 3 if cultures remain negative or
Andrejevic, Hermoine, Attard Montalto, Simon, Fenech, Josella, Said Conti, Valerie   +3 more
core  

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Night Physician–Nurse Collaboration: Developing the Scale of Physicians’ Difficulties and Exploring Related Factors in Acute Care Hospitals

Journal of Multidisciplinary Healthcare
Soichiro Hotta,1 Kaoru Ashida,2 Makoto Tanaka1 1Department of Adult Health Nursing, Graduate School of Health Care Sciences, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo, Japan; 2Department of Nursing, College of Nursing, Kanto Gakuin University,
Hotta S, Ashida K, Tanaka M
doaj  

Clinical Effectiveness of an Artificial Intelligence-Based Prediction Model for Cardiac Arrest in General Ward-Admitted Patients: A Non-Randomized Controlled Trial

Diagnostics
Background: Ward patients who experience clinical deterioration are at high risk of mortality. Conventional rapid response systems (RRS) using track-and-trigger protocols have not consistently demonstrated improved outcomes.
Mi Hwa Park, Mincheol Kim, Man-Jong Lee, Ah Jin Kim, Kyung-Jae Cho, Jinhui Jang, Jaehun Jung, Mineok Chang, Dongjoon Yoo, Jung Soo Kim   +9 more
doaj   +1 more source