Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Improvement of Surgical Technologist Students' Learning by Development of a Customized e-portfolio: A Mixed-method Study [PDF]
Strides in Development of Medical EducationBackground: Electronic portfolios provide opportunities for students to reflect on their performance and develop their competencies.Objectives: The present study was done to improve surgical technologist students' learning through the development of a ...
Leila Sadati +5 more
doaj +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
Clinical supervision manual: for the supervisor of the paraprofessional counsellor [PDF]
, 2019 Clinical supervision has moved to the forefront of research as its value has become recognized. However, the practice of competent supervision is only recently become operationalized and many counsellors still receive inadequate supervision by ...
Ebing, Bridgette +1 more
core
An Introduction to some new approaches in clinical education [PDF]
مجله ایرانی آموزش در علوم پزشکی, 2011 Introduction: Clinical education is one of the most important and crucial parts of health science education. Successful clinical education needs to adopt effective approaches that are based on up to date knowledge, clients’ and patients’ needs. Therefore,
Fariba Haghani, Mousa Alavi
doaj
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
A Critical Review on Communication Paradigms Beteween Academic and Clinical Service Institutions in Nursing [PDF]
مجله ایرانی آموزش در علوم پزشکی, 2012 Introduction: Clinical education is the duty of academic and clinical organizations and its effectiveness is influenced by the interaction of both organizations.
Fatemeh Heshmati Nabavi +2 more
doaj
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
The Challenges of Nursing Procedures Training from the Perspective of Nursing Students: A Qualitative Study [PDF]
Strides in Development of Medical Education, 2016 Background & Objective: In nursing clinical education due to its importance is known as the heart of professional education One of the skills taught in the clinical environment is nursing procedures Studies show that even students who have complete ...
Saba Farzi +2 more
doaj