Results 91 to 100 of about 583,827 (328)
Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch +16 morewiley +1 more sourceEffect of natalizumab on disease progression in secondary progressive multiple sclerosis (ASCEND). a phase 3, randomised, double-blind, placebo-controlled trial with an open-label extension [PDF]
, 2018 Background: Although several disease-modifying treatments are available for relapsing multiple sclerosis, treatment effects have been more modest in progressive multiple sclerosis and have been observed particularly in actively relapsing subgroups or ...Achiron, Anat, Airas, Laura, Al Khedr, Abdullatif, Alvarez Cermeño, Jose Carlos, Arnold, Douglas L, Ayuso, Guillermo Izquierdo, Bandari, Daniel, Bartholomé, Emmanuel, Baum, Karl, Bergamaschi, Roberto, Berger, Joseph, Berthele, Achim, Bhan, Virender, Blevins, Gregg, Boyko, Alexey, Brassat, David, Brochet, Bruno, Brunet, Donald, Cadavid, Diego, Camac, Ann, Campbell, Nolan, Camu, William, Chang, Ih, Chefranova, Zanna, Cohan, Stanley, Comi, Giancarlo, Conway, Jill, Cottone, Salvatore, Czarnecki, Maciej, D'Hooghe, Marie, Debouverie, Marc, Devonshire, Virginia, Deykin, Aaron, Drozdowski, Wieslaw, Duddy, Martin, Dufek, Michal, Duquette, Pierre, Edwards, Keith, Elovaara, Irina, Eralinna, Juha-Pekka, Escartin, Antonio, Evdoshenko, Evgeny, Fabian, Michelle, Faiss, Juergen, Fernandez, Oscar Fernandez, Flachenecker, Peter, Florin, Jack, Forrestal, Fiona, Frederiksen, Jette, Freedman, Mark, Freedman, Mark S, Freedman, Steven, Frequin, Stephan, Fryze, Waldemar, Gairin, Xavier Montalban, Garcia-Merino, Antonio, Garwacki, Dennis, Goldman, Myla, Goldman, Myla D, Gran, Bruno, Grand'Maison, François, Grimaldi, Luigi, Gunnarsson, Martin, Hardiman, Orla, Harrison, Daniel, Harrower, Timothy, Hartung, Hans-Peter, Havrdová, Eva Kubala, Havrdová, Eva Kubala, Hernandez Perez, Miguel Angel, Herrman, Craig, Hertmanowska, Hanka, Ho, Pei-Ran, Hobart, Jeremy, Hohlfeld, Reinhard, Huang, Deren, Hupperts, Raymond, Ilkowski, Jan, Jacques, François, Javed, Adil, Jeffery, Douglas, Jeffery, Douglas, Kamin, Stephen, Kaminska, Anna, Kanovsky, Petr, Kant, Matthias, Kapoor, Raju, Kapoor, Raju, Karussis, Dimitrios, Katsamakis, George, Khabirov, Farit, Khatri, Bhupendra, Killestein, Joep, Klodowska-Duda, Gabriela, Krumbholz, Markus, Lallana, José Meca, Langer-Gould, Annette, Lapierre, Yves, Laplaud, David, Lassek, Christoph, Lebrun Frenay, Christine, Lee, Liesly, Lee, Martin, Lucas, Nisha, Lycke, Jan, Lynch, Sharon, Maciejowski, Maciej, Maeurer, Mathias, Mancardi, Giovanni Luigi, Martin, Claes, Massacesi, Luca, Mattison, Paul, Mattson, David, Mcguigan, Christopher, Meuth, Sven, Mikol, Dan, Miller, Aaron, Miller, Tamara, Miravalle, Augusto, Morra, Vincenzo Brescia, Morrow, Sarah, Moses, Harold, Motta, Ewa, Muley, Suraj, Napier, James, Nicholas, Richard, Nielsen, Allen, Nocentini, Ugo, Oreja-Guevara, Celia, Pachner, Andrew, Pandolfo, Massimo, Pardo, Gabriel, Pearson, Owen, Pelletier, Jean, Petersen, Thor, Picone, Maryann, Piehl, Fredrik, Podemski, Ryszard, Potemkowski, Andrzej, Rashid, Waqar, Ravnborg, Mads, Robertson, Derrick, Rog, David, Rog, Teresa, Roshanisefat, Homayoun, Royal, Walter, Saiz Hinarejos, Albert, Salvetti, Marco, Sarasoja, Taneli, Scarpini, Elio, Schrijver, Hans, Sellebjerg, Finn, Sellebjerg, Finn, Selmaj, Krzysztof, Sharrack, Basil, Sheppard, Christopher, Silber, Eli, Sivertseva, Stella, Sola, Patrizia, Steiner, Deborah, Stelmasiak, Zbigniew, Stepien, Adam, Stetkarova, Ivana, Sundstrom, Peter, Talabova, Marika, Tedeschi, Gioacchino, Thrower, Ben, Trojano, Maria, Turner, Ben, Tutaj, Andrzej, Twyman, Cary, Van Dijl, Ronald, van Munster, Erik, Van Wijmeersch, Bart, Vermersch, Patrick, Vukusi, Sandra, Waubant, Emmanuelle, Wendt, Jeanette, Williams, Anna, Woolmore, John, Yadav, Vijayshree, Yakupov, Eduard, Yeung, Michael, Young, Carolyn, Yu, Bei, Zabad, Rana, Zaborski, Jacek, Zaffaroni, Mauro, Zarelli, Greg, Ziemssen, Tjalf +189 morecore +3 more sourcesGlycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker
Molecular Oncology, EarlyView.Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala +18 morewiley +1 more sourceEffects of vildagliptin on ventricular function in patients with type 2 diabetes mellitus and heart failure: a randomized placebo-controlled trial [PDF]
, 2017 Objectives:
This study sought to examine the safety of the dipeptidyl peptidase-4 inhibitor, vildagliptin, in patients with heart failure and reduced ejection fraction.Bolli, Geremia B., Kothny, Wolfgang, Kozlovski, Plamen, Krum, Henry, Lewsey, James D., Lukashevich, Valentina, McMurray, John J.V., Ponikowski, Piotr +7 morecore +2 more sourcesIdentification of acute respiratory distress syndrome subphenotypes de novo using routine clinical data: a retrospective analysis of ARDS clinical trials
BMJ Open, 2022 Fernando G Zampieri, Ary Serpa Neto, Alexandre Biasi Cavalcanti, Abhijit Duggal, Rachel Kast, Emily Van Ark, Lucas Bulgarelli, Matthew T Siuba, Jeff Osborn, Diego Ariel Rey, Israel Maia, Denise M Paisani, Ligia N Laranjeira, Rodrigo Octávio Deliberato +13 moredoaj +1 more sourceCDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane +12 morewiley +1 more source
