Results 131 to 140 of about 9,396,775 (321)

Adaptive Survival Trials [PDF]

, 2014
Mid-study design modifications are becoming increasingly accepted in confirmatory clinical trials, so long as appropriate methods are applied such that error rates are controlled.
Jaki, Thomas, Koenig, Franz, Magirr, Dominic, Posch, Martin   +3 more
core  

Efficient estimation of the distribution of time to composite endpoint when some endpoints are only partially observed.

, 2013
Two common features of clinical trials, and other longitudinal studies, are (1) a primary interest in composite endpoints, and (2) the problem of subjects withdrawing prematurely from the study. In some settings, withdrawal may only affect observation of
Daniel, Rhian M, Tsiatis, Anastasios A
core   +1 more source

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

Adverse Effects of a Clinically Relevant Dose of Hydroxyurea Used for the Treatment of Sickle Cell Disease on Male Fertility Endpoints [PDF]

, 2009
Kea M. Jones, Mohammad S. Niaz, Cynthia M. Brooks, Shannon Roberson, Maria P. Aguinaga, Edward R. Hills, Valerie Montgomery Rice, Phillip Bourne, Donald F. Bruce, Anthony E. Archibong   +9 more
openalex   +1 more source

Antibiofilm activity of a chionodracine‐derived peptide by NMR‐based metabolomics of cell‐free supernatant of Acinetobacter baumannii clinical strains

FEBS Open Bio, EarlyView.
KHS‐Cnd peptide is able to impair biofilm formation and disaggregate mature biofilms in Acinetobacter baumannii clinical isolates. Differences in extracellular metabolites reflect changes in biofilm metabolism due to KHS‐Cnd treatment. Among the differentially represented extracellular metabolites upon KHS‐Cnd treatment, the significantly altered ...
Fernando Porcelli, Enrico Landi, Francesco Maiurano, Irene Paris, Rosanna Papa, Marco Artini, Laura Selan, Stefano Borocci, Francesco Buonocore, Esther Imperlini   +9 more
wiley   +1 more source

Trends and Progress in Neuroendovascular Treatment in Japan: Japanese Registry of Neuroendovascular Therapy (JR-NET) 4. Main Report

Neurologia Medico-Chirurgica
We reported the main results of the Japanese Registry of Neuroendovascular Therapy (JR-NET) 4, a nationwide surveillance of therapy (NET) in Japan from January 2015 to December 2019.
Nobuyuki SAKAI, Satoru FUJIWARA, Kazutaka UCHIDA, Koji IIHARA, Hirotoshi IMAMURA, Akira ISHII, Yuji MATSUMARU, Chiaki SAKAI, Tetsu SATOW, Shinichi YOSHIMURA, Yasushi MATSUMOTO, Hidenori OISHI, Naoto KIMURA, Masayuki EZURA, Tatsufumi NOMURA, Shinzo OTA, Akio HYODO, Fuminori SHIMIZU, Japanese Registry of Neuroendovascular Therapy (JR-NET) Investigators   +18 more
doaj   +1 more source

Evaluating Magnetic Resonance Imaging and Serum Markers As Surrogate Endpoints for Clinical Trials in Cerebral Small Vessel Disease

, 2021
Marco Egle
openalex   +2 more sources

Proposed Definitions of T Cell-Mediated Rejection and Tubulointerstitial Inflammation as Clinical Trial Endpoints in Kidney Transplantation [PDF]

, 2022
Daniel Serón, Marion Rabant, Jan U. Becker, Candice Roufosse, Maria Irene Bellini, Georg A. Böhmig, Klemens Budde, Fritz Diekmann, Denis Glotz, Luuk B. Hilbrands, Alexandre Loupy, Rainer Oberbauer, Liset Pengel, Stefan Schneeberger, Maarten Naesens   +14 more
openalex   +1 more source

Clinical Endpoint

Definitions, 2020

semanticscholar   +1 more source

Protein Tyrosine Phosphatase 4A1 (PTP4A1) Regulates Early Events in Colorectal Cancer Intraperitoneal Dissemination in the Aged Male Host

Aging and Cancer, EarlyView.
Colorectal cancer (CRC) mortality is highest in aged males. Pre‐clinical data comparing CRC i.p. metastasis in cohorts of young and aged, male and female mice support these finding. Bottom‐up proteomics of peritoneal mesothelial cells identified PTP4A1 as highly expressed in aged males and a role for PTP4A1 in heterotypic cell:cell adhesion was ...
Zhikun Wang, Yueying Liu, Jing Yang, Tyvette S. Hilliard, Reihaneh Safavi‐Sohi, Daniel D. Hu, Elizabeth I. Harper, Gena Dominique, Wanrui Wang, Jeffrey Johnson, Marwa Asem, William Milosevich, Julia Florek Carlson, Yunpeng Bai, Jinmin Miao, Zhong‐Yin Zhang, Matthew M. Champion, M. Sharon Stack   +17 more
wiley   +1 more source