Results 231 to 240 of about 9,396,775 (321)
Reconfigurable Nucleic Acid Nanoparticles with Therapeutic RNAi Responses to Intracellular Disease Markers
Advanced Functional Materials, EarlyView.Many known diseases arise from dysregulated gene expression, and differentially expressed genes can serve as biomarkers to distinguish diseased cells from healthy tissues. In this study, reconfigurable nucleic acid nanoparticles (recNANPs) are introduced that can detect overexpressed cancer biomarkers and subsequently release RNAi inducers to silence ...Yelixza I. Avila, Anh Ha, Morgan R. Chandler, Nathalia Leal Santos, Taejin Kim, Hannah S. Newton, Marina A. Dobrovolskaia, Kirill A. Afonin +7 morewiley +1 more sourceProgression-free survival as a clinical trial endpoint in advanced renal cell carcinoma
, 2011 Sebastien J. Hotté, Georg A. Bjarnason, D.Y.C. Heng, M.A.S. Jewett, Anil Kapoor, Christian Kollmannsberger, Jean A. Maroun, Linda A. Mayhew, Scott North, M. Neil Reaume, Joseph D. Ruether, Denis Soulières, Peter Venner, Eric Winquist, Lori Wood, Jin-Young Yong, Fred Saad +16 moreopenalex +1 more source2014 ACC/AHA Key Data Elements and Definitions for Cardiovascular Endpoint Events in Clinical Trials: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Data Standards (Writing Committee to Develop Cardiovascular Endpoints Data Standards).
Circulation, 2015 K. Hicks, J. Tcheng, B. Bozkurt, B. Chaitman, D. Cutlip, A. Farb, G. Fonarow, J. Jacobs, M. Jaff, J. Lichtman, M. Limacher, K. Mahaffey, R. Mehran, S. Nissen, Eric E. Smith, S. Targum +15 moresemanticscholar +1 more sourcePrinting Nacre‐Mimetic MXene‐Based E‐Textile Devices for Sensing and Breathing‐Pattern Recognition Using Machine Learning
Advanced Functional Materials, EarlyView.This study presents a Ti3C2Tx MXene/WPU nacre‐mimetic nanomaterial as a printable ink for direct‐write printing onto textiles‐based sensors. The resulting wearable device demonstrates high sensitivity, biocompatibility, and mechanical strength. Furthermore, NFC‐enabled humidity sensor produces time‐series data, which informs a machine learning ...Lulu Xu, Wenqing Chen, Qian Li, Rohit Gupta, Biswajoy Bagchi, Laurence B. Lovat, Manish K. Tiwari +6 morewiley +1 more sourceSystemic and Tumor-directed Therapy for Oligorecurrent Metastatic Prostate Cancer (SATURN): Primary Endpoint Results from a Phase 2 Clinical Trial
John Nikitas, Matthew B. Rettig, John Shen, Robert E. Reiter, Alan Lee, Michael L. Steinberg, Luca Valle, Ankush Sachdeva, Tahmineh Romero, Jérémie Calais, Johannes Czernin, Nicholas G. Nickols, Amar U. Kishan +12 moreopenalex +2 more sourcesBiomaterial Strategies for Targeted Intracellular Delivery to Phagocytes
Advanced Functional Materials, EarlyView.Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...Kaitlyn E. Woodworth, Neal I. Callaghan, Locke Davenport Huyer +2 morewiley +1 more sourceBio‐Responsive Hydrogel for Targeted on‐Demand Release of a Phage Cocktail for Treatment of Pseudomonas aeruginosa Infection
Advanced Functional Materials, EarlyView.This study presents an injectable hydrogel that responds to Pseudomonas aeruginosa infection by releasing a dual‐phage cocktail on demand. The system degrades selectively in infected wounds, enhances phage localization and stability, and shows potent antibiofilm activity and biocompatibility in an ex vivo human skin model—offering a promising strategy ...Siyuan Tao, Anna Hu, Elnaz Bavel, Chien‐Hsun Yu, Sixuan Zhang, Vera Maria Kissling, Zhihao Li, Thomas Fintan Moriaty, Katharina Maniura‐Weber, Qun Ren +9 morewiley +1 more sourceDefining Endpoints and Biomarkers in Inflammatory Bowel Disease: Moving the Needle Through Clinical Trial Design
, 2020 María T. Abreu, William J. Sandborn, Fabio Cataldi, Geert D’Haens, Brian G. Feagan, Stephen B. Hanauer, Vipul Jairath, Péter L. Lakatos, Christopher Leptak, Dermot McGovern, Andrew E. Mulberg, Julián Panés, Asit Parikh, Laurent Peyrin‐Biroulet, Walter Reinisch, Robert H. Riddell, David T. Rubin, Bruce E. Sands, Johannes Spleiss, Richard Strauss, Swati Tole, Juli Tomaino +21 moreopenalex +1 more source
