Results 21 to 30 of about 9,396,775 (321)

Selecting the primary endpoint in a randomized clinical trial: the ARE method [PDF]

open access: yes, 2016
The decision on the primary endpoint in a randomized clinical trial is of paramount importance and the combination of several endpoints might be a reasonable choice. Gómez and Lagakos (2013) have developed a method that quantifies how much more efficient
Gómez Melis, Guadalupe   +1 more
core   +2 more sources

Evaluation of pathological complete response as surrogate endpoint in neoadjuvant randomised clinical trials of early stage breast cancer: systematic review and meta-analysis

open access: yesBritish medical journal, 2021
Objective To evaluate pathological complete response as a surrogate endpoint for disease-free survival and overall survival in regulatory neoadjuvant trials of early stage breast cancer. Design Systematic review and meta-analysis.
F. Conforti   +13 more
semanticscholar   +1 more source

Searching for potential surrogate endpoints of overall survival in clinical trials for patients with prostate cancer

open access: yesCancer Reports, 2021
Background The purpose of this study was to investigate the correlation between overall survival (OS) and other clinical outcomes in patients with prostate cancer. Further, we conducted subgroup analysis in the correlation of OS.
Hideki Maeda   +3 more
doaj   +1 more source

Complexity of design in early phase respiratory clinical trials; evaluating impact of primary endpoints and sponsor size

open access: yesContemporary Clinical Trials Communications, 2021
Asthma and COPD represent most of the clinical trials in the respiratory area. The Primary Endpoint (PE) defines how trials are conducted. We hypothesised that small and mid-sized pharmaceutical companies may be innovative in the selection of their trial
Nicolas Marco-Ariño   +3 more
doaj   +1 more source

An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics [PDF]

open access: yes, 2018
For a decade, The Cancer Genome Atlas (TCGA) program collected clinicopathologic annotation data along with multi-platform molecular profiles of more than 11,000 human tumors across 33 different cancer types.
A. Abeshouse   +740 more
core   +2 more sources

Clinical Perspectives and Trends: Microperimetry as a Trial Endpoint in Retinal Disease

open access: yesOphthalmologica, 2021
Endpoint development trials are underway across the spectrum of retinal disease. New validated endpoints are urgently required for the assessment of emerging gene therapies and in preparation for the arrival of novel therapeutics targeting the early ...
Yesa Yang, H. Dunbar
semanticscholar   +1 more source

Design of a real-world, prospective, longitudinal, observational study to compare vortioxetine with other standard of care antidepressant treatments in patients with major depressive disorder: a PatientsLikeMe survey

open access: yesBMC Psychiatry, 2023
Background Major depressive disorder (MDD) is a recurrent psychiatric condition that presents challenges in responding to treatment and achieving long-term remission.
Subhara Raveendran   +11 more
doaj   +1 more source

Neuroimaging as a selection tool and endpoint in preclinical and clinical trials [PDF]

open access: yes, 2016
Standard imaging in acute stroke enables the exclusion of non-stroke structural CNS lesions and cerebral haemorrhage from clinical and pre-clinical ischaemic stroke trials. In this review, the potential benefit of imaging (e.g., angiography and penumbral
Macrae, I. Mhairi, Muir, Keith W.
core   +2 more sources

Psychometric validation of the Dysphagia Symptom Questionnaire in patients with eosinophilic esophagitis treated with budesonide oral suspension

open access: yesJournal of Patient-Reported Outcomes, 2017
Background Eosinophilic esophagitis (EoE) is characterized by high levels of eosinophils in the esophageal mucosa. Patients with the disease present with a range of symptoms, including dysphagia (difficulty swallowing).
Stacie Hudgens   +3 more
doaj   +1 more source

Frontal two-electrode transcranial direct current stimulation protocols may not affect performance on a combined flanker Go/No-Go task

open access: yesScientific Reports, 2023
Transcranial direct current stimulation (tDCS) has been tested to modulate cognitive control or response inhibition using various electrode montages. However, electrode montages and current polarities have not been systematically compared when examining ...
Adrienn Holczer   +3 more
doaj   +1 more source

Home - About - Disclaimer - Privacy