Results 41 to 50 of about 9,396,775 (321)

Characteristics of ADHD symptom response/remission in a clinical trial of methylphenidate extended release [PDF]

, 2019
Clinical trials in attention-deficit/hyperactivity disorder (ADHD) have typically measured outcome using clinician ratings on the Attention-Deficit/Hyperactivity Disorder Rating Scale, Fourth Edition (ADHD-RS-IV) and the Clinical Global Impression ...
Adjei, Akwete L, Childress, Ann, Kupper, Robert J, Mattingly, Greg, Nordbrock, Earl, Weiss, Margaret   +5 more
core   +2 more sources

Adjunctive therapies to reduce thrombotic events in patients with a history of myocardial infarction : role of vorapaxar [PDF]

, 2015
© 2015 Farag et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) LicenseAcute myocardial infarction (AMI) is generally attributed to coronary atherothrombotic ...
Farag, Mohamed, Gorog, Diana A, Patel, Hiten   +2 more
core   +3 more sources

Evaluating futility of a binary clinical endpoint using early read‐outs

Statistics in Medicine, 2019
Interim analyses are routinely used to monitor accumulating data in clinical trials. When the objective of the interim analysis is to stop the trial if the trial is deemed futile, it must ideally be conducted as early as possible.
K. Van Lancker, A. Vandebosch, S. Vansteelandt, F. De Ridder   +3 more
semanticscholar   +1 more source

Selenium-Binding Protein 1 Indicates Myocardial Stress and Risk for Adverse Outcome in Cardiac Surgery [PDF]

, 2019
Selenium-binding protein 1 (SELENBP1) is an intracellular protein that has been detected in the circulation in response to myocardial infarction. Hypoxia and cardiac surgery affect selenoprotein expression and selenium (Se) status.
Kühn, Eike C., Kühn-Heid, Ellen C. D., Minich, Waldemar B., Ney, Julia, Schomburg, Lutz, Schwiebert, Christian, Seelig, Julian, Stoppe, Christian, Wendt, Sebastian   +8 more
core   +1 more source

Usefulness of EQ-5D in Assessing Health Status in Primary Care Patients with Major Depressive Disorder [PDF]

, 2004
Objectives Major depressive disorder (MDD) is a prevalent psychiatric disorder associated with impaired patient functioning and reductions in health-related quality of life (HRQL).
Bruno Fantino, Christophe Sapin, Marie-Laure Nowicki, Paul Kind, Sapin, Christophe   +4 more
core   +3 more sources

A qualitative investigation of the Montgomery–Åsberg depression rating scale: discrepancies in rater perceptions and data trends in remote assessments of rapid-acting antidepressants in treatment resistant depression

Frontiers in Psychiatry
IntroductionDespite the development of many successful pharmaceutical interventions, a significant subset of patients experience treatment-resistant depression (TRD).
Gianna Capodilupo, Raymond Blattner, Raymond Blattner, Anita Must, Anita Must, Silvia Gamazo Navarro, Silvia Gamazo Navarro, Mark Opler, Mark Opler   +8 more
doaj   +1 more source

Clinical study protocol for a low-interventional study in intermediate age-related macular degeneration developing novel clinical endpoints for interventional clinical trials with a regulatory and patient access intention—MACUSTAR

Trials, 2020
Background There is an unmet need for treatment options in intermediate age-related macular degeneration (iAMD). However, for any new interventions to be tested in clinical trials, novel currently unavailable clinical endpoints need to be developed. Thus,
Jan H. Terheyden, Frank G. Holz, Steffen Schmitz-Valckenberg, Anna Lüning, Matthias Schmid, Gary S. Rubin, Hannah Dunbar, Adnan Tufail, David P. Crabb, Alison Binns, Clara I. Sánchez, Carel Hoyng, Philippe Margaron, Nadia Zakaria, Mary Durbin, Ulrich Luhmann, Parisa Zamiri, José Cunha-Vaz, Cecília Martinho, Sergio Leal, Robert P. Finger, on behalf of the MACUSTAR consortium   +21 more
doaj   +1 more source

Rifampicin and clarithromycin (extended release) versus rifampicin and streptomycin for limited Buruli ulcer lesions: a randomised, open-label, non-inferiority phase 3 trial. [PDF]

, 2020
BACKGROUND: Buruli ulcer is a neglected tropical disease caused by Mycobacterium ulcerans infection that damages the skin and subcutis. It is most prevalent in western and central Africa and Australia.
Abass, KM, Agossadou, D, Ampadu, EO, Asiedu, KB, Chauty, A, Egondi, TW, Frimpong, M, Ganlonon, L, Gateau, T, Grosset, J, Lehman, L, Macdonald, JM, Marion, E, Ochieng Otieno, M, Ohene, S-A, Omollo, R, Paintsil, A, Phillips, RO, Robert, J, Saizonou, R, Sarfo, FS, Sarpong, G, Sarpong, NF, Saunderson, P, Stienstra, Y, study team, Thompson, W, Tiendrebeogo, A, Treadwell, T, van der Werf, TS, Wansbrough-Jones, M, Wilson, T   +31 more
core   +3 more sources

EVIDENCE meta-analysis: evaluating minimal residual disease as an intermediate clinical endpoint for multiple myeloma.

Blood
Estimating progression-free survival (PFS) and overall survival (OS) superiority during clinical trials of multiple myeloma (MM) has become increasingly challenging as novel therapeutics have improved patient outcomes.
O. Landgren, Thomas J. Prior, T. Masterson, Christoph Heuck, Orlando F Bueno, Ajeeta B. Dash, H. Einsele, H. Goldschmidt, Stefan Knop, Cong Li, U. Mellqvist, Ian McFadden, Corina Oprea, Jeremy A. Ross, Mihaela Talpes, Jay Hydren, Jenny Ahlstrom, D. Kazandjian, Niels Weinhold, Rick Zhang, M. Stetler-Stevenson, Gerald E. Marti, Sean M. Devlin   +22 more
semanticscholar   +1 more source

Longitudinal Analysis of Quality of Life, Clinical, Radiographic, Echocardiographic, and Laboratory Variables in Dogs with Preclinical Myxomatous Mitral Valve Disease Receiving Pimobendan or Placebo: The EPIC Study [PDF]

, 2018
Background: Changes in clinical variables associated with the administration of pimobendan to dogs with preclinical myxomatous mitral valve disease (MMVD) and cardiomegaly have not been described. Objectives: To investigate the effect of pimobendan on
Abbott, J A, Barrett, K A, Bomassi, E, Bonagura, J D, Boswood, A, Church, W M, Deinert, M, Estrada, A H, Fernández-Del Palacio, M J, Fox, P R, Fujii, Y, Gordon, S G, Häggström, J, Jaudon, J P, Keene, B W, Kresken, J-G, Ljungvall, I, Luethy, M W, MacDonald, K A, Menaut, P, Moise, N S, O'Sullivan, M L, Oyama, M A, Patteson, M, Rosenthal, S L, Rush, J, Sanderson, K, Santilli, R A, Saunders, A B, Schummer, C, Smith, S, Spier, A, Stepien, R L, Szatmári, V, Tidholm, A, Uechi, M, Watson, P, Wess, G, Woolley, R   +38 more
core   +7 more sources