Results 51 to 60 of about 9,396,775 (321)

A comparison of methods for treatment selection in seamless phase II/III clinical trials incorporating information on short-term endpoints [PDF]

, 2015
In an adaptive seamless phase II/III clinical trial interim analysis data are used for treatment selection, enabling resources to be focussed on comparison of more effective treatment(s) with a control.
Friede, Tim, Kunz, Cornelia, Parsons, Nicholas R., Stallard, Nigel, Todd, Susan   +4 more
core   +1 more source

Interferon β-1a in relapsing multiple sclerosis: four-year extension of the European IFNβ-1a Dose-C omparison Study [PDF]

, 2004
Background: Multiple sclerosis (MS) is a chronic disease requiring long-term monitoring of treatment. Objective: To assess the four-year clinical efficacy of intramuscular (IM) IFNb-1a in patients with relapsing MS from the European IFNb-1a Dose-C ...
Achiti, J., Arbizu, T., Arnulf, I., Aubertin, P., Bamborschke, P., Belliard, S., Berger, E., Blanc, S., Brassat, D., Brochet, B., Cahagne, V., Casado, A., Cesaro, P., Chan, A., Clanet, M., Confavreux, C., Dalecky, A., Damier, P., de Keyser, Jacques, de Marco, A., Defer, G., Degos, F., Dengler, R., Dose, A., Edan, G., Engles, A., Fernandez, O., Flachenecker, A., Gayou, A., Gelderblom, H., Grunwald, F., Grupe, A., Hartung, H.P., Heesen, C., Heidenreich, F., Heinzlef, O., Hohlfeld, R., Kappos, L., Kassim, N., Koehler, A., Koerner, A., Kristoferitsch, W., Kunze, K., Kyriallis, K., Lau, G., Lecanuet, P., Lindert, A., Liu, A., Lubetzki, C., Luenemann, J., Lyon-Caen, O., Magnier, C., Martin, A, Martinez-Yelamos, A., Matzke, A., Maurer, A., Mekies, C., Menck, A., Montalban, X., Moulin, A., Nolden, A., Nos, A., Pantzaris, A., Papacostas, S., Pelletier, J., Petereit, H., Pez, D., Piette, A., Riche, G., Rieckmann, P., Romero, F., Rouanet, M., Rouant, F., Roullet, E., Rumbach, L., Sailer, 27449, Schaeffer, S., Schlederer, A., Schrieber, A., Seeldrayers, P., Senard, A., Stankoff, B., Steiner, A., Stingle, A., Storch-Hagenlocher, A., Storch-Hagenlocher, B., Suchet, L., Tamayo, J.A., Tamman, D., Thalamas, C., Vermersch, P., Vogt-Schaden, A., Vuilleman, C., Weilbach, A., Weiler, C., Windhagen, A., Zorgdrager, A., Zschenderlein, R., Zwanniken, G.   +98 more
core   +1 more source

Assessment of severe malaria in a multicenter, phase III, RTS, S/AS01 malaria candidate vaccine trial: case definition, standardization of data collection and patient care. [PDF]

, 2011
BACKGROUND\ud \ud An effective malaria vaccine, deployed in conjunction with other malaria interventions, is likely to substantially reduce the malaria burden. Efficacy against severe malaria will be a key driver for decisions on implementation.
Amanda Leach, Brian Greenwood, Daniel Ansong, David Schellenberg, Jahit Sacarlal, Jennifer Evans, Johan Vekemans, Kevin Marsh, Kwaku Asante, Mary J Hamel, Nahya Salim, null null, Patricia Njuguna, Philip Bejon, Portia Kamthunzi, Samwel Gesase, Solange Soulanoudjingar, Walter Otieno, William Kabore   +18 more
core   +4 more sources

Automatic Urticaria Activity Score: Deep Learning–Based Automatic Hive Counting for Urticaria Severity Assessment

JID Innovations
Chronic urticaria is a chronic skin disease that affects up to 1% of the general population worldwide, with chronic spontaneous urticaria accounting for more than two-thirds of all chronic urticaria cases.
Taig Mac Carthy, Ignacio Hernández Montilla, Andy Aguilar, Rubén García Castro, Ana María González Pérez, Alejandro Vilas Sueiro, Laura Vergara de la Campa, Fernando Alfageme, Alfonso Medela   +8 more
doaj   +1 more source

Cross‐sectional and longitudinal assessments of function in prodromal‐to‐mild Alzheimer's disease: A comparison of the ADCS‐ADL and A‐IADL‐Q scales

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2023
Introduction Prior observational work in a heterogeneous cohort of participants with mild cognitive impairment suggests the Amsterdam Instrumental Activities of Daily Living Questionnaire (A‐IADL‐Q) may have greater sensitivity for functional decline ...
Edmond Teng, Yihao Li, Paul T. Manser, Karen Pickthorn, Brandon D. Butcher, Mira Blendstrup, Christopher Randolph, Sietske A.M. Sikkes   +7 more
doaj   +1 more source

Effect of sacubitril/valsartan on recurrent events in the prospective comparison of ARNI with ACEI to determine impact on global mortality and morbidity in heart failure trial (PARADIGM-HF) [PDF]

, 2018
Aims: Recurrent hospitalizations are a major part of the disease burden in heart failure (HF), but conventional analyses consider only the first event. We compared the effect of sacubitril/valsartan vs.
Abraham, Andersen, Anker, Anker, Borer, Ghosh, Greenberg, Lin, McMurray, McMurray, Metcalfe, Neaton, Packer, Rogers, Rogers, Rogers, Rogers, Solomon, Wei   +18 more
core   +3 more sources

The Alzheimer’s Prevention Initiative Composite Cognitive Test: a practical measure for tracking cognitive decline in preclinical Alzheimer’s disease

Alzheimer’s Research & Therapy, 2020
Background There is growing interest in identifying sensitive composite cognitive tests to serve as primary endpoints in preclinical Alzheimer’s disease (AD) treatment trials.
Jessica B. Langbaum, Noel N. Ellison, Angelika Caputo, Ronald G. Thomas, Carolyn Langlois, Marie-Emmanuelle Riviere, Ana Graf, Cristina Lopez Lopez, Eric M. Reiman, Pierre N. Tariot, Suzanne B. Hendrix   +10 more
doaj   +1 more source

RAD50 missense variants differentially affect the DNA damage response and mitotic progression

FEBS Letters, EarlyView.
RAD50 incorporates into the MRN complex and initiates the DNA damage response. Furthermore, RAD50 promotes mitotic progression. RAD50 missense variants capable of forming an MRN complex supported the DNA damage response and mitotic features to different extents in complementation experiments, indicating these functions are separable and might impact ...
Hanna Redeker, Swantje Kebel, Lea Völkening, Anna Vatselia, Louisa Weinhold, Girmay Asgedom, Axel Schambach, Detlev Schindler, Thilo Dörk, Kristine Bousset   +9 more
wiley   +1 more source

Extension of the asymptotic relative efficiency method to select the primary endpoint in a randomized clinical trial [PDF]

, 2014
We extend the ARE method proposed in Gómez and Lagakos (2013) devised to decide which primary endpoint to choose when comparing two treatments in a randomized clinical trial.
Gómez Melis, Guadalupe, Plana-Ripoll, Oleguer   +1 more
core  

Randomized trial comparing proactive, high-dose versus reactive, low-dose intravenous iron supplementation in hemodialysis (PIVOTAL) : Study design and baseline data [PDF]

, 2018
Background: Intravenous (IV) iron supplementation is a standard maintenance treatment for hemodialysis (HD) patients, but the optimum dosing regimen is unknown.
Anker, Stefan D., Bhandari, Sunil, Farrington, Kenneth, Ford, Ian, Kalra, Philip A., Macdougall, Iain C., McMurray, John J.V., Murray, Heather, Steenkamp, Retha, Tomson, Charles R.V., Wheeler, David C., White, Claire, Winearls, Christopher G.   +12 more
core   +4 more sources