Results 21 to 30 of about 501,910 (264)

Development and clinical evaluation of a supramolecular acid-enzyme complex for skin exfoliation, sebum control, and pore refinement

Journal of Dermatologic Science and Cosmetic Technology
Background: Enzyme fragility remains a major challenge in research and applications. Free enzymes are highly unstable, inactivated by heat, acid, alkali, or organic solvents, and often lose activity even under optimal storage conditions.
Huwu Zhou, Wenrong Zhang, Xuewan Li, Rongrong Li, Changzhi Dong, Lifeng Tang   +5 more
doaj   +1 more source

Gaucher's disease in children: Case report from Afghanistan with literature review

Global Pediatrics, 2023
Introduction and importance: Gaucher's disease (GD) or lysosomal storage disease, is one of the rare genetic disorders resulting from glucocerebrosidase deficiency.
Turyalai Hakimi, Omran Omar Amarkhil, Muhammad Arif Zamani, Mansoor Aslamzai, Salmai Turial, Mohammad Tareq Rahimi, Mohammad Anwar Jawed   +6 more
doaj   +1 more source

Optimization and purification of L-methioninase enzyme purified from clinical samples of Pseudomonas spp.

مجلة مركز بحوث التقنيات الاحيائية
Background: This study focused on Pseudomonas aeruginosa, which secrete important enzymes in medical and pharmaceutical applications and are isolated from clinical samples. One of these enzymes is L-methioninase, the most desirable enzyme in the medical
Aya S. Aldawood, Ruqaya M. Al-ezzy
doaj   +1 more source

Adjunctive Therapeutic Plasma Exchange in Refractory Adult‐Onset Still's Disease Complicated by Secondary Macrophage Activation Syndrome: A Single‐Center Experience

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Adult‐onset Still's disease (AOSD) complicated by macrophage activation syndrome (MAS) carries substantial mortality. The role of therapeutic plasma exchange (TPE) remains uncertain. Methods We retrospectively analyzed patients with AOSD‐MAS treated with TPE at a single‐center.
Masataka Ueda, Tomohiro Saito, Masahide Mizobuchi, Tomoki Shimomura, Saki Kawamori, Mitsuru Kawanishi, Natsuko Hattori, Jo Sugiyama, Satoshi Tsubata, Hanami Horiguchi, Kazuki Abe, Nao Iida, Yuki Kajio, Nao Oguro, Ryo Yanai, Hirokazu Honda   +15 more
wiley   +1 more source

Lysosomal diseases: Overview on current diagnosis and treatment

Genetics and Molecular Biology, 2019
Lysosomal diseases (LDs), also known as lysosomal storage diseases (LSDs), are a heterogeneous group of conditions caused by defects in lysosomal function.
Fabiano de Oliveira Poswar, Filippo Vairo, Maira Burin, Kristiane Michelin-Tirelli, Ana Carolina Brusius-Facchin, Francyne Kubaski, Carolina Fischinger Moura de Souza, Guilherme Baldo, Roberto Giugliani   +8 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Gaucher Disease - From Textbook Obscurity to Clinical Reality: A Case Report with Diagnostic and Therapeutic Implications at Moi Teaching and Referral Hospital

Case Reports in Clinical Practice
Gaucher’s disease is a rare lysosomal storage disorder caused by a deficiency of the enzyme β-glucocerebrosidase, leading to progressive accumulation of glucocerebroside within macrophages.
Isaac Osore Ogola, Alice Gichemi, Maureen Mumbua Kiio, Wendy Matendechele, Gilbert Olbara, Festus Muigai   +5 more
doaj   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Advanced diagnostic techniques in autoimmune bullous diseases

Indian Journal of Dermatology, 2017
Autoimmune blistering diseases are diverse group of conditions characterized by blisters in the skin with or without mucosal lesions. There may be great degree of clinical and histopathological overlap; hence, advanced immunological tests may be ...
Anuradha Jindal, Raghavendra Rao, Balbir S Bhogal   +2 more
doaj   +1 more source