Results 191 to 200 of about 5,841,868 (306)

Impairments in biological motion perception reflect affective disturbance in individuals at clinical high-risk for psychosis. [PDF]

Schizophr Res Cogn
Parmacek SN, Pratt DN, Mittal VA.
europepmc   +1 more source

Enhanced telepresence for clinical training in high‐risk environments

Medical Education, 2020
Salcedo, Daniel, Huang, Wen‐Cheng, Suk, Fat‐Moon, Lin, Che‐Wei   +3 more
openaire   +2 more sources

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Treatment Choices for Youth at Clinical High-Risk of Psychosis: Methods of an Open Trial. [PDF]

Early Interv Psychiatry
Addington J, Liu L, Braun A, Jahraus C, Brummitt K, Stowkowy J.   +5 more
europepmc   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Negative symptoms and self-reflection increase alienation in individuals at clinical high-risk for psychosis. [PDF]

Front Psychiatry
Mendonça M, Haddad NM, de Jesus LP, Andrade JC, Fekih-Romdhane F, Serpa MH, van de Bilt MT, Gattaz WF, Rössler W, Loch AA.   +9 more
europepmc   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

A meta-analysis comparing cognitive function between individuals at clinical high-risk for psychosis and individuals at family high-risk for psychosis. [PDF]

BMC Psychiatry
Gao R, Fan M, Wei A, Liu T, Guo L, He X, Liu Z.   +6 more
europepmc   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Disrupted physiological coregulation in youth at clinical high risk for psychosis: Insights from a dyadic interaction study. [PDF]

Emotion
Schreiber AM, Martinez M, Li S, Williams TF, Alexander N, Mittal VA, Haase CM.   +6 more
europepmc   +1 more source