Results 141 to 150 of about 9,220,792 (417)

A potential tumor suppressor role of PLK2 in glioblastoma

FEBS Open Bio, EarlyView.
PLK2 was consistently downregulated in GBM tissues. Overexpression of PLK2 in GBM cell lines U87MG and U251 reduced their tumorigenic potential and enhanced cell cycle arrest and apoptosis. Suggesting that PLK2 overexpression could potentially be leveraged as a therapeutic strategy to inhibit tumor progression and enhance apoptosis, providing new ...
Xiangping Xia, Peirui Wang, Hua Xiao, Qishan Ran, Yan Li, Shengtao Yao   +5 more
wiley   +1 more source

Virus-like particle vaccines: immunology and formulation for clinical translation

Expert Review of Vaccines, 2018
Introduction: Virus-like particle (VLP) vaccines face significant challenges in their translation from laboratory models, to routine clinical administration. While some VLP vaccines thrive and are readily adopted into the vaccination schedule, others are
Braeden Donaldson, Zabeen Lateef, G. Walker, S. Young, V. Ward   +4 more
semanticscholar   +1 more source

Understanding and Overcoming Immunotherapy Resistance in Skin Cancer: Mechanisms and Strategies

Aging and Cancer, EarlyView.
This narrative review explores the mechanisms driving immunotherapy resistance in skin cancer, including tumor microenvironment factors, genetic mutations, and immune evasion strategies. It highlights potential strategies to overcome resistance, offering insights for improving therapeutic outcomes and guiding future research in personalized ...
Shreya Singh Beniwal, Abhimanyu Chiraparambil Radhakrishnan, Ayanchetty Haripraba, Saif Syed, Gajawada Pragna, Ayush Dwivedi, Akash Rawat, Daniela Castro Calderón, Martin Cevallos‐Cueva   +8 more
wiley   +1 more source

Maximum Matchings in Graphs for Allocating Kidney Paired Donation [PDF]

arXiv, 2017
Relatives and friends of an end-stage renal disease patient who offer to donate a kidney are often found to be incompatible with their intended recipients. Kidney paired donation matches one patient and his incompatible donor with another patient and donor in the same situation for an organ exchange.
arxiv  

Human immunology studies using organ donors: Impact of clinical variations on immune parameters in tissues and circulation

American Journal of Transplantation, 2018
Organ donors are sources of physiologically healthy organs and tissues for life‐saving transplantation, and have been recently used for human immunology studies which are typically confined to the sampling of peripheral blood.
D. Carpenter, T. Granot, N. Matsuoka, T. Senda, B. V. Kumar, J. Thome, C. Gordon, M. Miron, J. Weiner, T. Connors, H. Lerner, A. Friedman, T. Kato, A. Griesemer, D. Farber   +14 more
semanticscholar   +1 more source

Analysis of the Characteristics of Patients Presenting with Exacerbation of Asthma to Emergency Care Units [PDF]

, 2015
Background:Fatal asthma remains a serious problem, and patient self-management of asthma is important to prevent exacerbation. To reduce the asthma mortality rate, we analyzed the characteristics of patients who visited an emergency care unit with ...
Department Of Pulmonary Medicine And Clinical Immunology Dokkyo Medical University:Department Of Pulmonary Medicine And Clinical Immunology Dokkyo Medical University, Department Of Respiratory Medicine, Dokkyo Medical University Koshigaya Hospital, Department Of Respiratory Medicine, Dokkyo Medical University Koshigaya Hospital:Department Of Pulmonary Medicine And Clinical Immunology Dokkyo Medical University, Department Of Respiratory Medicine, Dokkyo Medical University Koshigaya Hospital:Department Of Pulmonary Medicine And Clinical Immunology Dokkyo Medical University, Department Of Respiratory Medicine, Dokkyo Medical University Koshigaya Hospital:Department Of Pulmonary Medicine And Clinical Immunology Dokkyo Medical University, Department Of Respiratory Medicine, Dokkyo Medical University Koshigaya Hospital:Department Of Pulmonary Medicine And Clinical Immunology Dokkyo Medical University, Department Of Respiratory Medicine, Dokkyo Medical University Koshigaya Hospital:Department Of Pulmonary Medicine And Clinical Immunology Dokkyo Medical University, Department Of Respiratory Medicine, Dokkyo Medical University Koshigaya Hospital:Department Of Pulmonary Medicine And Clinical Immunology Dokkyo Medical University, Department Of Respiratory Medicine, Dokkyo Medical University Koshigaya Hospital:Department Of Pulmonary Medicine And Clinical Immunology Dokkyo Medical University, Hideyuki Satoh, Kentaro Nakano, Kumiya Sugiyama, Naruo Yoshida, Ryosuke Souma, Shingo Tokita, Takeshi Fukuda, Tomoshige Wakayama, Yasutsugu Fukushima   +17 more
core   +1 more source

Integrating Candida albicans metabolism with biofilm heterogeneity by transcriptome mapping [PDF]

, 2016
This work was supported by the Wellcome Trust Strategic Award for Medical Mycology and Fungal Immunology 097377/Z/11/Z. We are grateful to microbiology colleagues throughout Scotland for clinical isolates collection.Peer reviewedPublisher ...
Abeln, Sanne, Brandt, Bernd W., Burgess, Karl V, Heringa, Jaap, Jones, Brian L., Kean, Ryan, May, Ali, Munro, Carol A., Rajendran, Ranjith, Ramage, Gordon, Sherry, Leighann, Williams, Craig   +11 more
core   +4 more sources

Prediction and prevention of allergy and asthma in EAACI journals (2016)

Clinical and Translational Allergy, 2017
The European Academy of Allergy and Clinical Immunology (EAACI) owns three journals: Allergy, Pediatric Allergy and Immunology and Clinical and Translational Allergy.
Jean Bousquet, Clive Grattan, Thomas Bieber, Paolo Matricardi, Hans Uwe Simon, Ulrich Wahn, Antonella Muraro, Peter W. Hellings, Ioana Agache   +8 more
doaj   +1 more source

Modelling Immunological Memory [PDF]

In Silico Immunology, 83-108, 2006, 2010
Accurate immunological models offer the possibility of performing highthroughput experiments in silico that can predict, or at least suggest, in vivo phenomena. In this chapter, we compare various models of immunological memory. We first validate an experimental immunological simulator, developed by the authors, by simulating several theories of ...
arxiv  

How Clinical Flow Cytometry Rebooted Sepsis Immunology

Cytometry Part A, 2019
On May 2017, the World Health Organization (WHO) recognized sepsis as a global health priority by adopting a resolution to improve the prevention, diagnosis, and management of this deadly disease.
G. Monneret, M. Gossez, N. Aghaeepour, B. Gaudilliere, F. Venet   +4 more
semanticscholar   +1 more source