Results 71 to 80 of about 13,898 (207)

Dapagliflozin does not impair microvascular hemorheology in type 2 diabetes mellitus: A multicenter randomized controlled trial (D‐PATH study)

Journal of Diabetes Investigation, EarlyView.
Graphical abstract illustrating the study design, physiological rationale, and key findings of the D‐PATH trial. Dapagliflozin, an SGLT2 inhibitor, lowers HbA1c and body weight while increasing hematocrit and erythropoietin levels. Although an elevated hematocrit could theoretically increase blood viscosity and impair microcirculatory flow, ex vivo ...
Yuki Nakatani, Nobuyuki Banba, Shoya Ono, Tomoki Turumi, Megumi Hoshiai, Takushi Sugiyama, Takashi Tomoe, Hajime Tamiya, Naoyuki Otani, Hiroyuki Sugimura, Hidekazu Ikemiyagi, Yusuke Ohya, Koji Yokokawa, Shinichiro Ueda, Yoshimasa Aso, Yasuhiro Maejima, Takanori Yasu   +16 more
wiley   +1 more source

Lipolysis inhibition as a treatment of clinical ketosis in dairy cows: Effects on adipose tissue metabolic and immune responses

Journal of Dairy Science
: Dairy cows with clinical ketosis (CK) exhibit excessive adipose tissue (AT) lipolysis and systemic inflammation. Lipolysis in cows can be induced by the canonical (hormonally induced) and inflammatory lipolytic pathways.
Miguel Chirivi, Daniela Cortes, C. Javier Rendon, G. Andres Contreras   +3 more
doaj   +1 more source

Hemato-Biochemical Studies on Clinical Cases of Primary Ketosis in Buffaloes

Journal of Animal Research, 2015
The study was conducted on 145 buffaloes brought to Teaching Veterinary Clinical Complex, LUVAS from Hisar and adjoining villages, with signs of anorexia and decreased milk yield. Urine samples from buffaloes were screened for ketosis using two tests (Rothera's test and Keto-Diastix-strip test).
Ankit Kumar, Tarun Kumar, Parmod Kumar, Gaurav Charaya, Neelesh Sindhu, Sonu Kumari, Rajendra Yadav, null Sridhar   +7 more
openaire   +1 more source

Epileptic–Dyskinetic Encephalopathy Associated with a PPP3CA Variant: Expansion of the Phenotypic Spectrum

Movement Disorders Clinical Practice, EarlyView.
Bruno Antunes Contrucci, Ursula Thomé, Larissa Aparecida Batista, Ana Laura Volpi Martins Lorenzoni, Carla Andrea Cardoso Tanuri Caldas, Americo Ceiki Sakamoto, Israel Gomy, Lisandra Mesquita Batista, Marcela Lopes de Almeida, Ana Paula Andrade Hamad, Guillermo Andrey Ariza Traslaviña   +10 more
wiley   +1 more source

Dietary interventions in acute kidney injury: From molecular mechanism to clinical trials

Experimental Physiology, EarlyView.
Abstract Ageing impairs renal resilience with an elevated risk of frequent and harmful acute kidney injury (AKI) that causes substantial morbidity and mortality among hospitalized patients. Since different damaging stimuli at the molecular, cellular and functional level contribute to this loss in kidney function, AKI's pathophysiology is heterogeneous ...
Felix C. Koehler, Pedro Rojas‐Morales, Roman‐Ulrich Müller   +2 more
wiley   +1 more source

Multiple Carboxylase Deficiency in an Infant Presenting With Severe Metabolic Acidosis and Sepsis‐Like Features: A Case Report and Literature Review

Clinical Case Reports, Volume 14, Issue 7, July 2026.
ABSTRACT Multiple carboxylase deficiency (MCD) is a rare, treatable inborn error of biotin metabolism that may present in children in the first year of life with life‐threatening metabolic crises. We report a 4‐month‐old child presenting with persistent seizures, eczematous rash near the orifices, unjustified loss of hair with baldness, and severe ...
Touqeer Rehman, Riyan Saeed, Muhammad Ahmed Akif Rauf, Luqman Asif, Muhammad Junaid, Muddassir Khalid, Rao Nouman Ali, Umair Ali, Fred Segawa   +8 more
wiley   +1 more source

Cullin 3 mitigates nonesterified fatty acid–induced oxidative stress in mammary epithelial cells: Involvement of BCL2/BECN1 and autophagy

Journal of Dairy Science
: High nonesterified fatty acid (NEFA) concentrations in cows with clinical ketosis lead to metabolic dysfunction in mammary cells, resulting in oxidative stress.
Yifei Dong, Wenwen Gao, Kai Liu, Cai Lin, Muhammad Usman, Juan J. Loor, Guojin Li, Liguang Cao, Zifeng Yang, Jianchun Luo, Depeng Li, Qianwen Sun, Lin Lei, Xiliang Du, Yuxiang Song, Guowen Liu, Xinwei Li   +16 more
doaj   +1 more source

Non-carbohydrate anaplerotic therapy counters empagliflozin-induced diabetic ketosis

Nutrition & Diabetes
Background SGLT2 inhibitors (SGLTi) confer significant cardiometabolic benefits in diabetes, but are associated with increased risk of diabetic ketoacidosis (DKA).
Jimmy Asiku, Mugagga Kalyesubula, Maya Ross, Betty Schwartz, Alexander Rosov, Hay Dvir   +5 more
doaj   +1 more source

PHB2-mediated inhibition of OPA1 cleavage alleviates nonesterified fatty acid–induced apoptosis in bovine mammary epithelial cells

Journal of Dairy Science
: Excessive nonesterified fatty acids (NEFA) during the transition period impose metabolic stress on the bovine mammary gland. High NEFA levels induce oxidative stress and trigger apoptosis in bovine mammary epithelial cells.
Guojin Li, Qi Shao, Qingyan Yin, Kai Liu, Liguang Cao, Jianchun Luo, Depeng Li, Qianwen Sun, Lin Lei, Yuxiang Song, Xiliang Du, Xinwei Li, Guowen Liu, Wenwen Gao   +13 more
doaj   +1 more source

Comparative evaluation of cytokine and acute-phase protein concentrations in sera of dairy cows with subclinical and clinical ketosis as a different view of the causes of the disease. [PDF]

Vet World, 2021
Brodzki P, Marczuk J, Lisiecka U, Szczubiał M, Brodzki A, Gorzkoś H, Kulpa K.   +6 more
europepmc   +1 more source