Results 51 to 60 of about 1,465,486 (372)

Blood, sweat, and tears: developing clinically relevant protein biosensors for integrated body fluid analysis [PDF]

, 2015
Biosensors are being developed to provide rapid, quantitative, diagnostic information to clinicians in order to help guide patient treatment, without the need for centralised laboratory assays.
Coffey, J. W., Corrie, S. R., Islam, J., Kendall, M. A. F., Markey, K. A.   +4 more
core   +1 more source

Endogenous endophthalmitis caused by a multidrug-resistant hypervirulent Klebsiella pneumoniae strain belonging to a novel single locus variant of ST23: first case report in China

BMC Infectious Diseases, 2018
Background Endogenous endophthalmitis caused by hypervirulent Klebsiella pneumoniae (HVKP) is an emerging infectious disease commonly with a devastating visual outcome. Most HVKP strains display a wild-type susceptibility profile to antibiotics. However,
Min Xu, Ang Li, Haishen Kong, Weili Zhang, Hongchao Chen, Yajie Fu, Yiqi Fu   +6 more
doaj   +1 more source

Computer-Assisted Analysis of Biomedical Images [PDF]

arXiv, 2021
Nowadays, the amount of heterogeneous biomedical data is increasing more and more thanks to novel sensing techniques and high-throughput technologies. In reference to biomedical image analysis, the advances in image acquisition modalities and high-throughput imaging experiments are creating new challenges. This huge information ensemble could overwhelm
arxiv  

Uncertainty estimations methods for a deep learning model to aid in clinical decision-making -- a clinician's perspective [PDF]

arXiv, 2022
Prediction uncertainty estimation has clinical significance as it can potentially quantify prediction reliability. Clinicians may trust 'blackbox' models more if robust reliability information is available, which may lead to more models being adopted into clinical practice. There are several deep learning-inspired uncertainty estimation techniques, but
arxiv  

Tuberculous Meningitis in Adults: A Review of 160 Cases [PDF]

, 2012
Objective. This study aimed to evaluate epidemiological, clinical, laboratory, and neuroimaging features of 160 adult patients with tuberculous meningitis (TBM) according to “Thwaites' diagnostic index.” Methods.
Kart Yasar, Kadriye, Pehlivanoglu, Filiz, Sengoz, Gonul   +2 more
core   +3 more sources

CD4+ T cell exhaustion revealed by high PD-1 and LAG-3 expression and the loss of helper T cell function in chronic hepatitis B

BMC Immunology, 2019
Background Immune inhibitory receptors play an important role in chronic infections. However, little is known about their role in hepatitis B virus (HBV) infection.
Yuejiao Dong, Xuefen Li, Lu Zhang, Qiaoyun Zhu, Chunlei Chen, Jiaqi Bao, Yu Chen   +6 more
doaj   +1 more source

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

Revision and Update of the Consensus Definitions of Invasive Fungal Disease From the European Organization for Research and Treatment of Cancer and the Mycoses Study Group Education and Research Consortium. [PDF]

, 2019
BACKGROUND: Invasive fungal diseases (IFDs) remain important causes of morbidity and mortality. The consensus definitions of the Infectious Diseases Group of the European Organization for Research and Treatment of Cancer and the Mycoses Study Group have ...
Akan, H, Alexander, BD, Andes, D, Azoulay, E, Baddley, JW, Bassetti, M, Bialek, R, Bradsher, RW, Bretagne, S, Calandra, T, Caliendo, AM, Castagnola, E, Chen, SC, Clancy, CJ, Cruciani, M, Cuenca-Estrella, M, Decker, CF, Desai, SR, Donnelly, JP, Fisher, B, Groll, AH, Harrison, T, Heussel, CP, Jensen, HE, Kauffman, CA, Kibbler, CC, Kontoyiannis, DP, Kullberg, B-J, Lagrou, K, Lamoth, F, Lehrnbecher, T, Lockhart, SR, Loeffler, J, Lortholary, O, Maertens, J, Marchetti, O, Marr, KA, Masur, H, Meis, JF, Morrisey, CO, Nucci, M, Ostrosky-Zeichner, L, Pagano, L, Pappas, PG, Patterson, TF, Perfect, JR, Prokop, CS, Racil, Z, Roilides, E, Ruhnke, M, Shoham, S, Slavin, MA, Sorrell, TC, Steinbach, WJ, Stevens, DA, Thompson, GR, Vazquez, JA, Verweij, PE, Viscoli, C, Walsh, TJ, Warris, A, Wheat, LJ, White, PL, Wingard, JR, Zaoutis, TE   +64 more
core   +5 more sources

Unlocking the potential of tumor‐derived DNA in urine for cancer detection: methodological challenges and opportunities

Molecular Oncology, EarlyView.
Urine is a rich source of biomarkers for cancer detection. Tumor‐derived material is released into the bloodstream and transported to the urine. Urine can easily be collected from individuals, allowing non‐invasive cancer detection. This review discusses the rationale behind urine‐based cancer detection and its potential for cancer diagnostics ...
Birgit M. M. Wever, Renske D. M. Steenbergen   +1 more
wiley   +1 more source

Prevalence and genetic diversity of human diarrheagenic Escherichia coli isolates by multilocus sequence typing

International Journal of Infectious Diseases, 2018
Background: The population structure of human diarrheagenic Escherichia coli (DEC) isolates derived from worldwide collections remains undefined. Methods: A total of 1196 clinical isolates were obtained from a multilocus sequence typing (MLST) database ...
Fei Yu, Xiao Chen, Shufa Zheng, Dongsheng Han, Yiyin Wang, Ruonan Wang, Baohong Wang, Yu Chen   +7 more
doaj   +1 more source