Results 61 to 70 of about 734,729 (308)
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Diagnostic value of pyruvate kinase isoenzyme type M2 in colon cancer proven with colonoscopy
Advanced Biomedical Research, 2020 Background: Colonoscopy is the gold standard for colon cancer screening; it is also associated with a high cost and complication. Proliferating cells, in particular tumor cells, express a dimeric isoenzyme of pyruvate kinase, termed M2 pyruvate kinase ...
Hamid Kalantari +3 more
doaj +1 more source
Laboratory quality management system: handbook [PDF]
"Achieving, maintaining and improving accuracy, timeliness and reliability are major challenges for health laboratories. Countries worldwide committed themselves to build national capacities for the detection of, and response to, public health events of ...
core
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
National Laboratory System [PDF]
The National Laboratory System was established to ensure a strong system of integrated public health, hospital, and independent laboratories. The goal is to strengthen critical testing and communication for public health issues through systematic ...
core
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Antimicrobial resistance in the practice of primary care physicians: infection diagnosis
Family Medicine & Primary Care ReviewThe selection of appropriate specimens for diagnostic testing constitutes a critical step in the treatment process, as the data thus generated forms the foundation for evidence-based medical decisions.
Hanna Laudy-Wiaderny, Aneta Nitsch-Osuch
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Routine laboratory data for predicting 30-day emergency department revisits: the AXIS-2 risk score
BMC Emergency MedicineBackground Thirty-day emergency department (ED) revisit is a major quality indicator reflecting morbidity and healthcare burden. Laboratory data obtained during outpatient encounters may capture underlying biological stress axes.
Ferhat Demirci, Aylin Demirci
doaj +1 more source
Frontiers in Medicine, 2018 Viscous sputum specimens usually cannot undergo automated extraction, and thus, a pre-homogenization process is desirable before isolating nucleic acids for real-time reverse transcription PCR.
Fei Yu +6 more
doaj +1 more source