Results 31 to 40 of about 2,097,223 (266)

Claudin‐6 Protein Expression in Atypical Teratoid/Rhabdoid Tumors Is Strongly Enriched in the Molecular Subgroup AT/RT‐TYR

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Claudin‐6 has emerged as a promising immunotherapeutic target, yet protein‐level data in atypical teratoid/rhabdoid tumors (AT/RTs) have been inconsistent. We analyzed 36 well‐characterized AT/RT samples and found membranous claudin‐6 protein expression in 58% of cases, with striking enrichment in the molecular subgroup AT/RT‐TYR (100%) and ...
Victoria E. Fincke, Christian Thomas, Michael C. Frühwald, Pascal D. Johann, Martin Hasselblatt   +4 more
wiley   +1 more source

Endotoxin removal by the OXIRIS filter for cardiogenic shock requiring veno-arterial extra-corporeal life support: the ECMORIX randomized controlled trial

Annals of Intensive Care
Background: Most severe cardiogenic shock requires veno-arterial extracorporeal membrane oxygenation (VA-ECMO). The OXIRIS filter, has shown potential in reducing lipopolysaccharide (LPS) levels.
Maxime Nguyen, Marvin Alvarez, Corentin Evezard, Vivien Berthoud, Damien Leleu, Jean-Paul Pais-De-Barros, Olivier Bouchot, Osama Abou-Arab, Belaid Bouhemad, David Masson, Thomas Gautier, Pierre-Grégoire Guinot   +11 more
doaj   +1 more source

BASIC MEDICAL SCIENCES AND PROBLEM-BASED LEARNING: PITFALLS AND POSSIBLE IMPROVEMENT FROM THE PERSPECTIVE OF TEACHERS AND STUDENTS

Jurnal Pendidikan Kedokteran Indonesia, 2020
Background: Basic medical sciences are essential foundation for the constructive learning of clinical sciences. Faculty of Medicine, Universitas Syiah Kuala is currently implementing Problem-based learning (PBL) for basic medical sciences.
Teuku Renaldi, Said Usman, Maimun Syukri, Sofia Sofia, Dedy Syahrizal   +4 more
doaj   +1 more source

Basic medical sciences should be mainly taught by clinicians for a tight integration of basic and clinical sciences in medical education.

Acta Medica Alanya, 2022
Today, medical education faces many problems. However, the most serious problem is the inability to integrate basic and clinical sciences. For this reason, students alienate from basic sciences, and clinicians are leaving sciences to basic scientists ...
Süleyman Oktar
doaj   +1 more source

Time Toxicity in Wilms Tumor: Quantifying the Burden of Healthcare Interaction in the First Year After Diagnosis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Wilms tumor (WT) treatment imposes a significant time burden on patients and their families. Time toxicity is a patient‐centered metric that quantifies the burden of healthcare interaction. We sought to define time toxicity in the first year after diagnosis of WT and hypothesized that it would increase as tumor stage and treatment ...
Caleb Q. Ashbrook, Veerain Gupta, Nicholas J. Clark, Vijay Rings, Lauren E. Corona, Douglass B. Clayton, Daniel J. Benedetti   +6 more
wiley   +1 more source

Transplant-free survival in acute liver failure patients receiving MARS®, plasma exchange or no liver support. A real-life 21-year retrospective cohort study in a referral center

Annals of Intensive Care
Background: Whether Molecular Adsorbent Recirculating System (MARS) dialysis and high-volume plasma exchange (HVPE) may improve survival in acute liver failure (ALF) remains unclear.
Kieran Pinceaux, Félicie Bélicard, Valentin Coirier, Estelle Le Pabic, Pauline Guillot, Flora Delamaire, Benoît Painvin, Quentin Quelven, Mathieu Lesouhaitier, Adel Maamar, Arnaud Gacouin, Pauline Houssel-Debry, Karim Boudjema, Edouard Bardou-Jacquet, Jean-Marc Tadié, Florian Reizine, Christophe Camus   +16 more
doaj   +1 more source

Heterogeneity in the Global Practice of Central Nervous System Staging in Pediatric Acute Lymphoblastic Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Central nervous system (CNS) involvement in childhood acute lymphoblastic leukemia (ALL) is assessed by cell counting and cytomorphology from cerebrospinal fluid (CSF) and is used for treatment stratification worldwide. The ratio of “CNS2” patients in clinical trials ranges from 3% to 40%, with unclear prognostic significance ...
Laura Almási, Bernadett Borbála Huszti, Gábor Barna, Marko Kavcic, Janez Jazbec, Lennart Lenk, Vera Münch, Sophia Polychronopoulou, Ágnes Márk, Maria Thastrup, Lüder H. Meyer, Kjeld Schmiegelow, Cornelia Eckert, Christina Halsey, Dániel J. Erdélyi   +14 more
wiley   +1 more source

Weaning from mechanical ventilation in myasthenic crisis according to WEAN safe: most patients experience intermediate or prolonged weaning with no differences between early and late-onset compared to very-late onset myasthenia Gravis

Annals of Intensive Care
Background: Myasthenic crisis often requires prolonged mechanical ventilation and complex weaning, yet data remain scarce. The objective of this study was to describe the weaning characteristics in patients with myasthenic crisis using the WEAN Safe ...
Clémence Marois, Arthur Combes, Meriem Bouguerra, Alexandra Grinea, Lucas Di Meglio, Thomas Rambaud, Loïc Le Guennec, Francis Bolgert, Benjamin Rohaut, Sophie Demeret, Nicolas Weiss   +10 more
doaj   +1 more source

Emapalumab for Immune Effector Cell‐Associated Hemophagocytic Lymphohistiocytosis‐Like Syndrome Following CD19‐Directed CAR‐T in Two Patients With B‐ALL: Clinical and Biomarker Correlates

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Immune effector cell‐associated hemophagocytic lymphohistiocytosis‐like syndrome (IEC‐HS) is a life‐threatening hyperinflammatory toxicity distinct from cytokine release syndrome (CRS) and neurotoxicity following chimeric antigen receptor T‐cell (CAR‐T) therapy. In a single‐institution retrospective cohort of pediatric and young adult patients
Thomas J. Galletta, Jeremy D. Rubinstein, Christopher E. Dandoy, Ruby Khoury, Angela Faulhaber, Christine L. Phillips, Christa Krupski   +6 more
wiley   +1 more source

Metabolomic stratification of shock: pathophysiological insights for personalized critical care

Annals of Intensive Care
Background: Shock, encompassing septic and cardiogenic etiologies, is a life-threatening condition associated with systemic inflammation, metabolic dysregulation, and high mortality in intensive care units.
Frederic Sangla, Karim Bendjelid, Federico Aletti, Vicente Ribas, Antoine Herpain, Bernardo Bollen Pinto, David Legouis   +6 more
doaj   +1 more source