Results 21 to 30 of about 2,113,439 (265)

Management and monitoring strategies for severe cerebral malaria: a guide for the intensivist

Annals of Intensive Care
Severe malaria, caused by Plasmodium falciparum, poses a critical public health challenge, with cerebral malaria (CM) representing its most severe and life-threatening neurological manifestation. Defined by impaired consciousness (Glasgow Coma Score 
Sonila Vathi, Alberto Corriero, Edith Elianna Rodríguez, Anthony Moreau, Elisa Gouvea Bogossian, Marta Baggiani, Maya Hites, Romain Sonneville, Fabio Silvio Taccone, Michele Salvagno   +9 more
doaj   +1 more source

Exploration of the immunogenetic landscape of hyperprogressive disease after combined immunotherapy in cancer patients

iScience, 2023
Summary: The immune-genetic changes that occur in cancer patients experiencing hyperprogressive disease (HPD) during combined immunotherapy are unclear.
Caifeng Gong, Wen Zhang, Yongkun Sun, Jianzhong Shou, Zhichao Jiang, Tianyi Liu, Shengzhou Wang, Jun Liu, Ying Sun, Aiping Zhou   +9 more
doaj   +1 more source

Central Nervous System Neuroblastoma, FOXR2‐Activated: A Pooled Analysis of Published Clinical Outcomes

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Central nervous system (CNS) neuroblastoma, FOXR2‐activated, is a recently recognized entity in the WHO CNS5 classification, defined by activation of the FOXR2 transcription factor and unique histopathological features. This review synthesizes available literature and pooled clinical data, providing insight into demographics ...
Sudarshawn Damodharan, Mohamed S. Abdelbaki   +1 more
wiley   +1 more source

Hemostatic abnormalities after trauma resuscitation: challenges and strategies in caring for the critically injured patient

Annals of Intensive Care
Severe polytrauma and hemorrhage is a common and life-threatening condition often leading to intensive care unit admission for those who survive their initial injury.
Christopher R. Reed, Nicola Curry, Nicole P. Juffermans, Matthew D. Neal   +3 more
doaj   +1 more source

Investigating the barriers to clinical education among medical students in Iran: A narrative review study

Journal of Family Medicine and Primary Care, 2022
Various factors can affect the clinical education of medical students. The main purpose of this study was to investigate the barriers to clinical educational related to medical students in Iranian universities of medical sciences.
Sahar Vahdat, Nazanin Tanhaei, Somayeh Najafi, Mohammad Hossein Salemi, Fereshteh Karbasian   +4 more
doaj   +1 more source

Feasibility and Safety of Somato‐Cognitive Coordination Therapy for Cerebellar Ataxia Following Pediatric Brain Tumor Treatment

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Cerebellar ataxia after pediatric brain tumor treatment can cause persistent gait, balance, and speech impairment, yet no established rehabilitation strategy exists. Somato‐cognitive coordination therapy (SCCT) is a virtual reality–guided intervention designed to promote sensorimotor integration through visually constrained reaching
Masanobu Takeuchi, Takashi Matsuzawa, Jun Yamanishi, Masahiro Yoshitomi, Junji Ikeda, Shin‐Ichi Tsujimoto, Yasuteru Yamaguchi, Norio Shiba, Dhroov Pathare, Ayumi Kato, Masahiko Hara   +10 more
wiley   +1 more source

The metabolic response to stress in critical illness: updated review on the pathophysiological mechanisms, consequences, and therapeutic implications

Annals of Intensive Care
The understanding of the response to stress in critical illness has significantly improved in recent years. These adaptations unfold across acute, subacute, and chronic phases, with an early adaptive catabolic state, marked anabolic resistance, and a ...
Raphael Mottale, Claire Dupuis, Sylwia Szklarzewska, Jean-Charles Preiser   +3 more
doaj   +1 more source

Prevalence of 21 Physician‐Defined Severe Toxicities Following Childhood Acute Lymphoblastic Leukemia Treatment: Australian Retrospective Cohort Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer, with an overall survival now surpassing 90% in developed countries. However, treatments are not without adverse effects. In this study, we apply the severe toxicity‐free survival (STFS) framework to determine the prevalence of 21 physician‐defined severe ...
Lane Collier, Brittany Grantham, Camilla Grud Nielsen, Louise Lundgren, Liv Andrés‐Jensen, Kjeld Schmiegelow, Chris Selman, Gareth Ball, Elyse Passmore, David A. Elliott, Rachel Conyers   +10 more
wiley   +1 more source

Neuromuscular blockade and their monitoring in the intensive care unit: a multicenter observational prospective study

Annals of Intensive Care
Background: Neuromuscular blocking agents may improve outcomes in specific conditions, including the early phase of acute respiratory distress syndrome.
Bertrand Hermann, Guillaume Decormeille, Tiphanie Gobé, Nathanaël Mangeard, Adel Maamar, Saria Sayadi, Bénédicte Pernod, Nadine Robquin, Jean-Pierre Ponthus, Sophie Le Potier, Pierre Bouju, Angélique Balabanian, Antoine Frouin, Sébastien Moschietto, Gwenaelle Jacq, Emeline Villemont, Clémence Houbé, Anaïs Queyreau, Célina Morand, Florence Boissier, Jean-Baptiste Lascarrou, Sabine Valera, Sami Hraiech, Laure Clouet, Gaël Piton, Cindérella Noël, Anne Joosten, Cécilia Tabra Osorio, Adrien Constan, Jérôme Cecchini, Gwennaelle Mercier, Arnaud Bruyneel, Chloé Villamaux, François Pousset, Nicholas Heming, Laurent Poiroux, Jean-François Llitjos, Saber Davide Barbar   +37 more
doaj   +1 more source

Sustained Therapeutic Efficacy of Intravenous Plasminogen Concentrate in Pediatric Patients With Type 1 Plasminogen Deficiency: An Analysis of Dosing Parameters and Clinical Outcomes

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Type 1 plasminogen deficiency (PLGD‐1) is an ultra‐rare autosomal recessive disorder caused by variants in the PLG gene and affects approximately 1.6 individuals per million. The condition is characterized by decreased plasminogen levels and impaired function, resulting in fibrin‐rich lesions on mucous membranes throughout the body.
Charles Nakar, Karen Thibaudeau, Mary Mathias, Heather McDaniel, Madlen Reschke, Klaus Tenbrock, Joseph M. Parker, Amy Shapiro   +7 more
wiley   +1 more source