Results 241 to 250 of about 17,262,511 (380)

The association between level of trauma care and clinical outcome measures: A systematic review and meta-analysis

, 2020
J.C. vanDitshuizen, C.R.L. van deDriessche, Charlie Sewalt, E.M.M. vanLieshout, M.H.J. Verhofstad, D. deHartog   +5 more
openalex   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Clinical outcome and proportion of hereditary cancer genes gPV in TNBC: the HEaRTBeat study. [PDF]

NPJ Breast Cancer
Rotolo M, Piombino C, Venturelli M, Tenedini E, Toss A, Barbieri E, Gasparini E, Marchi I, Domati F, Civallero M, Marcheselli L, Razzaboni E, Tagliafico E, Dominici M, Cortesi L.   +14 more
europepmc   +1 more source

Evaluating the Economic and Clinical Impacts of Pharmaceutical Supply Chain Centralization through AI-Driven Predictive Analytics: Comparative Lessons from Large-Scale Centralized Procurement Systems and Implications for Drug Pricing, Availability, and Cardiovascular Health Outcomes in the U.S.

Okolue Chukwudi Anthony, Emmanuel Oluwagbade, Adeola Bakare, Blessing Oluwadamisi Animasahun   +3 more
openalex   +1 more source

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Changes in the microbiota following allogeneic hematopoietic stem cell transplantation: A potential bioguide for clinical outcome? [PDF]

Hematol Transfus Cell Ther
Gurer-Kluge EE, Oguz FS, Aktas Z, Besisik SK, Sezerman U, Oncul O, Gulbas Z.   +6 more
europepmc   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

TLX1 translocation variants and enhancer hijacking influence clinical outcome in T-cell acute lymphoblastic leukemia. [PDF]

Hemasphere
Balducci E, Steimlé T, Cieslak A, Charbonnier G, Pinton A, Simonin M, Smith C, Louis V, Féroul M, Delafoy M, Kaltenbach S, Bidet A, Grange B, Rigollet L, Villarese P, Touzart A, Dombret H, Baruchel A, Boissel N, Asnafi V.   +19 more
europepmc   +1 more source

Beyond clinical outcomes

Hepatitis C virus (HCV) infections in people who inject drugs (PWID) can now be treated and cured. However, the impact that HCV treatment has on drug-user health, practices and wellbeing is not known. The aim of this research was to understand the non-clinical impact that HCV treatment has in PWID and their reasons for accessing and completing ...
Torrens, Marta||, Soyemi, Tokunbo, Bowman, Darcy, Schatz, Eberhard   +3 more
openaire   +1 more source