Results 101 to 110 of about 1,543,622 (248)
CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane +12 morewiley +1 more sourceValidation of a health economics evaluation framework for minimally invasive congenital heart disease clinical pathways: A multi-center disparity analysis
Vascular Investigation and TherapyBACKGROUND:
Significant regional disparities exist in implementing minimally invasive congenital heart disease (CHD) clinical pathways across China, leading to inefficient resource utilization and increased healthcare costs.Xiang Li, Chao Xue, Kai Ren, Hanzhao Zhu, Liyun Zhang, Bin Zhang, Chen Yang, Dongxu Wang, Mengen Zhai, Yi Si, Jian Zuo, Xuezeng Xu, Wei Yi, Zhenxiao Jin, Jian Yang, Jincheng Liu, Shiqiang Yu, Weixun Duan +17 moredoaj +1 more sourceUrological cancer care pathways: development and use in the context of systematic reviews and clinical practice guidelines [PDF]
, 2011 Sara MacLennan, Steven MacLennan, Mari Imamura, Muhammad Imran Omar, Luke Vale, Thomas Lam, Pamela Royle, Justine Royle, Satchi Swami, Rob Pickard, Samuel McClinton, T.R. Leyshon Griffiths, Philipp Dahm, James N’Dow, James N’Dow +14 moreopenalex +1 more sourceSupplementary Figure 1 from PI3K–mTOR Pathway Inhibition Exhibits Efficacy Against High-grade Glioma in Clinically Relevant Mouse Models
, 2023 Fan Lin, Mark C. de Gooijer, Diana Hanekamp, G. Chandrasekaran, Levi C.M. Buil, Nishita Thota, Rolf W. Sparidans, Jos H. Beijnen, Tom Würdinger, Olaf van Tellingen +9 moreopenalex +1 more sourceReduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity
Molecular Oncology, EarlyView.A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh +8 morewiley +1 more sourceTable S2 from Phase II Clinical Trial of Everolimus in a Pan-Cancer Cohort of Patients with mTOR Pathway Alterations
, 2023 Elio Adib, Katarzyna Klonowska, Κρινιώ Γιαννίκου, T. Khanh, Solida Pruitt-Thompson, Ketki Bhushan, Matthew I. Milstein, Jennifer Hedglin, Katherine E. Kargus, Lynette M. Sholl, Junko Tsuji, David M. Hyman, Anne Sisk, Geoffrey I. Shapiro, Hebert Alberto Vargas, James J. Harding, Martin H. Voss, Gopa Iyer, David J. Kwiatkowski +18 moreopenalex +1 more source
