Results 61 to 70 of about 2,614,061 (283)

NF2/merlin in hereditary neurofibromatosis 2 versus cancer: biologic mechanisms and clinical associations. [PDF]

, 2013
Inactivating germline mutations in the tumor suppressor gene NF2 cause the hereditary syndrome neurofibromatosis 2, which is characterized by the development of neoplasms of the nervous system, most notably bilateral vestibular schwannoma.
Angelo, Laura S, Kurzrock, Razelle, Schroeder, Rebecca Dunbar   +2 more
core   +3 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

The role of a community health worker-delivered preconception and pregnancy intervention in achieving a more positive pregnancy experience: the Bukhali trial in Soweto, South Africa

BMC Women's Health
Background A patient-centered, human-rights based approach to maternal care moves past merely reducing maternal mortality and morbidity, towards achieving a positive pregnancy experience.
Larske M. Soepnel, Khuthala Mabetha, Shane A. Norris, Molebogeng Motlhatlhedi, Nokuthula Nkosi, Sonja Klingberg, Stephen Lye, Catherine E. Draper   +7 more
doaj   +1 more source

Evaluating the Global Intensive Feeding Therapy (GIFT) for Children with CHARGE Syndrome: A Quasi-Experimental Study

Children
Background: This pilot investigation aimed to evaluate the efficacy of Global Intensive Feeding Therapy (GIFT) on feeding and swallowing abilities in children with CHARGE Syndrome (CS).
Antonella Cerchiari, Francesca Pizza, Giorgia Biondo, Carolina Giordani, Martina De Paolis, Gessica Della Bella, Massimiliano Raponi, Marco Tofani   +7 more
doaj   +1 more source

Effectiveness and Sustainability of an Antimicrobial Stewardship Program for Perioperative Prophylaxis in Pediatric Surgery

Pathogens, 2020
Background—Appropriate perioperative antibiotic prophylaxis (PAP) is essential to prevent surgical site infections (SSIs) and to avoid antibiotics misuse.
Daniele Donà, Dora Luise, Elisa Barbieri, Nicola Masiero, Sonia Maita, Luca Antoniello, Theoklis Zaoutis, Carlo Giaquinto, Piergiorgio Gamba   +8 more
doaj   +1 more source

Pathways to clinical CLARITY: volumetric analysis of irregular, soft, and heterogeneous tissues in development and disease [PDF]

, 2017
Three-dimensional tissue-structural relationships are not well captured by typical thin-section histology, posing challenges for the study of tissue physiology and pathology. Moreover, while recent progress has been made with intact methods for clearing,
Arda, H. Efsun, Burns, Vanessa M, Chakravarthy, Harini, Charville, Gregory, Deisseroth, Karl, Efimov, Igor R, Engberg, Kristin, Gu, Xueying, Holzem, Katherine, Hsueh, Brian, Kim, Seung, Pauerstein, Philip, Vogel, Hannes, Wang, Ai-Chi, Ye, Li   +14 more
core   +2 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Pharmacogenetics of analgesic drugs [PDF]

, 2013
• Individual variability in pain perception and differences in the efficacy of analgesic drugs are complex phenomena and are partly genetically predetermined.
Branford, R, Cregg, R, Gubbay, A, Russo, G, Sato, H   +4 more
core   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

The Business Process Model and Notation Used for the Representation of Alzheimer’s Disease Patients Care Process

Data, 2020
Currently, the number of patients with neurological diseases is increasing, especially those older than 65 suffering from Alzheimer’s disease. This development increases the emphasis on understanding and mapping treatment and care processes, not ...
Martin Kopecky, Hana Tomaskova
doaj   +1 more source