Results 61 to 70 of about 1,543,622 (248)

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

The Effect of Coordinating the Outpatient Treatment across Medical Specialities for Patients With Multimorbidity

International Journal of Integrated Care
Introduction: Patients with multimorbidity attend multiple outpatient clinics. We assessed the effects on hospital use of scheduling several outpatient appointments to same-day visits in a multidisciplinary outpatient pathway (MOP).
Cathrine Bell, Charlotte Weiling Appel, Anders Prior, Anne Frølich, Asger Roer Pedersen, Peter Vedsted   +5 more
doaj   +1 more source

Pharmacists as Interprofessional Collaborators and Leaders through Clinical Pathways

Pharmacy, 2018
Pharmacists possess pivotal competencies and expertise in developing clinical pathways (CPs). We present a tertiary care facility experience of pharmacists vis-a-vis interprofessional collaboration for designing and implementing CPs.
Sherine Ismail, Mohamed Osman, Rayf Abulezz, Hani Alhamdan, K. H. Mujtaba Quadri   +4 more
doaj   +1 more source

Degenerative findings in lumbar spine MRI: an inter-rater reliability study involving three raters

Chiropractic & Manual Therapies, 2020
Background For diagnostic procedures to be clinically useful, they must be reliable. The interpretation of lumbar spine MRI scans is subject to variability and there is a lack of studies where reliability of multiple degenerative pathologies are rated ...
Klaus Doktor, Tue Secher Jensen, Henrik Wulff Christensen, Ulrich Fredberg, Morten Kindt, Eleanor Boyle, Jan Hartvigsen   +6 more
doaj   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Child Amputee Prosthetics Project—Prosthesis Satisfaction Inventory (CAPP-PSI): Validation of Italian Version in Children with Upper Limb Amputation

Children
Background: The Child Amputee Prosthetics Project—Prosthesis Satisfaction Inventory (CAPP-PSI) is a comprehensive instrument designed to measure satisfaction across functionality, aesthetic, and service domains.
Luigino Santecchia, Gessica Della Bella, Francesca Caspi, Paola Luttazi, Lorenzo Pochiero, Fabrizio Taffoni, Giordana Mariani, Marco Gaudenzi, Donatella Valente, Marco Tofani   +9 more
doaj   +1 more source

Retracted: Effect Analysis of Clinical Pathway Nursing Combined with Humanized Nursing in Cerebral Infarction [PDF]

, 2023
Computational Intelligence and Neuroscience
openalex   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

Exodontic surgery in patients with coagulation disorders: a literature review

Annali di Stomatologia
BACKGROUND: Nowadays, patients with coagulation disorders, whether inherited or acquired, have grown significantly. Anticoagulant drugs (vitamin K antagonists, VKA, and the new oral anticoagulants, NAO) and Antiplatelet drugs are a powerful means for ...
Mirko Martelli, Pasquale Giallaurito, Alessandro D’Aurelio, Francesco Gianfreda, Marco Gargari, Patrizio Bollero, Alberta Barlattani, Liliana Ottria   +7 more
doaj   +1 more source