Results 71 to 80 of about 2,614,061 (283)

Nitro-fatty acid formation and metabolism [PDF]

, 2018
Nitro-fatty acids (NO 2 -FA) are pleiotropic modulators of redox signaling pathways. Their effects on inflammatory signaling have been studied in great detail in cell, animal and clinical models primarily using exogenously administered nitro-oleic acid ...
Bonacci, Gustavo Roberto, Buchan, Gregory J., Fazzari, Marco, Gelhaus Wendell, Stacy, Salvatore, Sonia Rosana   +4 more
core   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Examining maternal health literacy as a mediator of the relationship between social vulnerability and caregiving practices for improving infant development

BMC Public Health
This study examined whether specific dimensions of maternal health literacy mediated the relationship between social vulnerability and maternal caregiving confidence, specifically breastfeeding self-efficacy and maternal beliefs about play, among 168 ...
Lauren Stuart, Claire Hart, Rachana Desai, Shane A. Norris, Fiona Bennin, Helene Theunissen, Alessandra Prioreschi   +6 more
doaj   +1 more source

Virtual patients design and its effect on clinical reasoning and student experience : a protocol for a randomised factorial multi-centre study [PDF]

, 2012
Background Virtual Patients (VPs) are web-based representations of realistic clinical cases. They are proposed as being an optimal method for teaching clinical reasoning skills. International standards exist which define precisely what constitutes a VP.
A Adebajo, AA Montgomery, AP Round, AS Wilson, CP Friedman, D Moher, DA Cook, DA Cook, DA Cook, David Davies, F Ruderich, G Bordage, G Bordage, G Huang, G Page, GR Norman, J Bateman, J Bateman, J Wilbanks, James Bateman, Jane Kidd, JB McGee, LJ Badcock, M Begg, M Botezatu, Maggie E Allen, MM Triola, MR Fischer, N Berman, N Zary, N Zary, Nick Parsons, P Sedlmeier, R Ellaway, RH Ellaway, RH Ellaway, S Huwendiek, T Wolpaw   +37 more
core   +2 more sources

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Gut Microbial Signatures Associated with Cryptosporidiosis: A Case Series

Microorganisms
Cryptosporidium spp. are zoonotic protozoan parasites with a global prevalence, with both gastrointestinal and pulmonary involvement. Though symptoms can often be relatively mild, they can become severe and even fatal in children under five, the elderly,
Antonia Piazzesi, Stefania Pane, Lorenza Romani, Francesca Toto, Matteo Scanu, Riccardo Marsiglia, Federica Del Chierico, Nicola Cotugno, Paolo Palma, Lorenza Putignani   +9 more
doaj   +1 more source

Clinical Pathways to Disability [PDF]

This paper examines the pathways by which individuals transition from healthy to disabled. Because of the high prevalence and costs associated with disability, understanding these pathways is critical to developing interventions to prevent or minimize ...
David M. Cutler, Kate A. Stewart, Mary Beth Landrum   +2 more
core  

Rhabdomyosarcoma: Advances in Molecular and Cellular Biology. [PDF]

, 2015
Rhabdomyosarcoma (RMS) is the most common soft tissue malignancy in childhood and adolescence. The two major histological subtypes of RMS are alveolar RMS, driven by the fusion protein PAX3-FKHR or PAX7-FKHR, and embryonic RMS, which is usually ...
Duan, Zhenfeng, Guo, Wei, Hornicek, Francis J, Mankin, Henry J, Shen, Jacson K, Sun, Xin   +5 more
core   +3 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Risk and Protective Factors for Executive Function in Vulnerable South African Preschool-Age Children

Journal of Cognition
Executive function (EF) theory and research continues to under-represent the contexts in which the majority of the world’s children reside, despite their potential to support, refute, or refine our current understandings.
Caylee J. Cook, Steven J. Howard, Hleliwe Makaula, Rebecca Merkley, Mbulelo Mshudulu, Nosibusiso Tshetu, Gaia Scerif, Catherine E. Draper   +7 more
doaj   +1 more source