A systematic literature review on the efficacy-effectiveness gap: comparison of randomized controlled trials and observational studies of glucose-lowering drugs [PDF]
Aim: To identify a potential efficacy–effectiveness gap and possible explanations (drivers of effectiveness) for differences between results of randomized controlled trials (RCTs) and observational studies investigating glucose-lowering drugs ...
Ankarfeldt, Mikkel Z+6 more
core +3 more sources
Background: Medication communication from physicians to patients often is poor, by this among others enhancing the risk of non-adherence. In this context, a neglect regarding the prescription talk has been complained.Aim of the project: In a newly ...
Hauser, Katarina+5 more
doaj +1 more source
Clinical pharmacology of cefazolin
Cefazolin is a first-generation cephalosporin that is active against gram-positive bacteria and has modest activity against gram-negative organisms, and cefazolin is excreted by glomerular filtration.
Gian Maria Pacifici
doaj +1 more source
Mechanisms in neurodegenerative disorders and role of non-pharmacological interventions in improving neurodegeneration and its clinical correlates: A review [PDF]
Mild cognitive impairment (MCI) leading to dementia results in a constellation of psychiatric disorders including depression, mood disorders, schizophrenia and others. With increasing age, mild cognitive impairment leads to increased disability-adjusted life-years and healthcare burden.
arxiv
The implementation of HTA in medicine pricing and reimbursement policies in Indonesia:Insights from multiple stakeholders [PDF]
OBJECTIVES: This study aimed to identify the barriers and facilitators to improve the use of health technology assessment (HTA) for the selection of medicines listed in the e-Catalogue and the national formulary in Indonesia.
Afd Pharmacoepi & Clinical Pharmacology+8 more
core +2 more sources
The CNS Neuroscience & Therapeutics provides a medium for rapid publication of original clinical, experimental, and translational research papers, timely reviews, and reports of novel findings of therapeutic relevance to the central nervous system.
Boltze, Johannes+8 more
core +1 more source
Relevance. Among the professional competencies, a graduate of a medical faculty should not only determine drugs for the treatment of typical diseases, but also be able to correct errors in prescribing; warn, identify and report adverse drug reactions ...
M.V. Khaitovych+5 more
doaj +1 more source
From multiscale biophysics to digital twins of tissues and organs: future opportunities for in silico pharmacology [PDF]
With many advancements in in silico biology in recent years, the paramount challenge is to translate the accumulated knowledge into exciting industry partnerships and clinical applications. Achieving models that characterize the link of molecular interactions to the activity and structure of a whole organ are termed multiscale biophysics. Historically,
arxiv
Pharmacology and clinical drug candidates in redox medicine [PDF]
SIGNIFICANCE Oxidative stress is suggested to be a disease mechanism common to a wide range of disorders affecting human health. However, so far, the pharmacotherapeutic exploitation of this, for example, based on chemical scavenging of pro-oxidant ...
Casas, Ana I+11 more
core +2 more sources
Integrating Expert ODEs into Neural ODEs: Pharmacology and Disease Progression [PDF]
Modeling a system's temporal behaviour in reaction to external stimuli is a fundamental problem in many areas. Pure Machine Learning (ML) approaches often fail in the small sample regime and cannot provide actionable insights beyond predictions. A promising modification has been to incorporate expert domain knowledge into ML models.
arxiv