Results 31 to 40 of about 9,870,305 (401)

Will Artificial Intelligence for Drug Discovery Impact Clinical Pharmacology?

Clinical pharmacology and therapy, 2020
As the field of artificial intelligence and machine learning (AI/ML) for drug discovery is rapidly advancing, we address the question “What is the impact of recent AI/ML trends in the area of Clinical Pharmacology?” We address difficulties and AI/ML ...
A. Zhavoronkov, Q. Vanhaelen, Tudor I. Oprea   +2 more
semanticscholar   +1 more source

Neonatal pharmacology and clinical implications

Drugs in Context, 2019
During the neonatal period, there is physiological immaturity of organs, systems and metabolic pathways that influences the pharmacokinetics and pharmacodynamics of administered drugs, the dosage of which should be constantly amended, considering the ...
Antonio Ruggiero, Anna Ariano, Silvia Triarico , Michele Antonio Capozza, Pietro Ferrara, Giorgio Attinà   +5 more
doaj   +1 more source

Targeting inflammation to reduce cardiovascular disease risk [PDF]

, 2017
This joint themed section of the British Journal of Pharmacology and the British Journal of Clinical Pharmacology stems from a joint British Pharmacological Society – Italian Society of Pharmacology symposium held at the 37th National Congress of the ...
Cirino, Guiseppe, Maffia, Pasquale
core   +1 more source

Haplotypes of the WNK1 gene associate with blood pressure variation in a severely hypertensive population from the British Genetics of Hypertension study.

Human Molecular Genetics, 2005
Mutations in the WNK1 gene cause Gordon's syndrome, a rare Mendelian form of hypertension. We assessed whether common WNK1 variants might also contribute to essential hypertension (EH), a multifactorial disorder affecting > 25% of the adult population ...
S. Newhouse, C. Wallace, R. Dobson, C. Mein, J. Pembroke, M. Farrall, D. Clayton, Morris J. Brown, N. Samani, A. Dominiczak, J. Connell, J. Webster, G. Lathrop, M. Caulfield, P. Munroe, P. Munroe, Clinical Pharmacology, William Harvey   +17 more
semanticscholar   +1 more source

Clinical Pharmacology & Therapeutics: Past, Present, and Future. [PDF]

, 2017
Clinical Pharmacology & Therapeutics (CPT), the definitive and timely source for advances in human therapeutics, transcends the drug discovery, development, regulation, and utilization continuum to catalyze, evolve, and disseminate discipline ...
Terzic, Andre, Waldman, Scott A.
core   +2 more sources

Toward a clinical practice guide in pharmacogenomics testing for functional polymorphisms of drug-metabolizing enzymes. Gene/drug pairs and barriers perceived in Spain [PDF]

, 2012
The development of clinica lpractice recommendations or guidelines for the clinical use of biomarkers is an issue of great importance withr regard to adverse drug reactions.The poten-tial of pharmacogenomicbiomarkers has been extensively investigated in
Abad Santos, Francisco, Aldea, Ana, Alonso-Navarro, Hortensia, Bernal, María Luisa, Borobia, Alberto M., Borràs, Emma, Carballo, Miguel, Carvajal, Alfonso, García-Agúndez, José Augusto, García-Martín, Elena, García-Muñiz, José D., Gervasini, Guillermo, Jiménez-Jiménez, Félix Javier, Lucena, María Isabel, Martínez, Carmen, Sacristán, José A., Salado, Inés, Sinués, Blanca, Vicente, Jorge   +18 more
core   +4 more sources

Effectiveness of Revised Pharmacology Record Books as a Teaching-Learning Method for Second Year Medical Students [PDF]

Journal of Clinical and Diagnostic Research, 2016
Introduction: The goal of teaching medical undergraduates Pharmacology is to form a sound foundation of therapeutics. The pharmacology record books are maintained as a part of the curriculum.
Dhanya Sasidharan Palappallil, Reneega Gangadhar   +1 more
doaj   +1 more source

Prescriptive Appropriateness: Inhospital Adherence to Proton Pump Inhibitors Deprescription Flow Chart

Pharmaceuticals, 2023
The prescriptive appropriateness of Proton Pump Inhibitors (PPIs) in polypharmacy is controversial. PPIs are often overprescribed and the risk of prescribing errors and adverse drug reactions increases for each additional drug added to therapy.
Giammarco Baiardi, Giulia Calvini, Serena Panarello, Chiara Fioravanti, Manuela Stella, Antonietta Martelli, Giancarlo Antonucci, Francesca Mattioli   +7 more
doaj   +1 more source

Clinical Pharmacology and Interplay of Immune Checkpoint Agents: A Yin-Yang Balance.

Annual Review of Pharmacology and Toxicology, 2020
T cells have a central role in immune system balance. When activated, they may lead to autoimmune diseases. When too anergic, they contribute to infection spread and cancer proliferation.
A. Géraud, P. Gougis, A. Vozy, C. Anquetil, Y. Allenbach, E. Romano, E. Funck-Brentano, J. Moslehi, Douglas B. Johnson, J. Salem   +9 more
semanticscholar   +1 more source

Advancing pharmacometrics and systems pharmacology. [PDF]

, 2012
Pharmacometrics and systems pharmacology are emerging as principal quantitative sciences within drug development and experimental therapeutics. In recognition of the importance of pharmacometrics and systems pharmacology to the discipline of clinical ...
Terzic, Andre, Waldman, Scott A.
core   +2 more sources