Results 81 to 90 of about 10,685,508 (300)
, 2012 Aim:The purpose of the present study is to assess clinical reasoning skills of students at Anka-ra University School of Medicine. The study was conducted in the 2006–2007 academic year, including 156 Year 3 (64%) students and 98 Year 5 (72%) students ...
Özden Palaoğlu, Meral Demirören
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Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Applying Artificial Intelligence to Clinical Guidelines: The GLARE Approach.
, 2003 In this paper, we present GLARE, a domain-independent system for acquiring, representing and executing clinical guidelines. GLARE is characterized by the adoption of Artificial Intelligence (AI) techniques at different levels in the definition and ...
Gianluca Correndo +17 more
core +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Molecular Oncology, EarlyView.Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens +6 more
wiley +1 more source
Clinical Reasoning at a Distance
, 2012 Introduction / Background:Strong communication skills surrounding the clinical reasoning process have been shown to be an essential component in the development of the clinicians’ reasoning skills.
Newsham-West, Richard John
core
Clinical Reasoning Assessment Methods: A Scoping Review and Practical Guidance.
Academic medicine : journal of the Association of American Medical Colleges, 2019 PURPOSE An evidence-based approach to assessment is critical for ensuring the development of clinical reasoning (CR) competence. The wide array of CR assessment methods creates challenges for selecting assessments fit for the purpose; thus, a synthesis ...
M. Daniel +16 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski +12 more
wiley +1 more source
Clinical reasoning difficulties: A taxonomy for clinical teachers
Medical Teacher, 2012 Clinical reasoning is the cornerstone of medical practice. To date, there is no established framework regarding clinical reasoning difficulties, how to identify them, and how to remediate them.To identify the most common clinical reasoning difficulties as they present in residents' patient encounters, case summaries, or medical notes.
Audetat Voirol, Marie-Claude +6 more
openaire +3 more sources
PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines
FEBS Open Bio, EarlyView.Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart +7 more
wiley +1 more source