Results 81 to 90 of about 5,880,836 (301)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Assessment of Medical Student’s Clinical Reasoning Skills in the Problem Based Learning-Integrated Curriculum

, 2012
Aim:The purpose of the present study is to assess clinical reasoning skills of students at Anka-ra University School of Medicine. The study was conducted in the 2006–2007 academic year, including 156 Year 3 (64%) students and 98 Year 5 (72%) students ...
Özden Palaoğlu, Meral Demirören
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

User-centered visual analysis using a hybrid reasoning architecture for intensive care units [PDF]

, 2012
One problem pertaining to Intensive Care Unit information systems is that, in some cases, a very dense display of data can result. To ensure the overview and readability of the increasing volumes of data, some special features are required (e.g., data ...
Mehdaoui, Hossein, Zennir, Youcef, Hubert, Hervé, Kamsu-Foguem, Bernard, Lemdani, Mohamed, Tchuenté Foguem, Germaine, Allart, Laurent, Vilhelm, Christian, Zitouni, Djamel, Ravaux, Pierre   +9 more
core   +1 more source

Models of clinical reasoning with a focus on general practice: a critical review

Journal of Advances in Medical Education and Professionalism, 2017
Introduction: Diagnosis lies at the heart of general practice. Every day general practitioners (GPs) visit patients with a wide variety of complaints and concerns, with often minor but sometimes serious symptoms.
SHAHRAM YAZDANI, MOHAMMAD HOSSEINZADEH, FAKHROLSADAT HOSSEINI   +2 more
doaj  

Conceptualizations of anaesthetists’ clinical reasoning expertise: protocol for a systematic review and qualitative thematic synthesis

Systematic Reviews
Background Expertise involves a high level of knowledge or skill in a specific area. Medical expertise encompasses knowledge, technical skills, and socio-cognitive skills like clinical reasoning, essential for accurate diagnosis and treatment.
Jean-Noël Evain, Mathilde Giffard, Julien Picard, Issam Tanoubi, Sébastien Pili Floury, Guillaume Besch, David Ferreira   +6 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Reasoning, models, and images: behavioral measures and cortical activity [PDF]

, 2003
The goal of this study was to investigate the neurocognitive processes of mental imagery in deductive reasoning. Behavioral studies yielded four sorts of verbal relations: (1) visuospatial relations that are easy to envisage both visually and spatially; (
Johnson Laird, PN, Knauff, Markus, Fangmeier, Thomas, Johnson-Laird, P., Knauff, M., Ruff, C., Fangmeier , T., Ruff, Christian C., Fangmeier, T, Ruff, CC, Knauff, M, Johnson-Laird, Philip N.   +11 more
core   +1 more source

Clinical reasoning difficulties: A taxonomy for clinical teachers

Medical Teacher, 2012
Clinical reasoning is the cornerstone of medical practice. To date, there is no established framework regarding clinical reasoning difficulties, how to identify them, and how to remediate them.To identify the most common clinical reasoning difficulties as they present in residents' patient encounters, case summaries, or medical notes.
Audetat Voirol, Marie-Claude, Laurin, Suzanne, Sanche, Gilbert, Béïque, Caroline, Fon, Nathalie Caire, Blais, Jean-Guy, Charlin, Bernard   +6 more
openaire   +3 more sources